diff --git a/asgiref/sync.py b/asgiref/sync.py
index a46f7d4c..476604ad 100644
--- a/asgiref/sync.py
+++ b/asgiref/sync.py
@@ -61,9 +61,17 @@ def __init__(self, awaitable, force_new_loop=False):
             except RuntimeError:
                 # There's no event loop in this thread. Look for the threadlocal if
                 # we're inside SyncToAsync
-                self.main_event_loop = getattr(
-                    SyncToAsync.threadlocal, "main_event_loop", None
+                main_event_loop_pid = getattr(
+                    SyncToAsync.threadlocal, "main_event_loop_pid", None
                 )
+                # We make sure the parent loop is from the same process - if
+                # they've forked, this is not going to be valid any more (#194)
+                if main_event_loop_pid and main_event_loop_pid == os.getpid():
+                    self.main_event_loop = getattr(
+                        SyncToAsync.threadlocal, "main_event_loop", None
+                    )
+                else:
+                    self.main_event_loop = None
 
     def __call__(self, *args, **kwargs):
         # You can't call AsyncToSync from a thread with a running event loop
@@ -312,6 +320,7 @@ def thread_handler(self, loop, source_task, exc_info, func, *args, **kwargs):
         """
         # Set the threadlocal for AsyncToSync
         self.threadlocal.main_event_loop = loop
+        self.threadlocal.main_event_loop_pid = os.getpid()
         # Set the task mapping (used for the locals module)
         current_thread = threading.current_thread()
         if AsyncToSync.launch_map.get(source_task) == current_thread:
diff --git a/tests/test_sync.py b/tests/test_sync.py
index 5a4b3423..b6ebd595 100644
--- a/tests/test_sync.py
+++ b/tests/test_sync.py
@@ -1,6 +1,7 @@
 import asyncio
 import threading
 import time
+import multiprocessing
 from concurrent.futures import ThreadPoolExecutor
 from functools import wraps
 from unittest import TestCase
@@ -415,3 +416,32 @@ def sync_func():
 
     assert not asyncio.iscoroutinefunction(sync_to_async)
     assert asyncio.iscoroutinefunction(sync_to_async(sync_func))
+
+
+@pytest.mark.asyncio
+async def test_multiprocessing():
+    """
+    Tests that a forked process can use async_to_sync without it looking for
+    the event loop from the parent process.
+    """
+
+    test_queue = multiprocessing.Queue()
+
+    async def async_process():
+        test_queue.put(42)
+
+    def sync_process():
+        """Runs async_process synchronously"""
+        async_to_sync(async_process)()
+
+    def fork_first():
+        """Forks process before running sync_process"""
+        fork = multiprocessing.Process(target=sync_process)
+        fork.start()
+        fork.join(3)
+        # Force cleanup in failed test case
+        if fork.is_alive():
+            fork.terminate()
+        return test_queue.get(True, 1)
+
+    assert await sync_to_async(fork_first)() == 42