diff --git a/seal/managers.py b/seal/managers.py
index 50dba70..aaba021 100644
--- a/seal/managers.py
+++ b/seal/managers.py
@@ -1,6 +1,7 @@
 from __future__ import unicode_literals
 
 from django.db import models
+from django.db.models.constants import LOOKUP_SEP
 from django.utils.six import string_types
 
 
@@ -23,14 +24,34 @@ def _clone(self, **kwargs):
         clone._sealed = sealed
         return clone
 
+    def _unsealed_prefetch_lookup(self, prefetch_lookup, to_attr=None):
+        """
+        Turn a string prefetch lookup or a Prefetch instance without an
+        explicit queryset into a Prefetch object with an explicit queryset
+        to prevent the prefetching logic from accessing sealed related
+        managers and triggering a SealedObject exception.
+        """
+        if isinstance(prefetch_lookup, string_types):
+            parts = prefetch_lookup.split(LOOKUP_SEP, 1)
+            if len(parts) > 1:
+                head, tail = parts
+            else:
+                head, tail = parts[0], None
+            queryset = self.model._meta.get_field(head).remote_field.model._default_manager.all()
+            if tail:
+                queryset = queryset.prefetch_related(tail)
+            return models.Prefetch(head, queryset, to_attr=to_attr)
+        elif isinstance(prefetch_lookup, models.Prefetch) and prefetch_lookup.queryset is None:
+            return self._unsealed_prefetch_lookup(
+                prefetch_lookup.prefetch_through,
+                to_attr=prefetch_lookup.to_attr,
+            )
+        return prefetch_lookup
+
     def seal(self):
         clone = self._clone(_sealed=True)
         clone._prefetch_related_lookups = tuple(
-            models.Prefetch(
-                lookup,
-                self.model._meta.get_field(lookup).remote_field.model._default_manager.all(),
-            ) if isinstance(lookup, string_types) else lookup
-            for lookup in clone._prefetch_related_lookups
+            self._unsealed_prefetch_lookup(looukp) for looukp in clone._prefetch_related_lookups
         )
         if issubclass(clone._iterable_class, models.query.ModelIterable):
             clone._iterable_class = SealedModelIterable
diff --git a/tests/test_managers.py b/tests/test_managers.py
index d200f1a..b76e57b 100644
--- a/tests/test_managers.py
+++ b/tests/test_managers.py
@@ -1,3 +1,4 @@
+from django.db.models import Prefetch
 from django.test import TestCase
 from seal.exceptions import SealedObject
 
@@ -48,9 +49,54 @@ def test_not_sealed_many_to_many(self):
         instance = SeaLion.objects.get()
         self.assertSequenceEqual(instance.previous_locations.all(), [self.location])
 
-    def test_sealed_prefetched_many_to_many(self):
+    def test_sealed_string_prefetched_many_to_many(self):
         instance = SeaLion.objects.prefetch_related('previous_locations').seal().get()
-        self.assertSequenceEqual(instance.previous_locations.all(), [self.location])
+        with self.assertNumQueries(0):
+            self.assertSequenceEqual(instance.previous_locations.all(), [self.location])
+
+    def test_sealed_prefetch_prefetched_many_to_many(self):
+        instance = SeaLion.objects.prefetch_related(
+            Prefetch('previous_locations'),
+        ).seal().get()
+        with self.assertNumQueries(0):
+            self.assertSequenceEqual(instance.previous_locations.all(), [self.location])
+
+    def test_sealed_prefetch_queryset_prefetched_many_to_many(self):
+        instance = SeaLion.objects.prefetch_related(
+            Prefetch('previous_locations', Location.objects.all()),
+        ).seal().get()
+        with self.assertNumQueries(0):
+            self.assertSequenceEqual(instance.previous_locations.all(), [self.location])
+
+    def test_sealed_string_prefetched_nested_many_to_many(self):
+        instance = SeaLion.objects.prefetch_related('previous_locations__previous_visitors').seal().get()
+        with self.assertNumQueries(0):
+            self.assertSequenceEqual(instance.previous_locations.all(), [self.location])
+            self.assertSequenceEqual(
+                instance.previous_locations.all()[0].previous_visitors.all(), [self.sealion]
+            )
+
+    def test_sealed_prefetch_prefetched_nested_many_to_many(self):
+        instance = SeaLion.objects.prefetch_related(
+            Prefetch('previous_locations__previous_visitors'),
+        ).seal().get()
+        with self.assertNumQueries(0):
+            self.assertSequenceEqual(instance.previous_locations.all(), [self.location])
+            self.assertSequenceEqual(
+                instance.previous_locations.all()[0].previous_visitors.all(), [self.sealion]
+            )
+
+    def test_prefetched_sealed_many_to_many(self):
+        instance = SeaLion.objects.prefetch_related(
+            Prefetch('previous_locations', Location.objects.seal()),
+        ).get()
+        with self.assertNumQueries(0):
+            self.assertSequenceEqual(instance.previous_locations.all(), [self.location])
+        message = 'Cannot fetch many-to-many field previous_visitors on a sealed object.'
+        with self.assertRaisesMessage(SealedObject, message):
+            self.assertSequenceEqual(
+                instance.previous_locations.all()[0].previous_visitors.all(), [self.sealion]
+            )
 
     def test_sealed_deferred_parent_link(self):
         instance = GreatSeaLion.objects.only('pk').seal().get()