diff --git a/cli/apiconfig.go b/cli/apiconfig.go
index 96f76a6..5e069ab 100644
--- a/cli/apiconfig.go
+++ b/cli/apiconfig.go
@@ -32,6 +32,7 @@ type TLSConfig struct {
 
 // APIProfile contains account-specific API information
 type APIProfile struct {
+	Base    string            `json:"base",omitempty`
 	Headers map[string]string `json:"headers,omitempty"`
 	Query   map[string]string `json:"query,omitempty"`
 	Auth    *APIAuth          `json:"auth"`
@@ -189,9 +190,23 @@ func initAPIConfig() {
 
 func findAPI(uri string) (string, *APIConfig) {
 	for name, config := range configs {
-		if strings.HasPrefix(uri, config.Base) {
-			// TODO: find the longest matching base?
-			return name, config
+		profile := viper.GetString("rsh-profile")
+		if profile != "default" {
+			if config.Profiles[profile] == nil {
+				continue
+			}
+			if config.Profiles[profile].Base != "" {
+				if strings.HasPrefix(uri, config.Profiles[profile].Base) {
+					return name, config
+				}
+			} else if strings.HasPrefix(uri, config.Base) {
+				return name, config
+			}
+		} else {
+			if strings.HasPrefix(uri, config.Base) {
+				// TODO: find the longest matching base?
+				return name, config
+			}
 		}
 	}
 
diff --git a/cli/cli.go b/cli/cli.go
index 13906b1..5344356 100644
--- a/cli/cli.go
+++ b/cli/cli.go
@@ -116,7 +116,17 @@ func completeCurrentConfig(cmd *cobra.Command, args []string, toComplete string,
 		for _, cmd := range Root.Commands() {
 			if cmd.Use == currentConfig.name {
 				// This is the matching command. Load the URL and check each operation.
-				api, _ := Load(currentConfig.Base, cmd)
+				currentBase := currentConfig.Base
+				currentProfile := currentConfig.Profiles[viper.GetString("rsh-profile")]
+				if currentProfile == nil {
+					if viper.GetString("rsh-profile") != "default" {
+						panic("Invalid profile " + viper.GetString("rsh-profile"))
+					}
+				}
+				if currentProfile != nil && currentProfile.Base != "" {
+					currentBase = currentProfile.Base
+				}
+				api, _ := Load(currentBase, cmd)
 				for _, op := range api.Operations {
 					if op.Method != method {
 						// We only care about operations which match the currently selected
@@ -679,6 +689,7 @@ func Run() {
 	if headers, _ := GlobalFlags.GetStringSlice("rsh-header"); len(headers) > 0 {
 		viper.Set("rsh-header", headers)
 	}
+	profile, _ := GlobalFlags.GetString("rsh-profile")
 
 	// Now that global flags are parsed we can enable verbose mode if requested.
 	if viper.GetBool("rsh-verbose") {
@@ -704,7 +715,17 @@ func Run() {
 				currentConfig = cfg
 				for _, cmd := range Root.Commands() {
 					if cmd.Use == apiName {
-						if _, err := Load(cfg.Base, cmd); err != nil {
+						currentBase := cfg.Base
+						currentProfile := cfg.Profiles[profile]
+						if currentProfile == nil {
+							if profile != "default" {
+								panic("Invalid profile " + profile)
+							}
+						}
+						if currentProfile != nil && currentProfile.Base != "" {
+							currentBase = currentProfile.Base
+						}
+						if _, err := Load(currentBase, cmd); err != nil {
 							panic(err)
 						}
 						loaded = true
diff --git a/cli/interactive.go b/cli/interactive.go
index c3ac832..eb8f732 100644
--- a/cli/interactive.go
+++ b/cli/interactive.go
@@ -241,6 +241,11 @@ func askEditProfile(a asker, name string, profile *APIProfile) {
 			options = append(options, "Delete query param "+k)
 		}
 
+		options = append(options, "Add custom base URL")
+		if profile.Base != "" {
+			options = append(options, "Remove custom base URL")
+		}
+
 		options = append(options, "Setup auth", "Finished with profile")
 
 		choice := a.askSelect("Select option for profile `"+name+"`", options, nil, "")
@@ -275,6 +280,11 @@ func askEditProfile(a asker, name string, profile *APIProfile) {
 				profile.Auth = &APIAuth{}
 			}
 			askAuth(a, profile.Auth)
+		case choice == "Add custom base URL":
+			url := a.askInput("Base URL", "", true, "")
+			profile.Base = url
+		case choice == "Remove custom base URL":
+			profile.Base = ""
 		case choice == "Finished with profile":
 			return
 		}
diff --git a/cli/request.go b/cli/request.go
index 5d0be72..50893dd 100644
--- a/cli/request.go
+++ b/cli/request.go
@@ -26,9 +26,20 @@ func fixAddress(addr string) string {
 		// the base URL for that API.
 		parts := strings.Split(addr, "/")
 		c := configs[parts[0]]
-		if c != nil && c.Base != "" {
-			parts[0] = c.Base
-			return strings.Join(parts, "/")
+		if c != nil {
+			p := c.Profiles[viper.GetString("rsh-profile")]
+			if p == nil {
+				if viper.GetString("rsh-profile") != "default" {
+					panic("Invalid profile " + viper.GetString("rsh-profile"))
+				}
+			}
+			if p != nil && p.Base != "" {
+				parts[0] = p.Base
+				return strings.Join(parts, "/")
+			} else if c.Base != "" {
+				parts[0] = c.Base
+				return strings.Join(parts, "/")
+			}
 		}
 
 		// Local traffic defaults to HTTP, everything else uses TLS.
@@ -82,7 +93,6 @@ func MakeRequest(req *http.Request, options ...requestOption) (*http.Response, e
 		if viper.GetString("rsh-profile") != "default" {
 			panic("Invalid profile " + viper.GetString("rsh-profile"))
 		}
-
 		profile = &APIProfile{}
 	}