diff --git a/chrome/browser/extensions/api/autofill_private/autofill_private_api.cc b/chrome/browser/extensions/api/autofill_private/autofill_private_api.cc
index 24bb1396cebcf..a5e1719104d83 100644
--- a/chrome/browser/extensions/api/autofill_private/autofill_private_api.cc
+++ b/chrome/browser/extensions/api/autofill_private/autofill_private_api.cc
@@ -23,6 +23,7 @@
 #include "components/autofill/core/browser/browser_autofill_manager.h"
 #include "components/autofill/core/browser/data_model/autofill_profile.h"
 #include "components/autofill/core/browser/data_model/credit_card.h"
+#include "components/autofill/core/browser/data_model/iban.h"
 #include "components/autofill/core/browser/form_data_importer.h"
 #include "components/autofill/core/browser/payments/local_card_migration_manager.h"
 #include "components/autofill/core/browser/payments/virtual_card_enrollment_flow.h"
@@ -715,6 +716,17 @@ ExtensionFunction::ResponseAction AutofillPrivateGetIbanListFunction::Run() {
       api::autofill_private::GetIbanList::Results::Create(iban_list)));
 }
 
+////////////////////////////////////////////////////////////////////////////////
+// AutofillPrivateIsValidIbanFunction
+
+ExtensionFunction::ResponseAction AutofillPrivateIsValidIbanFunction::Run() {
+  absl::optional<api::autofill_private::IsValidIban::Params> parameters =
+      api::autofill_private::IsValidIban::Params::Create(args());
+  EXTENSION_FUNCTION_VALIDATE(parameters);
+  return RespondNow(WithArguments(
+      autofill::IBAN::IsValid(base::UTF8ToUTF16(parameters->iban_value))));
+}
+
 ////////////////////////////////////////////////////////////////////////////////
 // AutofillPrivateGetUpiIdListFunction
 
diff --git a/chrome/browser/extensions/api/autofill_private/autofill_private_api.h b/chrome/browser/extensions/api/autofill_private/autofill_private_api.h
index 3d207497d1ef5..1ab817f243a06 100644
--- a/chrome/browser/extensions/api/autofill_private/autofill_private_api.h
+++ b/chrome/browser/extensions/api/autofill_private/autofill_private_api.h
@@ -268,6 +268,23 @@ class AutofillPrivateGetIbanListFunction : public ExtensionFunction {
   ResponseAction Run() override;
 };
 
+class AutofillPrivateIsValidIbanFunction : public ExtensionFunction {
+ public:
+  AutofillPrivateIsValidIbanFunction() = default;
+  AutofillPrivateIsValidIbanFunction(
+      const AutofillPrivateIsValidIbanFunction&) = delete;
+  AutofillPrivateIsValidIbanFunction& operator=(
+      const AutofillPrivateIsValidIbanFunction&) = delete;
+  DECLARE_EXTENSION_FUNCTION("autofillPrivate.isValidIban",
+                             AUTOFILLPRIVATE_ISVALIDIBAN)
+
+ protected:
+  ~AutofillPrivateIsValidIbanFunction() override = default;
+
+  // ExtensionFunction overrides.
+  ResponseAction Run() override;
+};
+
 class AutofillPrivateGetUpiIdListFunction : public ExtensionFunction {
  public:
   AutofillPrivateGetUpiIdListFunction() = default;
diff --git a/chrome/browser/extensions/api/autofill_private/autofill_private_apitest.cc b/chrome/browser/extensions/api/autofill_private/autofill_private_apitest.cc
index e275fba21d550..84bc3b6e6b1f7 100644
--- a/chrome/browser/extensions/api/autofill_private/autofill_private_apitest.cc
+++ b/chrome/browser/extensions/api/autofill_private/autofill_private_apitest.cc
@@ -130,4 +130,9 @@ IN_PROC_BROWSER_TEST_P(AutofillPrivateApiTest, removeExistingIban) {
   EXPECT_EQ(1, user_action_tester.GetActionCount("AutofillIbanDeleted"));
 }
 
+IN_PROC_BROWSER_TEST_P(AutofillPrivateApiTest, isValidIban) {
+  base::UserActionTester user_action_tester;
+  EXPECT_TRUE(RunAutofillSubtest("isValidIban")) << message_;
+}
+
 }  // namespace extensions
diff --git a/chrome/browser/resources/settings/autofill_page/iban_edit_dialog.html b/chrome/browser/resources/settings/autofill_page/iban_edit_dialog.html
index 7e6233cff65d5..34024c9e3535d 100644
--- a/chrome/browser/resources/settings/autofill_page/iban_edit_dialog.html
+++ b/chrome/browser/resources/settings/autofill_page/iban_edit_dialog.html
@@ -35,6 +35,7 @@
   <div slot="title">[[title_]]</div>
   <div slot="body">
     <cr-input id="valueInput" label="$i18n{addPaymentMethodIban}"
+        on-input="updateSaveIbanButtonEnablement_"
         value="{{value_}}" autofocus>
     </cr-input>
     <cr-input id="nicknameInput" label="$i18n{ibanNickname}"
@@ -51,8 +52,7 @@
     <cr-button id="cancelButton" class="cancel-button"
         on-click="onCancelButtonClick_">$i18n{cancel}</cr-button>
     <cr-button id="saveButton" class="action-button"
-        on-click="onIbanSaveButtonClick_"
-        disabled="[[!saveIbanEnabled_(value_)]]">
+        on-click="onIbanSaveButtonClick_">
       $i18n{save}
     </cr-button>
   </div>
diff --git a/chrome/browser/resources/settings/autofill_page/iban_edit_dialog.ts b/chrome/browser/resources/settings/autofill_page/iban_edit_dialog.ts
index 145bc941854f0..c677f116a924a 100644
--- a/chrome/browser/resources/settings/autofill_page/iban_edit_dialog.ts
+++ b/chrome/browser/resources/settings/autofill_page/iban_edit_dialog.ts
@@ -23,12 +23,7 @@ import {I18nMixin} from 'chrome://resources/cr_elements/i18n_mixin.js';
 import {PolymerElement} from 'chrome://resources/polymer/v3_0/polymer/polymer_bundled.min.js';
 
 import {getTemplate} from './iban_edit_dialog.html.js';
-
-/**
- * Regular expression for valid IBAN value.
- */
-const IBAN_VALID_REGEX: RegExp = new RegExp(
-    '^[a-zA-Z]{2}[0-9]{2}[a-zA-Z0-9]{4}[0-9]{7}([a-zA-Z0-9]?){0,16}$');
+import {PaymentsManagerImpl, PaymentsManagerProxy} from './payments_manager_proxy.js';
 
 declare global {
   interface HTMLElementEventMap {
@@ -85,6 +80,8 @@ export class SettingsIbanEditDialogElement extends
   private value_?: string;
   private nickname_?: string;
   private title_: string;
+  private paymentsManager_: PaymentsManagerProxy =
+      PaymentsManagerImpl.getInstance();
 
   override connectedCallback() {
     super.connectedCallback();
@@ -94,6 +91,7 @@ export class SettingsIbanEditDialogElement extends
       this.value_ = this.iban.value;
       this.nickname_ = this.iban.nickname;
     }
+    this.$.saveButton.disabled = true;
     this.$.dialog.showModal();
   }
 
@@ -123,16 +121,24 @@ export class SettingsIbanEditDialogElement extends
     this.close();
   }
 
-  private saveIbanEnabled_(): boolean {
+  private updateSaveIbanButtonEnablement_() {
+    this.isValidIban().then(isValid => {
+      this.$.saveButton.disabled = !isValid;
+    });
+  }
+
+  private async isValidIban(): Promise<boolean> {
     if (!this.value_) {
-      return false;
+      return Promise.resolve(false);
     }
     // The save button is enabled if the value of the IBAN is invalid (after
     // removing all whitespace from it).
-    const ibanWithoutWhitespace = this.value_.replace(/\s/g, '');
-    return !!IBAN_VALID_REGEX.test(ibanWithoutWhitespace!);
+    const isValid = await this.paymentsManager_.isValidIban(
+        this.value_!.replace(/\s/g, ''));
+    return isValid;
   }
 
+
   /**
    * @param  nickname of the IBAN, undefined when not set.
    * @return nickname character length.
diff --git a/chrome/browser/resources/settings/autofill_page/payments_manager_proxy.ts b/chrome/browser/resources/settings/autofill_page/payments_manager_proxy.ts
index ba075925c0003..444e657c03177 100644
--- a/chrome/browser/resources/settings/autofill_page/payments_manager_proxy.ts
+++ b/chrome/browser/resources/settings/autofill_page/payments_manager_proxy.ts
@@ -29,6 +29,9 @@ export interface PaymentsManagerProxy {
    */
   getIbanList(): Promise<chrome.autofillPrivate.IbanEntry[]>;
 
+  /** @param ibanValue Returns true if the given ibanValue is valid. */
+  isValidIban(ibanValue: string): Promise<boolean>;
+
   /** @param guid The GUID of the credit card to remove. */
   removeCreditCard(guid: string): void;
 
@@ -106,6 +109,10 @@ export class PaymentsManagerImpl implements PaymentsManagerProxy {
     return chrome.autofillPrivate.getIbanList();
   }
 
+  isValidIban(ibanValue: string) {
+    return chrome.autofillPrivate.isValidIban(ibanValue);
+  }
+
   removeCreditCard(guid: string) {
     chrome.autofillPrivate.removeEntry(guid);
   }
diff --git a/chrome/common/extensions/api/autofill_private.idl b/chrome/common/extensions/api/autofill_private.idl
index 807c875c0261b..b839b8e74becc 100644
--- a/chrome/common/extensions/api/autofill_private.idl
+++ b/chrome/common/extensions/api/autofill_private.idl
@@ -245,6 +245,7 @@ namespace autofillPrivate {
   callback GetCreditCardListCallback = void(CreditCardEntry[] entries);
   callback GetIbanListCallback = void(IbanEntry[] entries);
   callback GetUpiIdListCallback = void(DOMString[] entries);
+  callback IsValidIbanCallback = void(boolean isValid);
 
   interface Functions {
     // Gets currently signed-in user profile info, no value is returned if
@@ -310,6 +311,12 @@ namespace autofillPrivate {
     [supportsPromises] static void getIbanList(
         GetIbanListCallback callback);
 
+    // Returns true if the given `ibanValue` is a valid IBAN.
+    // `callback`: Callback which will be called with the result of IBAN
+    // validation.
+    [supportsPromises] static void isValidIban(
+        DOMString ibanValue, IsValidIbanCallback callback);
+
     // Clears the data associated with a wallet card which was saved
     // locally so that the saved copy is masked (e.g., "Card ending
     // in 1234").
diff --git a/chrome/test/data/extensions/api_test/autofill_private/test.js b/chrome/test/data/extensions/api_test/autofill_private/test.js
index 5f98f5e10632e..54878e49ed2f9 100644
--- a/chrome/test/data/extensions/api_test/autofill_private/test.js
+++ b/chrome/test/data/extensions/api_test/autofill_private/test.js
@@ -22,6 +22,7 @@ var NUMBER = '4111 1111 1111 1111';
 var EXP_MONTH = '02';
 var EXP_YEAR = '2999';
 var IBAN_VALUE = 'AD1400080001001234567890';
+var INVALID_IBAN_VALUE = 'AD14000800010012345678900';
 
 var failOnceCalled = function() {
   chrome.test.fail();
@@ -524,6 +525,22 @@ var availableTests = [
       countryCode: COUNTRY_CODE
     }, handler1);
   },
+
+  function isValidIban() {
+    var handler1 = function(isValidIban) {
+      // IBAN_VALUE should be valid, then follow up with invalid value.
+      chrome.test.assertTrue(isValidIban);
+      chrome.autofillPrivate.isValidIban(INVALID_IBAN_VALUE, handler2);
+    }
+
+    var handler2 = function(isValidIban) {
+      // INVALID_IBAN_VALUE is not valid.
+      chrome.test.assertFalse(isValidIban);
+      chrome.test.succeed();
+    }
+
+    chrome.autofillPrivate.isValidIban(IBAN_VALUE, handler1);
+  },
 ];
 
 /** @const */
@@ -535,13 +552,14 @@ var TESTS_FOR_CONFIG = {
   ],
   'addNewIbanNoNickname': ['addNewIbanNoNickname'],
   'addNewIbanWithNickname': ['addNewIbanWithNickname'],
-  'noChangesToExistingIban': ['addNewIbanNoNickname','noChangesToExistingIban'],
-  'updateExistingIbanNoNickname': [
-    'addNewIbanNoNickname', 'updateExistingIban_NoNickname'],
-  'updateExistingIbanWithNickname': [
-    'addNewIbanNoNickname', 'updateExistingIban_WithNickname'],
-  'removeExistingIban': [
-    'addNewIbanNoNickname', 'removeExistingIban'],
+  'noChangesToExistingIban':
+      ['addNewIbanNoNickname', 'noChangesToExistingIban'],
+  'updateExistingIbanNoNickname':
+      ['addNewIbanNoNickname', 'updateExistingIban_NoNickname'],
+  'updateExistingIbanWithNickname':
+      ['addNewIbanNoNickname', 'updateExistingIban_WithNickname'],
+  'removeExistingIban': ['addNewIbanNoNickname', 'removeExistingIban'],
+  'isValidIban': ['isValidIban'],
 };
 
 chrome.test.getConfig(function(config) {
diff --git a/chrome/test/data/webui/settings/passwords_and_autofill_fake_data.ts b/chrome/test/data/webui/settings/passwords_and_autofill_fake_data.ts
index 24df134b65867..40bd6e82940e0 100644
--- a/chrome/test/data/webui/settings/passwords_and_autofill_fake_data.ts
+++ b/chrome/test/data/webui/settings/passwords_and_autofill_fake_data.ts
@@ -506,6 +506,7 @@ export class PaymentsManagerExpectations {
   addedVirtualCards: number = 0;
   requestedIbans: number = 0;
   removedIbans: number = 0;
+  isValidIban: number = 0;
 }
 
 /**
@@ -535,6 +536,7 @@ export class TestPaymentsManager extends TestBrowserProxy implements
       'removeCreditCard',
       'removeIban',
       'addVirtualCard',
+      'isValidIban',
     ]);
 
     // Set these to have non-empty data.
@@ -602,6 +604,11 @@ export class TestPaymentsManager extends TestBrowserProxy implements
     return Promise.resolve(this.data.ibans);
   }
 
+  isValidIban(_ibanValue: string) {
+    this.methodCalled('isValidIban');
+    return Promise.resolve(true);
+  }
+
 
   setIsUserVerifyingPlatformAuthenticatorAvailable(available: boolean|null) {
     this.isUserVerifyingPlatformAuthenticatorAvailable_ = available;
diff --git a/chrome/test/data/webui/settings/payments_section_iban_test.ts b/chrome/test/data/webui/settings/payments_section_iban_test.ts
index ae4c04a08f149..cb6d5f3d6c6d0 100644
--- a/chrome/test/data/webui/settings/payments_section_iban_test.ts
+++ b/chrome/test/data/webui/settings/payments_section_iban_test.ts
@@ -4,7 +4,7 @@
 
 // clang-format off
 import {flush} from 'chrome://resources/polymer/v3_0/polymer/polymer_bundled.min.js';
-import {PaymentsManagerImpl, SettingsIbanEditDialogElement} from 'chrome://settings/lazy_load.js';
+import {CrInputElement, PaymentsManagerImpl, SettingsIbanEditDialogElement} from 'chrome://settings/lazy_load.js';
 import {CrButtonElement, loadTimeData} from 'chrome://settings/settings.js';
 import {assertEquals, assertFalse, assertTrue} from 'chrome://webui-test/chai_assert.js';
 import {eventToPromise, whenAttributeIs} from 'chrome://webui-test/test_util.js';
@@ -14,6 +14,16 @@ import {createPaymentsSection, getDefaultExpectations} from './payments_section_
 
 // clang-format on
 
+/**
+ * Helper function to update IBAN value in the IBAN field.
+ */
+function updateIbanTextboxValue(valueInput: CrInputElement, value: string) {
+  valueInput.value = value;
+  valueInput.dispatchEvent(
+      new CustomEvent('input', {bubbles: true, composed: true}));
+}
+
+
 suite('PaymentsSectionIban', function() {
   setup(function() {
     document.body.innerHTML = window.trustedTypes!.emptyHTML;
@@ -26,7 +36,7 @@ suite('PaymentsSectionIban', function() {
   });
 
   /**
-   * Creates the Edit IBAN dialog.
+   * Creates the Add or Edit IBAN dialog.
    */
   function createIbanDialog(ibanItem: chrome.autofillPrivate.IbanEntry):
       SettingsIbanEditDialogElement {
@@ -34,6 +44,7 @@ suite('PaymentsSectionIban', function() {
     dialog.iban = ibanItem;
     document.body.appendChild(dialog);
     flush();
+    dialog.$.saveButton.disabled = false;
     return dialog;
   }
 
@@ -135,29 +146,28 @@ suite('PaymentsSectionIban', function() {
 
     const saveButton = ibanDialog.$.saveButton;
     assertTrue(!!saveButton);
-    // Can't be saved, because there's no value.
-    assertTrue(saveButton.disabled);
 
-    // Add invalid IBAN value.
+    // Add a valid IBAN value.
     const valueInput = ibanDialog.$.valueInput;
-    valueInput.value = '11112222333344445678';
-    flush();
-    // Can't be saved, because the value of IBAN is invalid.
-    assertTrue(saveButton.disabled);
+    updateIbanTextboxValue(valueInput, 'FI1410093000123458');
 
-    // Add valid IBAN value.
-    valueInput.value = 'FI1410093000123458';
-    flush();
-    // Can be saved, because the value of IBAN is valid.
-    assertFalse(saveButton.disabled);
+    // Type in another valid IBAN value.
+    updateIbanTextboxValue(valueInput, 'IT60X0542811101000000123456');
 
     const savePromise = eventToPromise('save-iban', ibanDialog);
     saveButton.click();
     const event = await savePromise;
 
     assertEquals(undefined, event.detail.guid);
-    assertEquals('FI1410093000123458', event.detail.value);
+    assertEquals('IT60X0542811101000000123456', event.detail.value);
     assertEquals('', event.detail.nickname);
+
+    const paymentsManager =
+        PaymentsManagerImpl.getInstance() as TestPaymentsManager;
+    const expectations = getDefaultExpectations();
+    expectations.isValidIban = 2;
+    expectations.listeningCreditCards = 0;
+    paymentsManager.assertExpectations(expectations);
   });
 
   test('verifyIbanEntryIsNotEditedAfterCancel', async function() {
diff --git a/chrome/test/data/webui/settings/payments_section_interactive_test.ts b/chrome/test/data/webui/settings/payments_section_interactive_test.ts
index dab4e7d6e6981..f3dc00e46c6bc 100644
--- a/chrome/test/data/webui/settings/payments_section_interactive_test.ts
+++ b/chrome/test/data/webui/settings/payments_section_interactive_test.ts
@@ -131,6 +131,7 @@ suite('PaymentsSectionCreditCardEditDialogTest', function() {
     const ibanDialog =
         section.shadowRoot!.querySelector('settings-iban-edit-dialog');
     assertTrue(!!ibanDialog);
+    ibanDialog.$.saveButton.disabled = false;
     return ibanDialog!;
   }
 
@@ -191,6 +192,7 @@ suite('PaymentsSectionCreditCardEditDialogTest', function() {
     const ibanDialog =
         section.shadowRoot!.querySelector('settings-iban-edit-dialog');
     assertTrue(!!ibanDialog);
+    ibanDialog.$.saveButton.disabled = false;
     return ibanDialog;
   }
 
diff --git a/chrome/test/data/webui/settings/payments_section_utils.ts b/chrome/test/data/webui/settings/payments_section_utils.ts
index 53fe215cffd07..5446dbcd94fe1 100644
--- a/chrome/test/data/webui/settings/payments_section_utils.ts
+++ b/chrome/test/data/webui/settings/payments_section_utils.ts
@@ -47,6 +47,7 @@ export function getDefaultExpectations(): PaymentsManagerExpectations {
   expected.addedVirtualCards = 0;
   expected.requestedIbans = 1;
   expected.removedIbans = 0;
+  expected.isValidIban = 0;
   return expected;
 }
 
diff --git a/extensions/browser/extension_function_histogram_value.h b/extensions/browser/extension_function_histogram_value.h
index f74be99718d7b..ff9cad3330b70 100644
--- a/extensions/browser/extension_function_histogram_value.h
+++ b/extensions/browser/extension_function_histogram_value.h
@@ -1831,6 +1831,7 @@ enum HistogramValue {
   SMARTCARDPROVIDERPRIVATE_REPORTCONNECTRESULT = 1768,
   SMARTCARDPROVIDERPRIVATE_REPORTDISCONNECTRESULT = 1769,
   WMDESKSPRIVATE_GETDESKBYID = 1770,
+  AUTOFILLPRIVATE_ISVALIDIBAN = 1771,
   // Last entry: Add new entries above, then run:
   // tools/metrics/histograms/update_extension_histograms.py
   ENUM_BOUNDARY
diff --git a/tools/metrics/histograms/enums.xml b/tools/metrics/histograms/enums.xml
index 27480528f8439..2e46c20b35b44 100644
--- a/tools/metrics/histograms/enums.xml
+++ b/tools/metrics/histograms/enums.xml
@@ -36182,6 +36182,7 @@ Called by update_extension_histograms.py.-->
   <int value="1768" label="SMARTCARDPROVIDERPRIVATE_REPORTCONNECTRESULT"/>
   <int value="1769" label="SMARTCARDPROVIDERPRIVATE_REPORTDISCONNECTRESULT"/>
   <int value="1770" label="WMDESKSPRIVATE_GETDESKBYID"/>
+  <int value="1771" label="AUTOFILLPRIVATE_ISVALIDIBAN"/>
 </enum>
 
 <enum name="ExtensionIconState">
diff --git a/tools/typescript/definitions/autofill_private.d.ts b/tools/typescript/definitions/autofill_private.d.ts
index cada1071cf9c3..4a9c9ddcf54ee 100644
--- a/tools/typescript/definitions/autofill_private.d.ts
+++ b/tools/typescript/definitions/autofill_private.d.ts
@@ -123,6 +123,7 @@ declare global {
           params: ValidatePhoneParams): Promise<string[]>;
       export function getCreditCardList(): Promise<CreditCardEntry[]>;
       export function getIbanList(): Promise<IbanEntry[]>;
+      export function isValidIban(ibanValue: string): Promise<boolean>;
       export function maskCreditCard(guid: string): void;
       export function migrateCreditCards(): void;
       export function logServerCardLinkClicked(): void;