diff --git a/packages/grid/src/Grid.test.tsx b/packages/grid/src/Grid.test.tsx
index ae1452fa0a..db84b493ec 100644
--- a/packages/grid/src/Grid.test.tsx
+++ b/packages/grid/src/Grid.test.tsx
@@ -1181,3 +1181,243 @@ describe('column separators', () => {
     });
   });
 });
+
+describe('grid-block-events cleanup', () => {
+  const resizableTheme = { ...defaultTheme, allowColumnResize: true };
+
+  function getColumnSeparatorX(columnIndex: VisibleIndex): number {
+    const { rowHeaderWidth, columnWidth } = resizableTheme;
+    return rowHeaderWidth + columnWidth * (columnIndex + 1) - 2;
+  }
+
+  function getColumnHeaderY(): number {
+    return Math.floor(resizableTheme.columnHeaderHeight / 2);
+  }
+
+  function hasBlockEventsClass(): boolean {
+    return document.documentElement.classList.contains('grid-block-events');
+  }
+
+  beforeEach(() => {
+    // Ensure clean state before each test
+    document.documentElement.classList.remove('grid-block-events');
+  });
+
+  afterEach(() => {
+    // Clean up after each test
+    document.documentElement.classList.remove('grid-block-events');
+  });
+
+  it('should remove grid-block-events after normal drag and mouse up', () => {
+    const component = makeGridComponent(new MockGridModel(), resizableTheme);
+    const separatorX = getColumnSeparatorX(0);
+    const headerY = getColumnHeaderY();
+
+    expect(hasBlockEventsClass()).toBe(false);
+
+    // Start drag on column separator
+    mouseDown(0, 0, component, {}, separatorX, headerY);
+
+    // Drag to trigger handleMouseDrag which adds the class
+    fireEvent.mouseMove(window, {
+      clientX: separatorX + 50,
+      clientY: headerY,
+    });
+
+    expect(hasBlockEventsClass()).toBe(true);
+
+    // Normal mouse up should clean up
+    fireEvent.mouseUp(window, {
+      clientX: separatorX + 50,
+      clientY: headerY,
+      button: 0,
+    });
+
+    expect(hasBlockEventsClass()).toBe(false);
+  });
+
+  it('should remove grid-block-events when right-clicking during drag (case 1)', () => {
+    const component = makeGridComponent(new MockGridModel(), resizableTheme);
+    const separatorX = getColumnSeparatorX(0);
+    const headerY = getColumnHeaderY();
+
+    // Start drag
+    mouseDown(0, 0, component, {}, separatorX, headerY);
+    fireEvent.mouseMove(window, {
+      clientX: separatorX + 50,
+      clientY: headerY,
+    });
+
+    expect(hasBlockEventsClass()).toBe(true);
+
+    // Right-click during drag (button=2)
+    fireEvent.mouseUp(window, {
+      clientX: separatorX + 50,
+      clientY: headerY,
+      button: 2,
+    });
+
+    // Right-click during drag returns early, class should still be present
+    // Then complete with left mouse up
+    fireEvent.mouseUp(window, {
+      clientX: separatorX + 50,
+      clientY: headerY,
+      button: 0,
+    });
+
+    expect(hasBlockEventsClass()).toBe(false);
+  });
+
+  it('should ignore middle-click during drag and continue dragging (case 2)', () => {
+    const component = makeGridComponent(new MockGridModel(), resizableTheme);
+    const separatorX = getColumnSeparatorX(0);
+    const headerY = getColumnHeaderY();
+
+    // Start drag
+    mouseDown(0, 0, component, {}, separatorX, headerY);
+    fireEvent.mouseMove(window, {
+      clientX: separatorX + 50,
+      clientY: headerY,
+    });
+
+    expect(hasBlockEventsClass()).toBe(true);
+
+    // Middle mouse button up during drag (button=1) should be ignored
+    // Drag should continue
+    fireEvent.mouseUp(window, {
+      clientX: separatorX + 50,
+      clientY: headerY,
+      button: 1,
+    });
+
+    // Class should still be present since drag is ongoing
+    expect(hasBlockEventsClass()).toBe(true);
+
+    // Left mouse up should properly end the drag and clean up
+    fireEvent.mouseUp(window, {
+      clientX: separatorX + 50,
+      clientY: headerY,
+      button: 0,
+    });
+
+    expect(hasBlockEventsClass()).toBe(false);
+  });
+
+  it('should handle addDocumentCursor with null cursor (case 3)', () => {
+    const component = makeGridComponent(new MockGridModel(), resizableTheme);
+
+    expect(hasBlockEventsClass()).toBe(false);
+
+    // First add a real cursor - this sets documentCursor and adds grid-block-events
+    component.addDocumentCursor('move');
+    expect(hasBlockEventsClass()).toBe(true);
+
+    // Now simulate cursor being cleared to null (e.g., mouse handler sets cursor = null)
+    // This sets documentCursor to null but keeps grid-block-events
+    component.addDocumentCursor(null);
+
+    // grid-block-events should still be present since it was added
+    expect(hasBlockEventsClass()).toBe(true);
+
+    // removeDocumentCursor should still clean up
+    // BUG: Currently it doesn't because documentCursor is null and
+    // the entire function body is guarded by `if (this.documentCursor != null)`
+    component.removeDocumentCursor();
+
+    // After fix, this should be false
+    expect(hasBlockEventsClass()).toBe(false);
+  });
+
+  it('should handle multiple Grid instances without interference (case 5)', () => {
+    // Create two grid instances
+    const component1 = makeGridComponent(new MockGridModel(), resizableTheme);
+    const component2 = makeGridComponent(new MockGridModel(), resizableTheme);
+
+    const separatorX = getColumnSeparatorX(0);
+    const headerY = getColumnHeaderY();
+
+    expect(hasBlockEventsClass()).toBe(false);
+
+    // Start drag on Grid 1
+    fireEvent.mouseDown(component1.canvas!, {
+      clientX: separatorX,
+      clientY: headerY,
+    });
+    fireEvent.mouseMove(window, {
+      clientX: separatorX + 50,
+      clientY: headerY,
+    });
+
+    expect(hasBlockEventsClass()).toBe(true);
+
+    // Grid 2 unmounts while Grid 1 is dragging
+    // This simulates closing a panel or tab
+    component2.componentWillUnmount();
+
+    // Grid 2's unmount should NOT affect Grid 1's drag state
+    // The class should still be present for Grid 1
+    expect(hasBlockEventsClass()).toBe(true);
+
+    // Complete Grid 1's drag
+    fireEvent.mouseUp(window, {
+      clientX: separatorX + 50,
+      clientY: headerY,
+      button: 0,
+    });
+
+    expect(hasBlockEventsClass()).toBe(false);
+  });
+
+  it('should clean up grid-block-events when component unmounts during drag (case 6)', () => {
+    const component = makeGridComponent(new MockGridModel(), resizableTheme);
+    const separatorX = getColumnSeparatorX(0);
+    const headerY = getColumnHeaderY();
+
+    // Start drag
+    mouseDown(0, 0, component, {}, separatorX, headerY);
+    fireEvent.mouseMove(window, {
+      clientX: separatorX + 50,
+      clientY: headerY,
+    });
+
+    expect(hasBlockEventsClass()).toBe(true);
+
+    // Component unmounts (simulates user navigating away or closing panel)
+    // This could happen if user drags outside window and releases there
+    component.componentWillUnmount();
+
+    // componentWillUnmount should clean up the class
+    expect(hasBlockEventsClass()).toBe(false);
+  });
+
+  it('should not leave grid-block-events when drag ends outside grid boundaries', () => {
+    const component = makeGridComponent(new MockGridModel(), resizableTheme);
+    const separatorX = getColumnSeparatorX(0);
+    const headerY = getColumnHeaderY();
+
+    // Start drag
+    mouseDown(0, 0, component, {}, separatorX, headerY);
+    fireEvent.mouseMove(window, {
+      clientX: separatorX + 50,
+      clientY: headerY,
+    });
+
+    expect(hasBlockEventsClass()).toBe(true);
+
+    // Move mouse far outside grid (simulating dragging outside window)
+    fireEvent.mouseMove(window, {
+      clientX: -1000,
+      clientY: -1000,
+    });
+
+    // Mouse up outside grid boundaries
+    fireEvent.mouseUp(window, {
+      clientX: -1000,
+      clientY: -1000,
+      button: 0,
+    });
+
+    // Should still clean up properly
+    expect(hasBlockEventsClass()).toBe(false);
+  });
+});
diff --git a/packages/grid/src/Grid.tsx b/packages/grid/src/Grid.tsx
index 92e741b9aa..1ef28b8d04 100644
--- a/packages/grid/src/Grid.tsx
+++ b/packages/grid/src/Grid.tsx
@@ -353,6 +353,10 @@ class Grid extends PureComponent<GridProps, GridState> {
   // blocked pointer events that would otherwise prevent cursor styling from showing
   documentCursor: string | null;
 
+  // Track if this Grid instance added the grid-block-events class
+  // Used to ensure only the Grid that added the class removes it
+  hasAddedBlockEvents: boolean;
+
   dragTimer: ReturnType<typeof setTimeout> | null;
 
   keyHandlers: readonly KeyHandler[];
@@ -410,6 +414,7 @@ class Grid extends PureComponent<GridProps, GridState> {
     // Note: on document, not body so that cursor styling can be combined with
     // blocked pointer events that would otherwise prevent cursor styling from showing
     this.documentCursor = null;
+    this.hasAddedBlockEvents = false;
 
     this.dragTimer = null;
 
@@ -1703,14 +1708,20 @@ class Grid extends PureComponent<GridProps, GridState> {
       document.documentElement.classList.add(this.documentCursor);
     }
     document.documentElement.classList.add('grid-block-events');
+    this.hasAddedBlockEvents = true;
   }
 
   removeDocumentCursor(): void {
     if (this.documentCursor != null) {
       document.documentElement.classList.remove(this.documentCursor);
-      document.documentElement.classList.remove('grid-block-events');
       this.documentCursor = null;
     }
+    // Only remove grid-block-events if this Grid instance added it
+    // This prevents one Grid from removing the class on unmount while another Grid is still dragging
+    if (this.hasAddedBlockEvents) {
+      document.documentElement.classList.remove('grid-block-events');
+      this.hasAddedBlockEvents = false;
+    }
   }
 
   startDragTimer(event: React.MouseEvent): void {
@@ -1918,24 +1929,23 @@ class Grid extends PureComponent<GridProps, GridState> {
   }
 
   handleMouseUp(event: MouseEvent): void {
-    // Ignore right click while dragging
+    // Ignore non-left click while dragging to allow drag to continue
     const { isDragging } = this.state;
-    if (isDragging && event.button === 2) {
+    if (isDragging && event.button !== 0) {
       return;
     }
 
     window.removeEventListener('mousemove', this.handleMouseDrag, true);
     window.removeEventListener('mouseup', this.handleMouseUp, true);
 
+    this.stopDragTimer();
+    this.removeDocumentCursor();
+
     if (event.button != null && event.button !== 0) {
       return;
     }
 
     this.notifyMouseHandlers('onUp', event, false);
-
-    this.stopDragTimer();
-
-    this.removeDocumentCursor();
   }
 
   handleResize(): void {