diff --git a/lib/rucio/daemons/reaper/reaper.py b/lib/rucio/daemons/reaper/reaper.py
index 4d48772e16..a8f3425245 100644
--- a/lib/rucio/daemons/reaper/reaper.py
+++ b/lib/rucio/daemons/reaper/reaper.py
@@ -38,7 +38,7 @@
 from rucio.common.exception import (DatabaseException, RSENotFound,
                                     ReplicaUnAvailable, ReplicaNotFound, ServiceUnavailable,
                                     RSEAccessDenied, ResourceTemporaryUnavailable, SourceNotFound,
-                                    VONotFound)
+                                    VONotFound, RSEProtocolNotSupported)
 from rucio.common.logging import setup_logging
 from rucio.common.types import InternalAccount
 from rucio.common.stopwatch import Stopwatch
@@ -238,14 +238,18 @@ def delete_from_storage(heartbeat_handler, hb_payload, replicas, prot, rse_info,
     return deleted_files
 
 
-def _rse_deletion_hostname(rse: RseData) -> "Optional[str]":
+def _rse_deletion_hostname(rse: RseData, scheme: "Optional[str]") -> "Optional[str]":
     """
     Retrieves the hostname of the default deletion protocol
     """
     rse.ensure_loaded(load_info=True)
     for prot in rse.info['protocols']:
-        if prot['domains']['wan']['delete'] == 1:
-            return prot['hostname']
+        if scheme:
+            if prot['scheme'] == scheme and prot['domains']['wan']['delete'] != 0:
+                return prot['hostname']
+        else:
+            if prot['domains']['wan']['delete'] == 1:
+                return prot['hostname']
     return None
 
 
@@ -559,9 +563,12 @@ def _run_once(rses_to_process, chunk_size, greedy, scheme,
             percent = needed_free_space / tot_needed_free_space * 100
         logger(logging.DEBUG, 'Working on %s. Percentage of the total space needed %.2f', rse.name, percent)
 
-        rse_hostname = _rse_deletion_hostname(rse)
+        rse_hostname = _rse_deletion_hostname(rse, scheme)
         if not rse_hostname:
-            logger(logging.WARNING, 'No default delete protocol for %s', rse.name)
+            if scheme:
+                logger(logging.WARNING, 'Protocol %s not supported on %s', scheme, rse.name)
+            else:
+                logger(logging.WARNING, 'No default delete protocol for %s', rse.name)
             REGION.set('pause_deletion_%s' % rse.id, True)
             continue
 
@@ -641,6 +648,8 @@ def _run_once(rses_to_process, chunk_size, greedy, scheme,
                 delete_replicas(rse_id=rse.id, files=deleted_files)
                 logger(logging.DEBUG, 'delete_replicas successed on %s : %s replicas in %s seconds', rse.name, len(deleted_files), time.time() - del_start)
                 METRICS.counter('deletion.done').inc(len(deleted_files))
+        except RSEProtocolNotSupported:
+            logger(logging.WARNING, 'Protocol %s not supported on %s', scheme, rse.name)
         except Exception:
             logger(logging.CRITICAL, 'Exception', exc_info=True)
 
diff --git a/lib/rucio/tests/test_reaper.py b/lib/rucio/tests/test_reaper.py
index 4703735d25..3e08362868 100644
--- a/lib/rucio/tests/test_reaper.py
+++ b/lib/rucio/tests/test_reaper.py
@@ -459,3 +459,34 @@ def test_archive_of_deleted_dids(vo, did_factory, root_account, core_config_mock
         print(did)
         deleted_dids.append(did)
     assert len(deleted_dids) == len(dids)
+
+
+@pytest.mark.parametrize("file_config_mock", [
+    # Run test twice: with, and without, temp tables
+    {"overrides": [('core', 'use_temp_tables', 'True')]},
+    {"overrides": [('core', 'use_temp_tables', 'False')]},
+], indirect=True)
+@pytest.mark.parametrize("caches_mock", [{"caches_to_mock": [
+    'rucio.daemons.reaper.reaper.REGION'
+]}], indirect=True)
+def test_run_on_non_existing_scheme(vo, caches_mock, file_config_mock):
+    """ REAPER (DAEMON): Mock test the reaper daemon with a speficied scheme."""
+    [cache_region] = caches_mock
+    scope = InternalScope('data13_hip', vo=vo)
+
+    nb_files = 250
+    file_size = 200  # 2G
+    rse_name, rse_id, dids = __add_test_rse_and_replicas(vo=vo, scope=scope, rse_name=rse_name_generator(),
+                                                         names=['lfn' + generate_uuid() for _ in range(nb_files)], file_size=file_size)
+
+    rse_core.set_rse_limits(rse_id=rse_id, name='MinFreeSpace', value=50 * file_size)
+    assert len(list(replica_core.list_replicas(dids=dids, rse_expression=rse_name))) == nb_files
+
+    # Now put it over threshold and delete
+    # Nothing should be deleted since the protocol doesn't exists for this RSE
+    # The reaper will set a flag pause_deletion_<rse_id>
+    cache_region.invalidate()
+    rse_core.set_rse_usage(rse_id=rse_id, source='storage', used=nb_files * file_size, free=1)
+    reaper(once=True, rses=[], include_rses=rse_name, exclude_rses=None, chunk_size=1000, scheme='https')
+    assert len(list(replica_core.list_replicas(dids, rse_expression=rse_name))) == 250
+    assert cache_region.get('pause_deletion_%s' % rse_id)