diff --git a/conda/gateways/connection/session.py b/conda/gateways/connection/session.py
index 48f7ddc17b..14e8896a52 100644
--- a/conda/gateways/connection/session.py
+++ b/conda/gateways/connection/session.py
@@ -170,6 +170,7 @@ def __init__(self, auth: AuthBase | tuple[str, str] | None = None):
                 backoff_factor=context.remote_backoff_factor,
                 status_forcelist=[413, 429, 500, 503],
                 raise_on_status=False,
+                respect_retry_after_header=False,
             )
             http_adapter = HTTPAdapter(max_retries=retry)
             self.mount("http://", http_adapter)
diff --git a/news/13050-ignore-retry-after-header b/news/13050-ignore-retry-after-header
new file mode 100644
index 0000000000..2ee03b4c73
--- /dev/null
+++ b/news/13050-ignore-retry-after-header
@@ -0,0 +1,19 @@
+### Enhancements
+
+* <news item>
+
+### Bug fixes
+
+* Configure conda to ignore "Retry-After" header to avoid the scenarios when this value is very large and causes conda to hang indefinitely. (#13050)
+
+### Deprecations
+
+* <news item>
+
+### Docs
+
+* <news item>
+
+### Other
+
+* <news item>