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|##Extensive divergence makes sitewise measures of genetic linkage ineffective|
|For pairs of biallelic sites (ignoring rare variants), R^2 was used to estimate how strongly the allele in one site predicts the allele in the second site, with values of 0 indicating no linkage and 1 indicating perfect linkage. The mean value of R^2 was 0.044, indicating very low levels of linkage overall.|
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|## Figure S2: No evidence of linkage between nonadjacent segments of the SIV genome.|
|The alignment used for GARD analyses (LANL compendium with HIV overrepresentation reduced) was split along the breakpoints identified by GARD to yield the 12 genomic segments, and a maximum likelihood tree was constructed for each. The number of steps required to turn one tree topology into another was assessed for each pair of trees with the Rooted Subtree-Prune-and-Regraft (rSPR) package. Segment pairs with similar topologies have lower scores than segments with less similar topologies.|