diff --git a/src/declaration.d b/src/declaration.d
index feb3b0eb5323..0be3e05dd334 100644
--- a/src/declaration.d
+++ b/src/declaration.d
@@ -1949,39 +1949,44 @@ extern (C++) class VarDeclaration : Declaration
             _init = _init.semantic(sc, type, sc.intypeof == 1 ? INITnointerpret : INITinterpret);
             inuse--;
         }
-        if (storage_class & STCmanifest)
+        if (_init && storage_class & STCmanifest)
         {
-            version (none)
+            /* Cannot initializer enums with CTFE classreferences and addresses of struct literals.
+             * Scan initializer looking for them. Issue error if found.
+             */
+            if (ExpInitializer ei = _init.isExpInitializer())
             {
-                if ((type.ty == Tclass) && type.isMutable())
+                static bool hasInvalidEnumInitializer(Expression e)
                 {
-                    error("is mutable. Only const and immutable class enum are allowed, not %s", type.toChars());
-                }
-                else if (type.ty == Tpointer && type.nextOf().ty == Tstruct && type.nextOf().isMutable())
-                {
-                    ExpInitializer ei = _init.isExpInitializer();
-                    if (ei.exp.op == TOKaddress && (cast(AddrExp)ei.exp).e1.op == TOKstructliteral)
+                    static bool arrayHasInvalidEnumInitializer(Expressions* elems)
                     {
-                        error("is a pointer to mutable struct. Only pointers to const or immutable struct enum are allowed, not %s", type.toChars());
+                        foreach (e; *elems)
+                        {
+                            if (e && hasInvalidEnumInitializer(e))
+                                return true;
+                        }
+                        return false;
                     }
-                }
-            }
-            else
-            {
-                if (type.ty == Tclass && _init)
-                {
-                    ExpInitializer ei = _init.isExpInitializer();
-                    if (ei.exp.op == TOKclassreference)
-                        error(": Unable to initialize enum with class or pointer to struct. Use static const variable instead.");
-                }
-                else if (type.ty == Tpointer && type.nextOf().ty == Tstruct)
-                {
-                    ExpInitializer ei = _init.isExpInitializer();
-                    if (ei && ei.exp.op == TOKaddress && (cast(AddrExp)ei.exp).e1.op == TOKstructliteral)
+
+                    if (e.op == TOKclassreference)
+                        return true;
+                    if (e.op == TOKaddress && (cast(AddrExp)e).e1.op == TOKstructliteral)
+                        return true;
+                    if (e.op == TOKarrayliteral)
+                        return arrayHasInvalidEnumInitializer((cast(ArrayLiteralExp)e).elements);
+                    if (e.op == TOKstructliteral)
+                        return arrayHasInvalidEnumInitializer((cast(StructLiteralExp)e).elements);
+                    if (e.op == TOKassocarrayliteral)
                     {
-                        error(": Unable to initialize enum with class or pointer to struct. Use static const variable instead.");
+                        AssocArrayLiteralExp ae = cast(AssocArrayLiteralExp)e;
+                        return arrayHasInvalidEnumInitializer(ae.values) ||
+                               arrayHasInvalidEnumInitializer(ae.keys);
                     }
+                    return false;
                 }
+
+                if (hasInvalidEnumInitializer(ei.exp))
+                    error(": Unable to initialize enum with class or pointer to struct. Use static const variable instead.");
             }
         }
         else if (_init && isThreadlocal())
diff --git a/test/compilable/interpret3.d b/test/compilable/interpret3.d
index a4b6da798c96..9340241cf477 100644
--- a/test/compilable/interpret3.d
+++ b/test/compilable/interpret3.d
@@ -2692,11 +2692,6 @@ enum arr12528V2 = dup12528([0, 1]);
 static assert(arr12528V1 == [0]);
 static assert(arr12528V2 == [0, 1]);
 
-enum arr12528C1 = dup12528([new immutable Object]);
-enum arr12528C2 = dup12528([new immutable Object, new immutable Object]);
-static assert(arr12528C1.length == 1);
-static assert(arr12528C2.length == 2 && arr12528C2[0] !is arr12528C2[1]);
-
 /**************************************************
     9745 Allow pointers to static variables
 **************************************************/
diff --git a/test/fail_compilation/test15989.d b/test/fail_compilation/test15989.d
new file mode 100644
index 000000000000..29eab9c38cbd
--- /dev/null
+++ b/test/fail_compilation/test15989.d
@@ -0,0 +1,52 @@
+/*
+PERMUTE_ARGS:
+TEST_OUTPUT:
+---
+fail_compilation/test15989.d(40): Error: variable test15989.main.ctRegex : Unable to initialize enum with class or pointer to struct. Use static const variable instead.
+fail_compilation/test15989.d(49): Error: variable test15989.test.c : Unable to initialize enum with class or pointer to struct. Use static const variable instead.
+fail_compilation/test15989.d(50): Error: cannot use non-constant CTFE pointer in an initializer '&[3][0]'
+---
+*/
+
+// https://issues.dlang.org/show_bug.cgi?id=15989
+
+import core.stdc.stdio;
+
+interface Kickstart{
+    bool foo( int );
+}
+
+class ShiftOr : Kickstart
+{
+    bool foo( int i )
+    {
+        printf("i = %d\n", i);
+        return false;
+    }
+}
+
+struct Regex
+{
+    Kickstart kickstart;
+}
+
+Regex regex()
+{
+    return Regex(new ShiftOr());
+}
+
+void main()
+{
+    enum ctRegex = regex();
+    Regex r = ctRegex;
+    r.kickstart.foo(7);
+}
+
+class C { }
+
+void test()
+{
+    enum c = new C();
+    enum pi = new int(3);
+}
+