diff --git a/pkg/lib/aws/ec2.go b/pkg/lib/aws/ec2.go
index 9ca9ef36bc..8ae55b0cb8 100644
--- a/pkg/lib/aws/ec2.go
+++ b/pkg/lib/aws/ec2.go
@@ -30,7 +30,10 @@ import (
 	s "github.com/cortexlabs/cortex/pkg/lib/strings"
 )
 
-var _digitsRegex = regexp.MustCompile(`[0-9]+`)
+var (
+	_digitsRegex         = regexp.MustCompile(`[0-9]+`)
+	_gpuInstanceFamilies = strset.New("g", "p")
+)
 
 type ParsedInstanceType struct {
 	Family       string
@@ -117,6 +120,23 @@ func IsARMInstance(instanceType string) (bool, error) {
 	return false, nil
 }
 
+func IsAMDGPUInstance(instanceType string) (bool, error) {
+	parsedType, err := ParseInstanceType(instanceType)
+	if err != nil {
+		return false, err
+	}
+
+	if !_gpuInstanceFamilies.Has(parsedType.Family) {
+		return false, nil
+	}
+
+	if parsedType.Capabilities.Has("a") {
+		return true, nil
+	}
+
+	return false, nil
+}
+
 func (c *Client) SpotInstancePrice(instanceType string) (float64, error) {
 	result, err := c.EC2().DescribeSpotPriceHistory(&ec2.DescribeSpotPriceHistoryInput{
 		InstanceTypes:       []*string{aws.String(instanceType)},
diff --git a/pkg/types/clusterconfig/cluster_config.go b/pkg/types/clusterconfig/cluster_config.go
index cd34c4ff7c..0bac1e602d 100644
--- a/pkg/types/clusterconfig/cluster_config.go
+++ b/pkg/types/clusterconfig/cluster_config.go
@@ -1269,6 +1269,14 @@ func validateInstanceType(instanceType string) (string, error) {
 		return "", ErrorARMInstancesNotSupported(instanceType)
 	}
 
+	isAMDGPU, err := aws.IsAMDGPUInstance(instanceType)
+	if err != nil {
+		return "", err
+	}
+	if isAMDGPU {
+		return "", ErrorAMDGPUInstancesNotSupported(instanceType)
+	}
+
 	if err := checkCNISupport(instanceType); err != nil {
 		return "", err
 	}
diff --git a/pkg/types/clusterconfig/errors.go b/pkg/types/clusterconfig/errors.go
index e238912aab..fa69e95c23 100644
--- a/pkg/types/clusterconfig/errors.go
+++ b/pkg/types/clusterconfig/errors.go
@@ -47,6 +47,7 @@ const (
 	ErrSpotPriceGreaterThanMaxPrice           = "clusterconfig.spot_price_greater_than_max_price"
 	ErrInstanceTypeNotSupportedByCortex       = "clusterconfig.instance_type_not_supported_by_cortex"
 	ErrARMInstancesNotSupported               = "clusterconfig.arm_instances_not_supported"
+	ErrAMDGPUInstancesNotSupported            = "clusterconfig.amd_gpu_instances_not_supported"
 	ErrAtLeastOneInstanceDistribution         = "clusterconfig.at_least_one_instance_distribution"
 	ErrNoCompatibleSpotInstanceFound          = "clusterconfig.no_compatible_spot_instance_found"
 	ErrConfiguredWhenSpotIsNotEnabled         = "clusterconfig.configured_when_spot_is_not_enabled"
@@ -203,7 +204,14 @@ func ErrorInstanceTypeNotSupportedByCortex(instanceType string) error {
 func ErrorARMInstancesNotSupported(instanceType string) error {
 	return errors.WithStack(&errors.Error{
 		Kind:    ErrARMInstancesNotSupported,
-		Message: fmt.Sprintf("ARM-based instances (including %s) are not supported", instanceType),
+		Message: fmt.Sprintf("ARM-based instances (including %s) are not supported by cortex", instanceType),
+	})
+}
+
+func ErrorAMDGPUInstancesNotSupported(instanceType string) error {
+	return errors.WithStack(&errors.Error{
+		Kind:    ErrAMDGPUInstancesNotSupported,
+		Message: fmt.Sprintf("AMD GPU instances (including %s) are not supported by cortex", instanceType),
 	})
 }