diff --git a/conan/tools/meson/toolchain.py b/conan/tools/meson/toolchain.py
index 67713d76920..d00f29145d6 100644
--- a/conan/tools/meson/toolchain.py
+++ b/conan/tools/meson/toolchain.py
@@ -245,6 +245,11 @@ def __init__(self, conanfile, backend=None, native=False):
             default_comp = "cl"
             default_comp_cpp = "cl"
 
+        # Read configuration for sys_root property (honoring existing conf)
+        self._sys_root = self._conanfile_conf.get("tools.build:sysroot", check_type=str)
+        if self._sys_root:
+            self.properties["sys_root"] = self._sys_root
+
         # Read configuration for compilers
         compilers_by_conf = self._conanfile_conf.get("tools.build:compiler_executables", default={},
                                                      check_type=dict)
@@ -404,10 +409,11 @@ def _get_extra_flags(self):
         linker_scripts = self._conanfile_conf.get("tools.build:linker_scripts", default=[], check_type=list)
         linker_script_flags = ['-T"' + linker_script + '"' for linker_script in linker_scripts]
         defines = [f"-D{d}" for d in self._conanfile.conf.get("tools.build:defines", default=[], check_type=list)]
+        sys_root = [f"--sysroot={self._sys_root}"] if self._sys_root else [""]
         return {
-            "cxxflags": cxxflags,
-            "cflags": cflags,
-            "ldflags": sharedlinkflags + exelinkflags + linker_script_flags,
+            "cxxflags": cxxflags + sys_root,
+            "cflags": cflags + sys_root,
+            "ldflags": sharedlinkflags + exelinkflags + linker_script_flags + sys_root,
             "defines": defines
         }
 
diff --git a/test/functional/toolchains/meson/test_meson.py b/test/functional/toolchains/meson/test_meson.py
index a24f7960058..8298c17b910 100644
--- a/test/functional/toolchains/meson/test_meson.py
+++ b/test/functional/toolchains/meson/test_meson.py
@@ -6,10 +6,10 @@
 
 import pytest
 
-from conans.model.recipe_ref import RecipeReference
 from conan.test.assets.sources import gen_function_cpp, gen_function_h
-from test.functional.toolchains.meson._base import TestMesonBase
 from conan.test.utils.tools import TestClient
+from conans.model.recipe_ref import RecipeReference
+from test.functional.toolchains.meson._base import TestMesonBase
 
 
 class MesonToolchainTest(TestMesonBase):
diff --git a/test/integration/toolchains/meson/test_mesontoolchain.py b/test/integration/toolchains/meson/test_mesontoolchain.py
index b7a2742f774..602b4bb9a43 100644
--- a/test/integration/toolchains/meson/test_mesontoolchain.py
+++ b/test/integration/toolchains/meson/test_mesontoolchain.py
@@ -1,13 +1,14 @@
 import os
 import platform
+import re
 import textwrap
 
 import pytest
 
 from conan.test.assets.genconanfile import GenConanfile
+from conan.test.utils.tools import TestClient
 from conan.tools.files import load
 from conan.tools.meson import MesonToolchain
-from conan.test.utils.tools import TestClient
 
 
 def test_apple_meson_keep_user_custom_flags():
@@ -534,3 +535,51 @@ def test_compiler_path_with_spaces():
     conan_meson_native = client.load("conan_meson_native.ini")
     assert "c = 'c compiler path with spaces'" in conan_meson_native
     assert "cpp = 'cpp compiler path with spaces'" in conan_meson_native
+
+
+def test_meson_sysroot_app():
+    """Testing when users pass tools.build:sysroot on the profile with Meson
+
+    The generated conan_meson_cross.ini needs to contain both sys_root property to fill the
+    PKG_CONFIG_PATH and the compiler flags with --sysroot.
+
+    When cross-building, Meson needs both compiler_executables in the config, otherwise it will fail
+    when running setup.
+    """
+    sysroot = "/my/new/sysroot/path"
+    client = TestClient()
+    profile = textwrap.dedent(f"""
+    [settings]
+    os = Macos
+    arch = armv8
+    compiler = apple-clang
+    compiler.version = 13.0
+    compiler.libcxx = libc++
+
+    [conf]
+    tools.build:sysroot={sysroot}
+    tools.build:verbosity=verbose
+    tools.compilation:verbosity=verbose
+    tools.apple:sdk_path=/my/sdk/path
+    """)
+    profile_build = textwrap.dedent(f"""
+    [settings]
+    os = Macos
+    arch = x86_64
+    compiler = apple-clang
+    compiler.version = 13.0
+    compiler.libcxx = libc++
+    """)
+    client.save({"conanfile.py": GenConanfile(name="hello", version="0.1")
+                .with_settings("os", "arch", "compiler", "build_type")
+                .with_generator("MesonToolchain"),
+                 "build": profile_build,
+                 "host": profile})
+    client.run("install . -pr:h host -pr:b build")
+    # Check the meson configuration file
+    conan_meson = client.load(os.path.join(client.current_folder, "conan_meson_cross.ini"))
+    assert f"sys_root = '{sysroot}'\n" in conan_meson
+    assert re.search(r"c_args =.+--sysroot={}.+".format(sysroot), conan_meson)
+    assert re.search(r"c_link_args =.+--sysroot={}.+".format(sysroot), conan_meson)
+    assert re.search(r"cpp_args =.+--sysroot={}.+".format(sysroot), conan_meson)
+    assert re.search(r"cpp_link_args =.+--sysroot={}.+".format(sysroot), conan_meson)