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ENTRY EC 6.2.1.25 Enzyme
NAME benzoate---CoA ligase;
benzoate---coenzyme A ligase;
benzoyl-coenzyme A synthetase;
benzoyl CoA synthetase (AMP forming)
CLASS Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
SYSNAME benzoate:CoA ligase (AMP-forming)
REACTION ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA [RN:R01422]
ALL_REAC R01422
SUBSTRATE ATP [CPD:C00002];
benzoate [CPD:C00180];
CoA [CPD:C00010]
PRODUCT AMP [CPD:C00020];
diphosphate [CPD:C00013];
benzoyl-CoA [CPD:C00512]
COMMENT Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates.
HISTORY EC 6.2.1.25 created 1989
REFERENCE 1
AUTHORS Hutber, G.N. and Ribbons, D.W.
TITLE Involvement of coenzyme-A esters in the metabolism of benzoate and cyclohexanecarboxylate by Rhodopseudomonas palustris.
JOURNAL J. Gen. Microbiol. 129 (1983) 2413-2420.
REFERENCE 2 [PMID:2857161]
AUTHORS Schennen U, Braun K, Knackmuss HJ.
TITLE Anaerobic degradation of 2-fluorobenzoate by benzoate-degrading, denitrifying bacteria.
JOURNAL J. Bacteriol. 161 (1985) 321-5.
PATHWAY ec00362 Benzoate degradation
ec00627 Aminobenzoate degradation
ec01100 Metabolic pathways
ec01120 Microbial metabolism in diverse environments
ORTHOLOGY K04105 4-hydroxybenzoate-CoA ligase
K04110 benzoate-CoA ligase
GENES RPJ: N234_07060
REU: Reut_A1327
REH: H16_A1412(h16_A1412) H16_B1918(h16_B1918)
CNC: CNE_1c14400(bclA)
RME: Rmet_1224(bzdA)
CTI: RALTA_A1325 RALTA_B1617
CBW: RR42_m1521
BGL: bglu_2g11460
BUG: BC1001_2395
BGE: BC1002_1980
BGF: BC1003_1063
BXE: Bxe_A1419 Bxe_C0896
BPH: Bphy_1543
BRH: RBRH_00494
BPY: Bphyt_2700
BPT: Bpet3574
AXY: AXYL_05035
RFR: Rfer_0216
POL: Bpro_1624 Bpro_2983
PNA: Pnap_2948
VEI: Veis_0730
DAC: Daci_0076
DEL: DelCs14_0077
VAP: Vapar_0089
VPE: Varpa_0102
CTT: CtCNB1_0097
RTA: Rta_22340
LCH: Lcho_3655
EBA: ebA2757(bclA) ebA5301(bclA)
AZO: azo3052(bzdA)
AZA: AZKH_4514(bclA)
AZI: AzCIB_4632
TMZ: Tmz1t_3136
SHD: SUTH_01659
GME: Gmet_2143(bamY)
GLO: Glov_2397
GEO: Geob_0200(bamY)
GEM: GM21_2825
DMA: DMR_19390
DPR: Despr_3172
SAT: SYN_02896 SYN_02898
BJA: blr1077
BJU: BJ6T_11070
BJP: RN69_05405
BRA: BRADO6791
BBT: BBta_0747 BBta_6637(badA)
BRS: S23_67390
AOL: S58_06690
BRC: BCCGELA001_34230
RPA: RPA0661(badA) RPA0669(hbaA)
RPB: RPB_4656
RPC: RPC_1016 RPC_1025
RPD: RPD_0878 RPD_1526 RPD_1534
RPE: RPE_0592 RPE_0604
RPT: Rpal_0728 Rpal_0736
RPX: Rpdx1_4117
RVA: Rvan_0044
RHZ: RHPLAN_60910
SIL: SPO3697(badA-1)
JAN: Jann_0669
SWI: Swit_0829
MAG: amb2869
MAGX: XM1_2792(bclA)
GYC: GYMC61_2828
SCB: SCAB_8391
AMD: AMED_8609(badA)
PDX: Psed_1491
DBLINKS ExplorEnz - The Enzyme Database: 6.2.1.25
IUBMB Enzyme Nomenclature: 6.2.1.25
ExPASy - ENZYME nomenclature database: 6.2.1.25
UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.25
BRENDA, the Enzyme Database: 6.2.1.25
CAS: 95329-17-2
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