diff --git a/deepnote_toolkit/runtime_initialization.py b/deepnote_toolkit/runtime_initialization.py
index d8a7e3c..bfafaf5 100644
--- a/deepnote_toolkit/runtime_initialization.py
+++ b/deepnote_toolkit/runtime_initialization.py
@@ -6,6 +6,8 @@
 import psycopg2.extensions
 import psycopg2.extras
 
+from deepnote_toolkit.runtime_patches import apply_runtime_patches
+
 from .dataframe_utils import add_formatters
 from .execute_post_start_hooks import execute_post_start_hooks
 from .logging import LoggerManager
@@ -24,6 +26,11 @@ def init_deepnote_runtime():
 
     logger.debug("Initializing Deepnote runtime environment started.")
 
+    try:
+        apply_runtime_patches()
+    except Exception as e:
+        logger.error("Failed to apply runtime patches with a error: %s", e)
+
     # Register sparksql magic
     try:
         IPython.get_ipython().register_magics(SparkSql)
diff --git a/deepnote_toolkit/runtime_patches.py b/deepnote_toolkit/runtime_patches.py
new file mode 100644
index 0000000..9dda657
--- /dev/null
+++ b/deepnote_toolkit/runtime_patches.py
@@ -0,0 +1,53 @@
+from typing import Any, Optional, Union
+
+from deepnote_toolkit.logging import LoggerManager
+
+logger = LoggerManager().get_logger()
+
+
+# TODO(BLU-5171): Temporary hack to allow cancelling BigQuery jobs on KeyboardInterrupt (e.g. when user cancels cell execution)
+# Can be removed once
+# 1. https://github.com/googleapis/python-bigquery/pull/2331 is merged and released
+# 2. Dependencies updated for the toolkit. We don't depend on google-cloud-bigquery directly, but it's transitive
+# dependency through sqlalchemy-bigquery
+def _monkeypatch_bigquery_wait_or_cancel():
+    try:
+        import google.cloud.bigquery._job_helpers as _job_helpers
+        from google.cloud.bigquery import job, table
+
+        def _wait_or_cancel(
+            job_obj: job.QueryJob,
+            api_timeout: Optional[float],
+            wait_timeout: Optional[Union[object, float]],
+            retry: Optional[Any],
+            page_size: Optional[int],
+            max_results: Optional[int],
+        ) -> table.RowIterator:
+            try:
+                return job_obj.result(
+                    page_size=page_size,
+                    max_results=max_results,
+                    retry=retry,
+                    timeout=wait_timeout,
+                )
+            except (KeyboardInterrupt, Exception):
+                try:
+                    job_obj.cancel(retry=retry, timeout=api_timeout)
+                except (KeyboardInterrupt, Exception):
+                    pass
+                raise
+
+        _job_helpers._wait_or_cancel = _wait_or_cancel
+        logger.debug(
+            "Successfully monkeypatched google.cloud.bigquery._job_helpers._wait_or_cancel"
+        )
+    except ImportError:
+        logger.warning(
+            "Could not monkeypatch BigQuery _wait_or_cancel: google.cloud.bigquery not available"
+        )
+    except Exception as e:
+        logger.warning("Failed to monkeypatch BigQuery _wait_or_cancel: %s", repr(e))
+
+
+def apply_runtime_patches():
+    _monkeypatch_bigquery_wait_or_cancel()
diff --git a/tests/unit/conftest.py b/tests/unit/conftest.py
index a871dd8..5f9179d 100644
--- a/tests/unit/conftest.py
+++ b/tests/unit/conftest.py
@@ -7,6 +7,14 @@
 import pytest
 
 
+@pytest.fixture(autouse=True, scope="session")
+def apply_patches() -> None:
+    """Apply runtime patches once before any tests run."""
+    from deepnote_toolkit.runtime_patches import apply_runtime_patches
+
+    apply_runtime_patches()
+
+
 @pytest.fixture(autouse=True)
 def clean_runtime_state() -> Generator[None, None, None]:
     """Automatically clean in-memory env state and config cache before and after each test."""
diff --git a/tests/unit/test_sql_execution_internal.py b/tests/unit/test_sql_execution_internal.py
index 9e0187c..05eecf0 100644
--- a/tests/unit/test_sql_execution_internal.py
+++ b/tests/unit/test_sql_execution_internal.py
@@ -9,6 +9,27 @@
 from deepnote_toolkit.sql import sql_execution as se
 
 
+def test_bigquery_wait_or_cancel_handles_keyboard_interrupt():
+    import google.cloud.bigquery._job_helpers as _job_helpers
+
+    mock_job = mock.Mock()
+    mock_job.result.side_effect = KeyboardInterrupt("User interrupted")
+    mock_job.cancel = mock.Mock()
+
+    with pytest.raises(KeyboardInterrupt):
+        # _wait_or_cancel should be monkeypatched by `_monkeypatch_bigquery_wait_or_cancel`
+        _job_helpers._wait_or_cancel(
+            job_obj=mock_job,
+            api_timeout=30.0,
+            wait_timeout=60.0,
+            retry=None,
+            page_size=None,
+            max_results=None,
+        )
+
+    mock_job.cancel.assert_called_once_with(retry=None, timeout=30.0)
+
+
 def test_build_params_for_bigquery_oauth_ok():
     with mock.patch(
         "deepnote_toolkit.sql.sql_execution.bigquery.Client"