power estimation for microbiome studies analyzed with pairwise distances and PERMANOVA
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DESCRIPTION
NAMESPACE
README.md
micropower_0.4.Rproj

README.md

micropower

The micropower package is designed to facilitate power estimation for microbiome studies that will be analyzed with pairwise distances (beta diversity) and PERMANOVA (a non-parametric extension of multivariate analysis of variance to a matrix of pairwise distances).

It includes:

  • tools to perform distance matrix simulation to model within-group pairwise distances according to pre-specified population parameters
  • a method to incorporate effects of different sizes within a simulated distance matrix
  • a bootstrap method for estimating PERMANOVA power from simulated distance matrices

A detailed description of the methods underlying the micropower package has been submitted for publication. Please see: Kelly BJ, Gross R, Bittinger K, Sherrill-Mix S, Lewis JD, Collman RG, Li H, Bushman FD. Power and sample-size estimation for microbiome studies using pairwise distances and PERMANOVA.