Single-level and multi-level mediation analyses for any kind of data, with bootstrap-based significance testing. Neuroimaging-oriented functions allow for mediation effect parametric mapping (mapping of mediation effects across the brain) and multivariate mediation.
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Mediation_walkthrough
PDM_toolbox
geom2d
mediation_toolbox
.DS_Store
M3_Toolbox_Citation.txt
Mediation_help_11_6_08.pdf
README.md

README.md

MediationToolbox

Getting started: See WIKI at wagerlab.colorado.edu There is also a help document PDF in MediationToolbox folder

: mediationanalysis.com, mediationanalysis.org

======= For single- and multi-level mediation search tools.

Docmentation available here.

A walkthrough-example is available here

For the high-dimensional mediation analysis, see here

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Citing: The key papers describing the toolbox are below. It would be helpful to cite these papers when using the M3 toolbox. The manuscripts and supplementary information contain fairly complete descriptions of the model and statistical procedures used.

Wager, T. D., Davidson, M. L., Hughes, B. L., Lindquist, M. A., & Ochsner, K. N. (2008). Prefrontal-subcortical pathways mediating successful emotion regulation. Neuron, 59(6), 1037-1050. doi:10.1016/j.neuron.2008.09.006

Wager, T. D., Waugh, C. E., Lindquist, M., Noll, D. C., Fredrickson, B. L., & Taylor, S. F. (2009). Brain mediators of cardiovascular responses to social threat, Part I: Reciprocal dorsal and ventral sub-regions of the medial prefrontal cortex and heart-rate reactivity. NeuroImage, 47, 821-835.

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Here is a sample of papers using the M3 mediation toolbox. If you know of others we should include, please let us know!

Kober, H., Barrett, L. F., Joseph, J., Bliss-Moreau, E., Lindquist, K., & Wager, T. D. (2008). Functional grouping and cortical-subcortical interactions in emotion: A meta-analysis of neuroimaging studies. NeuroImage, 42, 998-1031.

Wager, T. D., Davidson, M. L., Hughes, B. L., Lindquist, M. A., & Ochsner, K. N. (2008). Prefrontal-subcortical pathways mediating successful emotion regulation. Neuron, 59(6), 1037-1050. doi:10.1016/j.neuron.2008.09.006

Lim, S.-L., Padmala, S., & Pessoa, L. (2009). Segregating the significant from the mundane on a moment-to-moment basis via direct and indirect amygdala contributions. Proceedings of the National Academy of Sciences, 106(39), 16841-16846.

Wager, T. D., Waugh, C. E., Lindquist, M., Noll, D. C., Fredrickson, B. L., & Taylor, S. F. (2009). Brain mediators of cardiovascular responses to social threat, Part I: Reciprocal dorsal and ventral sub-regions of the medial prefrontal cortex and heart-rate reactivity. NeuroImage, 47, 821-835.

Wager, T. D., van Ast, V. A., Hughes, B. L., Davidson, M. L., Lindquist, M. A., & Ochsner, K. N. (2009). Brain mediators of cardiovascular responses to social threat, Part II: Prefrontal-subcortical pathways and relationship with anxiety. NeuroImage, 47, 836-851.

Atlas, L. Y., Bolger, N., Lindquist, M. A., & Wager, T. D. (2010). Brain mediators of predictive cue effects on perceived pain. J Neurosci, 30(39), 12964-12977. doi:10.1523/JNEUROSCI.0057-10.2010

Buhle, J., & Wager, T. D. (2010). Performance-dependent inhibition of pain by an executive working memory task. Pain, 149(1), 19-26. doi:10.1016/j.pain.2009.10.027

Kober, H., Mende-Siedlecki, P., Kross, E. F., Weber, J., Mischel, W., Hart, C. L., & Ochsner, K. N. (2010). Prefrontal–striatal pathway underlies cognitive regulation of craving. Proceedings of the National Academy of Sciences, 107(33), 14811-14816.

Krawitz, A., Fukunaga, R., & Brown, J. W. (2010). Anterior insula activity predicts the influence of positively framed messages on decision making. Cognitive, Affective, & Behavioral Neuroscience, 10(3), 392-405.

Chen, C., Yang, C.-Y., & Cheng, Y. (2012). Sensorimotor resonance is an outcome but not a platform to anticipating harm to others. Social neuroscience, 7(6), 578-590.

Johnston, N. E., Atlas, L. Y., & Wager, T. D. (2012). Opposing effects of expectancy and somatic focus on pain. PLoS One, 7(6), e38854. doi:10.1371/journal.pone.0038854

Schneider, S., Peters, J., Bromberg, U., Brassen, S., Miedl, S. F., Banaschewski, T., . . . Garavan, H. (2012). Risk taking and the adolescent reward system: a potential common link to substance abuse. American Journal of Psychiatry.

Atlas, L. Y., Lindquist, M. A., Bolger, N., & Wager, T. D. (2014). Brain mediators of the effects of noxious heat on pain. Pain, 155(8), 1632-1648. doi:10.1016/j.pain.2014.05.015

Denny, B. T., Ochsner, K. N., Weber, J., & Wager, T. D. (2014). Anticipatory brain activity predicts the success or failure of subsequent emotion regulation. Social cognitive and affective neuroscience, 9(4), 403-411. doi:10.1093/scan/nss148

Fan, Y.-T., Chen, C., Chen, S.-C., Decety, J., & Cheng, Y. (2014). Empathic arousal and social understanding in individuals with autism: evidence from fMRI and ERP measurements. Social cognitive and affective neuroscience, 9(8), 1203-1213.

Cremers, H. R., Veer, I. M., Spinhoven, P., Rombouts, S. A., Yarkoni, T., Wager, T. D., & Roelofs, K. (2015). Altered cortical-amygdala coupling in social anxiety disorder during the anticipation of giving a public speech. Psychol Med, 45(7), 1521-1529. doi:10.1017/S0033291714002657

Woo, C. W., Roy, M., Buhle, J. T., & Wager, T. D. (2015). Distinct brain systems mediate the effects of nociceptive input and self-regulation on pain. PLoS biology, 13(1), e1002036. doi:10.1371/journal.pbio.1002036

Yamamoto, D. J., Woo, C. W., Wager, T. D., Regner, M. F., & Tanabe, J. (2015). Influence of dorsolateral prefrontal cortex and ventral striatum on risk avoidance in addiction: a mediation analysis. Drug Alcohol Depend, 149, 10-17. doi:10.1016/j.drugalcdep.2014.12.026

López-Solà, M., Woo, C.-W., Pujol, J., Deus, J., Harrison, B. J., Monfort, J., & Wager, T. D. (2016). Towards a neurophysiological signature for fibromyalgia. Pain.

Vachon-Presseau, E., Roy, M., Woo, C.-W., Kunz, M., Martel, M.-O., Sullivan, M. J., . . . Rainville, P. (2016). Multiple faces of pain: Effects of chronic pain on the brain regulation of facial expression. Pain.

van Ast, V. A., Spicer, J., Smith, E. E., Schmer-Galunder, S., Liberzon, I., Abelson, J. L., & Wager, T. D. (2016). Brain Mechanisms of Social Threat Effects on Working Memory. Cerebral cortex, 26(2), 544-556. doi:10.1093/cercor/bhu206