diff --git a/packages/react/src/components/InlineCheckbox/InlineCheckbox.js b/packages/react/src/components/InlineCheckbox/InlineCheckbox.js
index 662ba416ef90..3d02d247b959 100644
--- a/packages/react/src/components/InlineCheckbox/InlineCheckbox.js
+++ b/packages/react/src/components/InlineCheckbox/InlineCheckbox.js
@@ -38,7 +38,7 @@ const InlineCheckbox = React.forwardRef(function InlineCheckbox(
     disabled,
     id,
     name,
-    onClick,
+    onClick: onClick ? onClickCheckBoxInput : onClick,
     onChange: (evt) => {
       onChange(evt.target.checked, id, evt);
     },
@@ -57,6 +57,14 @@ const InlineCheckbox = React.forwardRef(function InlineCheckbox(
     }
   }, [indeterminate]);
 
+  function onClickCheckBoxInput(evt) {
+    // If the previous "indeterminate" is true, change "checked" to false. If it is not undefined, we're working on `TableSelectAll`
+    if (indeterminate) {
+      evt.target.checked = false;
+    }
+    onClick(evt);
+  }
+
   return (
     <div className={`${prefix}--checkbox--inline`}>
       <input {...inputProps} />