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QuadMutex: Quadratic Driver Mutation Explorer Version: 1.0 Date: 3/1/2017 Authors: Yahya Bokhari & Tom Arodz contact: bokhariya@vcu.edu tarodz@vcu.edu --------------------------------------------------------------------------------------------------------------------------------------------- Requirements: 1. Matlab 2- GUROBI OPTIMIZATION Note: Matlab should be directed to Gurobi directory ---------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------- USAGE: *utlRoulette, selectSubsetVer and Gurobi_optimization are function needed and used in QuadMutex and QuadMutEx_FilesInput QuadMutEx: INPUT : Describtion of QuadMutEx arguments: 1- G: Mutation matrix in a matlab sparse format. Patients have a serial number from 1 to m. Genes have serial number from 1 to n. 2- GenesNames: vector of genes names orderd as in the G sparse matrix(from 1 to n). 3- t: Integer number of iterations desired. 4- n: Integer number of genes to be included in the submatrix G' each iteration. Each iteration a matrix G' is chosen rendomly from the big matrix G. 5- c: Parameter c (As c gets bigger as the number of genes in solution shrinks). 6- k: Parameter k (High value of k panalize for overlap). 7- GenesSelProb: (optional) vector of probabilities of each gene to be chosen randomly.The probabilities should be in one column orderd as created serial number in the G_file(from 1 to n). The sum of the colmn should be equal 1. Note: If left empty then each gene will have equal chance to be chosen OUTPUT: objective_function: Solution score that is the objective function we want to minimize. x: Selected genes numbers as given and orderd in the sparse matrix solutionSet: names of selected genes see also QuadMutEx_Example.m
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