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Preliminary title update

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sidneymbell
sidneymbell committed Jul 10, 2019
1 parent dde1ff4 commit 5afa812fcdc356961911af432025c17fcd6a3422
Showing with 2 additions and 2 deletions.
  1. +2 −2 manuscript/dengue-antigenic-dynamics.tex
@@ -19,7 +19,7 @@
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\title{Dengue antigenic relationships predict evolutionary dynamics}
\title{Dengue genetic divergence generates within-serotype antigenic variation, but serotypes dominate evolutionary dynamics}

\author[1,2*]{Sidney Bell}
\author[3,4]{Leah Katzelnick}
@@ -521,7 +521,7 @@ \subsection*{Viral clade dynamics}
This hypothesis is consistent with the findings of \citet{nagao2008decreases}, who demonstrated that dengue epidemiological dynamics are compatible with a model wherein immunity confers protection against severe symptoms, but not asymptomatic infection.
This is also consistent with \citet{tenBosch2018contributions}'s findings that asymptomatic dengue infections contribute to onward transmission.

Alternatively, this lack of signal could be methodlogically explained if either (A) genotype-level frequency trajectories estimated from public data are overly noisy for this application or (B) our model of antigenic fitness based on PRNT assay data does not match reality, due to either PRNT assay data not well reflecting human immunity or due to our particular model formulation that parameterizes immunity from titer distances (Eq.~\ref{eq_population_immunity}--\ref{eq_fitness}).
Alternatively, this lack of signal could be methodologically explained if either (A) genotype-level frequency trajectories estimated from public data are overly noisy for this application or (B) our model of antigenic fitness based on PRNT assay data does not match reality, due to either PRNT assay data not well reflecting human immunity or due to our particular model formulation that parameterizes immunity from titer distances (Eq.~\ref{eq_population_immunity}--\ref{eq_fitness}).
In the present analysis, we are not able to firmly resolve these disparate possibilities.

These observations are also subject to caveats imposed by the available data and model assumptions.

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