Patients stratification with Graph-regularized Non-negative Matrix Factorization (GNMF) in Python.
The minimum required dependencies to run the software are:
- Python >= 3.4
- NumPy >= 1.6
- SciPy >= 0.7.2
- matplotlib >= 0.98.4
- scikit-learn >= 0.19
- pandas >= 0.1
If you want to launch Reproducibility project by Jupyter Notebook, you will also need:
To reproduce the figure 3 of our paper about reproducibility in bioinformatics, you have two options:
~$ mkdir <your_output_folder_outside_stratipy_folder> ~$ docker build -t repro . ~$ docker run -v /absolute/path/of/<your_output_folder_outside_stratipy_folder>:/reproducibility/reproducibility_output repro
For Windows or Mac users: total runtime memory of Docker is fixed to 2 GB by default. In order to launch this project, you have to increase this limit (approximately 7 GB):
- Network-based stratification of tumor mutations (Hofree et al. Nat. Meth. 2013)
- Consensus clustering: a resampling-based method for class discovery and visualization of gene expression microarray data (Monti et al. Mach. Learn.2003)
- Experimenting with reproducibility in bioinformatics (Kim et al. BioRxiv 2017)
- Network Based Stratification (NBS): Matlab code & data sets.
- NMF on Manifold (Graph), Deng Cai: Matlab code & data sets.
- NMF Toolbox: Matlab code.
- nimfa library: Python code.
Stratipy is BSD-licenced (3 clause):
This software is OSI Certified Open Source Software. OSI Certified is a certification mark of the Open Source Initiative. Copyright (c) 2014, authors of Stratipy All rights reserved. Redistribution and use in source and binary forms, with or without modification, are permitted provided that the following conditions are met: * Redistributions of source code must retain the above copyright notice, this list of conditions and the following disclaimer. * Redistributions in binary form must reproduce the above copyright notice, this list of conditions and the following disclaimer in the documentation and/or other materials provided with the distribution. * Neither the names of Stratipy authors nor the names of any contributors may be used to endorse or promote products derived from this software without specific prior written permission. **This software is provided by the copyright holders and contributors "as is" and any express or implied warranties, including, but not limited to, the implied warranties of merchantability and fitness for a particular purpose are disclaimed. In no event shall the copyright owner or contributors be liable for any direct, indirect, incidental, special, exemplary, or consequential damages (including, but not limited to, procurement of substitute goods or services; loss of use, data, or profits; or business interruption) however caused and on any theory of liability, whether in contract, strict liability, or tort (including negligence or otherwise) arising in any way out of the use of this software, even if advised of the possibility of such damage.**