diff --git a/.changes/1.16.50.json b/.changes/1.16.50.json
new file mode 100644
index 0000000000..713a545d50
--- /dev/null
+++ b/.changes/1.16.50.json
@@ -0,0 +1,17 @@
+[
+  {
+    "category": "``autoscaling``", 
+    "description": "[``botocore``] Update autoscaling client to latest version", 
+    "type": "api-change"
+  }, 
+  {
+    "category": "``transfer``", 
+    "description": "[``botocore``] Update transfer client to latest version", 
+    "type": "api-change"
+  }, 
+  {
+    "category": "``autoscaling-plans``", 
+    "description": "[``botocore``] Update autoscaling-plans client to latest version", 
+    "type": "api-change"
+  }
+]
\ No newline at end of file
diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index 5cb8178786..bee197e7a3 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -2,6 +2,14 @@
 CHANGELOG
 =========
 
+1.16.50
+=======
+
+* api-change:``autoscaling``: [``botocore``] Update autoscaling client to latest version
+* api-change:``transfer``: [``botocore``] Update transfer client to latest version
+* api-change:``autoscaling-plans``: [``botocore``] Update autoscaling-plans client to latest version
+
+
 1.16.49
 =======
 
diff --git a/boto3/__init__.py b/boto3/__init__.py
index 0d7319875c..bb7e442c0a 100644
--- a/boto3/__init__.py
+++ b/boto3/__init__.py
@@ -18,7 +18,7 @@
 
 
 __author__ = 'Amazon Web Services'
-__version__ = '1.16.49'
+__version__ = '1.16.50'
 
 
 # The default Boto3 session; autoloaded when needed.
diff --git a/setup.cfg b/setup.cfg
index 98747a0d0d..b71623c023 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -3,6 +3,6 @@ universal = 1
 
 [metadata]
 requires-dist =
-    botocore>=1.19.49,<1.20.0
+    botocore>=1.19.50,<1.20.0
     jmespath>=0.7.1,<1.0.0
     s3transfer>=0.3.0,<0.4.0
diff --git a/setup.py b/setup.py
index 4f271dc866..e9b618eb23 100644
--- a/setup.py
+++ b/setup.py
@@ -14,7 +14,7 @@
 
 
 requires = [
-    'botocore>=1.19.49,<1.20.0',
+    'botocore>=1.19.50,<1.20.0',
     'jmespath>=0.7.1,<1.0.0',
     's3transfer>=0.3.0,<0.4.0'
 ]