diff --git a/dev-packages/browser-integration-tests/suites/public-api/withScope/throwError/subject.js b/dev-packages/browser-integration-tests/suites/public-api/withScope/throwError/subject.js
new file mode 100644
index 000000000000..67cc16af1d40
--- /dev/null
+++ b/dev-packages/browser-integration-tests/suites/public-api/withScope/throwError/subject.js
@@ -0,0 +1,7 @@
+Sentry.setTag('global', 'tag');
+setTimeout(() => {
+  Sentry.withScope(scope => {
+    scope.setTag('local', 'tag');
+    throw new Error('test error');
+  });
+}, 10);
diff --git a/dev-packages/browser-integration-tests/suites/public-api/withScope/throwError/test.ts b/dev-packages/browser-integration-tests/suites/public-api/withScope/throwError/test.ts
new file mode 100644
index 000000000000..cb21bebb8241
--- /dev/null
+++ b/dev-packages/browser-integration-tests/suites/public-api/withScope/throwError/test.ts
@@ -0,0 +1,33 @@
+import { expect } from '@playwright/test';
+import type { Event } from '@sentry/types';
+
+import { sentryTest } from '../../../../utils/fixtures';
+import { getFirstSentryEnvelopeRequest } from '../../../../utils/helpers';
+
+/**
+ * Why does this test exist?
+ *
+ * We recently discovered that errors caught by global handlers will potentially loose scope data from the active scope
+ * where the error was thrown in. The simple example in this test (see subject.ts) demonstrates this behavior (in a
+ * browser environment but the same behavior applies to the server; see the test there).
+ *
+ * This test nevertheless covers the behavior so that we're aware.
+ */
+sentryTest(
+  'withScope scope is NOT applied to thrown error caught by global handler',
+  async ({ getLocalTestPath, page }) => {
+    const url = await getLocalTestPath({ testDir: __dirname });
+
+    const eventData = await getFirstSentryEnvelopeRequest<Event>(page, url);
+
+    const ex = eventData.exception?.values ? eventData.exception.values[0] : undefined;
+
+    // This tag is missing :(
+    expect(eventData.tags?.local).toBeUndefined();
+
+    expect(eventData.tags).toMatchObject({
+      global: 'tag',
+    });
+    expect(ex?.value).toBe('test error');
+  },
+);
diff --git a/dev-packages/node-integration-tests/suites/express/handle-error-scope-data-loss/server.ts b/dev-packages/node-integration-tests/suites/express/handle-error-scope-data-loss/server.ts
new file mode 100644
index 000000000000..ad45cd5d6713
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/express/handle-error-scope-data-loss/server.ts
@@ -0,0 +1,31 @@
+import { loggingTransport, startExpressServerAndSendPortToRunner } from '@sentry-internal/node-integration-tests';
+import * as Sentry from '@sentry/node-experimental';
+import express from 'express';
+
+const app = express();
+
+Sentry.init({
+  dsn: 'https://public@dsn.ingest.sentry.io/1337',
+  release: '1.0',
+  transport: loggingTransport,
+});
+
+app.use(Sentry.Handlers.requestHandler());
+
+Sentry.setTag('global', 'tag');
+
+app.get('/test/withScope', () => {
+  Sentry.withScope(scope => {
+    scope.setTag('local', 'tag');
+    throw new Error('test_error');
+  });
+});
+
+app.get('/test/isolationScope', () => {
+  Sentry.getIsolationScope().setTag('isolation-scope', 'tag');
+  throw new Error('isolation_test_error');
+});
+
+app.use(Sentry.Handlers.errorHandler());
+
+startExpressServerAndSendPortToRunner(app);
diff --git a/dev-packages/node-integration-tests/suites/express/handle-error-scope-data-loss/test.ts b/dev-packages/node-integration-tests/suites/express/handle-error-scope-data-loss/test.ts
new file mode 100644
index 000000000000..f1bb9a1229b1
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/express/handle-error-scope-data-loss/test.ts
@@ -0,0 +1,89 @@
+import { cleanupChildProcesses, createRunner } from '../../../utils/runner';
+
+afterAll(() => {
+  cleanupChildProcesses();
+});
+
+/**
+ * Why does this test exist?
+ *
+ * We recently discovered that errors caught by global handlers will potentially loose scope data from the active scope
+ * where the error was originally thrown in. The simple example in this test (see subject.ts) demonstrates this behavior
+ * (in a Node environment but the same behavior applies to the browser; see the test there).
+ *
+ * This test nevertheless covers the behavior so that we're aware.
+ */
+test('withScope scope is NOT applied to thrown error caught by global handler', done => {
+  const runner = createRunner(__dirname, 'server.ts')
+    .ignore('session', 'sessions')
+    .expect({
+      event: {
+        exception: {
+          values: [
+            {
+              mechanism: {
+                type: 'middleware',
+                handled: false,
+              },
+              type: 'Error',
+              value: 'test_error',
+              stacktrace: {
+                frames: expect.arrayContaining([
+                  expect.objectContaining({
+                    function: expect.any(String),
+                    lineno: expect.any(Number),
+                    colno: expect.any(Number),
+                  }),
+                ]),
+              },
+            },
+          ],
+        },
+        // 'local' tag is not applied to the event
+        tags: expect.not.objectContaining({ local: expect.anything() }),
+      },
+    })
+    .start(done);
+
+  expect(() => runner.makeRequest('get', '/test/withScope')).rejects.toThrow();
+});
+
+/**
+ * This test shows that the isolation scope set tags are applied correctly to the error.
+ */
+test('isolation scope is applied to thrown error caught by global handler', done => {
+  const runner = createRunner(__dirname, 'server.ts')
+    .ignore('session', 'sessions')
+    .expect({
+      event: {
+        exception: {
+          values: [
+            {
+              mechanism: {
+                type: 'middleware',
+                handled: false,
+              },
+              type: 'Error',
+              value: 'isolation_test_error',
+              stacktrace: {
+                frames: expect.arrayContaining([
+                  expect.objectContaining({
+                    function: expect.any(String),
+                    lineno: expect.any(Number),
+                    colno: expect.any(Number),
+                  }),
+                ]),
+              },
+            },
+          ],
+        },
+        tags: {
+          global: 'tag',
+          'isolation-scope': 'tag',
+        },
+      },
+    })
+    .start(done);
+
+  expect(() => runner.makeRequest('get', '/test/isolationScope')).rejects.toThrow();
+});