diff --git a/django/conf/global_settings.py b/django/conf/global_settings.py
index 11b1c0e08a471..5b3795fade2b7 100644
--- a/django/conf/global_settings.py
+++ b/django/conf/global_settings.py
@@ -223,10 +223,6 @@
 # http://www.djangoproject.com/documentation/templates/#now
 MONTH_DAY_FORMAT = 'F j'
 
-# Whether to enable Psyco, which optimizes Python code. Requires Psyco.
-# http://psyco.sourceforge.net/
-ENABLE_PSYCO = False
-
 # Do you want to manage transactions manually?
 # Hint: you really don't!
 TRANSACTIONS_MANAGED = False
diff --git a/django/core/handlers/modpython.py b/django/core/handlers/modpython.py
index d7f214ba90f93..bf759db06815e 100644
--- a/django/core/handlers/modpython.py
+++ b/django/core/handlers/modpython.py
@@ -139,10 +139,6 @@ def __call__(self, req):
         # that use settings now can work
         from django.conf import settings
 
-        if settings.ENABLE_PSYCO:
-            import psyco
-            psyco.profile()
-
         # if we need to set up middleware, now that settings works we can do it now.
         if self._request_middleware is None:
             self.load_middleware()
diff --git a/django/core/handlers/wsgi.py b/django/core/handlers/wsgi.py
index 4d5c65b0703ec..2998bd31f6d93 100644
--- a/django/core/handlers/wsgi.py
+++ b/django/core/handlers/wsgi.py
@@ -174,10 +174,6 @@ class WSGIHandler(BaseHandler):
     def __call__(self, environ, start_response):
         from django.conf import settings
 
-        if settings.ENABLE_PSYCO:
-            import psyco
-            psyco.profile()
-
         # Set up middleware if needed. We couldn't do this earlier, because
         # settings weren't available.
         if self._request_middleware is None:
diff --git a/docs/settings.txt b/docs/settings.txt
index 61355c46ada6d..0e808c018b883 100644
--- a/docs/settings.txt
+++ b/docs/settings.txt
@@ -401,15 +401,6 @@ Subject-line prefix for e-mail messages sent with ``django.core.mail.mail_admins
 or ``django.core.mail.mail_managers``. You'll probably want to include the
 trailing space.
 
-ENABLE_PSYCO
-------------
-
-Default: ``False``
-
-Whether to enable Psyco, which optimizes Python code. Requires Psyco_.
-
-.. _Psyco: http://psyco.sourceforge.net/
-
 IGNORABLE_404_ENDS
 ------------------