diff --git a/cachito/web/api_v1.py b/cachito/web/api_v1.py
index 5104930ff..1cf1a28af 100644
--- a/cachito/web/api_v1.py
+++ b/cachito/web/api_v1.py
@@ -336,14 +336,16 @@ def patch_request(request_id):
     request = Request.query.get_or_404(request_id)
     delete_bundle = False
     delete_bundle_temp = False
-    cleanup_nexus = False
+    cleanup_nexus = []
     delete_logs = False
     if "state" in payload and "state_reason" in payload:
         new_state = payload["state"]
         delete_bundle = new_state == "stale" and request.state.state_name != "failed"
-        cleanup_nexus = new_state in ("stale", "failed") and any(
-            p.name == "npm" for p in request.pkg_managers
-        )
+        if new_state in ("stale", "failed"):
+            if any(p.name == "npm" for p in request.pkg_managers):
+                cleanup_nexus.append("npm")
+            if any(p.name == "pip" for p in request.pkg_managers):
+                cleanup_nexus.append("pip")
         delete_bundle_temp = new_state in ("complete", "failed")
         delete_logs = new_state == "stale"
         new_state_reason = payload["state_reason"]
@@ -413,16 +415,18 @@ def patch_request(request_id):
         except:  # noqa E722
             flask.current_app.logger.exception("Failed to delete the log file %s", path_to_file)
 
-    if cleanup_nexus:
+    for pkg_mgr in cleanup_nexus:
         flask.current_app.logger.info(
-            "Cleaning up the Nexus npm content for request %d", request_id
+            "Cleaning up the Nexus %s content for request %d", pkg_mgr, request_id
         )
+        cleanup_task = getattr(tasks, f"cleanup_{pkg_mgr}_request")
         try:
-            tasks.cleanup_npm_request.delay(request_id)
+            cleanup_task.delay(request_id)
         except kombu.exceptions.OperationalError:
             flask.current_app.logger.exception(
-                "Failed to schedule the cleanup_npm_request task for request %d. An administrator "
+                "Failed to schedule the cleanup_%s_request task for request %d. An administrator "
                 "must clean this up manually.",
+                pkg_mgr,
                 request.id,
             )
 
diff --git a/cachito/workers/tasks/pip.py b/cachito/workers/tasks/pip.py
new file mode 100644
index 000000000..a4e87a286
--- /dev/null
+++ b/cachito/workers/tasks/pip.py
@@ -0,0 +1,19 @@
+# SPDX-License-Identifier: GPL-3.0-or-later
+from cachito.workers import nexus
+from cachito.workers.pkg_managers.pip import (
+    get_pypi_hosted_repo_name,
+    get_raw_hosted_repo_name,
+    get_hosted_repositories_username,
+)
+from cachito.workers.tasks.celery import app
+
+
+@app.task
+def cleanup_pip_request(request_id):
+    """Clean up the Nexus Python content for the Cachito request."""
+    payload = {
+        "pip_repository_name": get_pypi_hosted_repo_name(request_id),
+        "raw_repository_name": get_raw_hosted_repo_name(request_id),
+        "username": get_hosted_repositories_username(request_id),
+    }
+    nexus.execute_script("pip_cleanup", payload)
diff --git a/tests/test_workers/test_tasks/test_pip.py b/tests/test_workers/test_tasks/test_pip.py
new file mode 100644
index 000000000..d5afbe3d7
--- /dev/null
+++ b/tests/test_workers/test_tasks/test_pip.py
@@ -0,0 +1,16 @@
+# SPDX-License-Identifier: GPL-3.0-or-later
+from unittest import mock
+
+from cachito.workers.tasks import pip
+
+
+@mock.patch("cachito.workers.tasks.pip.nexus.execute_script")
+def test_cleanup_pip_request(mock_exec_script):
+    pip.cleanup_pip_request(42)
+
+    expected_payload = {
+        "pip_repository_name": "cachito-pip-hosted-42",
+        "raw_repository_name": "cachito-pip-raw-42",
+        "username": "cachito-pip-42",
+    }
+    mock_exec_script.assert_called_once_with("pip_cleanup", expected_payload)