IceLogo builds on probability theory to visualize significant conserved sequence patterns in multiple peptide sequence alignments against background (reference) sequence sets that can be tailored to the studied system and the used protocol. The unique advantages of iceLogo compared to other sequence logo creating tools is that iceLogo has a more dynamic nature and is more correct and complete in the analysis of conserved sequence patterns.
Colaert and Helsens et al. Improved visualization of protein consensus sequences by iceLogo. Nature methods (2009) vol. 6 (11) pp. 786-7 ([http://www.ncbi.nlm.nih.gov/pubmed/19876014 pid: 19876014])
Download iceLogo here.
- Human granzyme B substrate sample set (Van Damme et al., MCP 2009)
- NatA example dataset - 163 NatA targets were confirmed by a NatA knockout model (Arnesen et al., PNAS 2009)
Download the manual here.
The iceLogo project is grateful for the support by: