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I performance tests on my system, I got a faster program using linear search (e.g. clj-6, clj-7) versus binary search (clj-1 through clj-5) for looking up the gene characters in the cumulative distribution function. With the binary search a macro was a little faster than a function call, but linear search right inside of fill-random! beat them both. I also got a little faster results using byte-based output (clj-6) rather than char/String-based output (clj-1 through clj-5, and clj-7).