diff --git a/Source/Core/VideoBackends/OGL/ProgramShaderCache.cpp b/Source/Core/VideoBackends/OGL/ProgramShaderCache.cpp
index f4e7dcb6a781..e81c6d2d8434 100644
--- a/Source/Core/VideoBackends/OGL/ProgramShaderCache.cpp
+++ b/Source/Core/VideoBackends/OGL/ProgramShaderCache.cpp
@@ -96,7 +96,7 @@ void SHADER::SetProgramVariables()
 	Bind();
 
 	// Bind UBO
-	if (g_ActiveConfig.backend_info.bSupportsGLSLUBO)
+	if (g_ActiveConfig.backend_info.bSupportsGLSLUBO && !g_ActiveConfig.backend_info.bSupportShadingLanguage420pack)
 	{
 		GLint PSBlock_id = glGetUniformBlockIndex(glprogid, "PSBlock");
 		GLint VSBlock_id = glGetUniformBlockIndex(glprogid, "VSBlock");
@@ -135,7 +135,6 @@ void SHADER::SetProgramVariables()
 		}
 	}
 
-
 	// Bind Texture Sampler
 	for (int a = 0; a <= 9; ++a)
 	{
@@ -569,6 +568,7 @@ void ProgramShaderCache::CreateHeader ( void )
 		"%s\n"
 		"%s\n" // ubo
 		"%s\n" // early-z
+		"%s\n" // 420pack
 
 		// Precision defines for GLSLES3
 		"%s\n"
@@ -597,6 +597,7 @@ void ProgramShaderCache::CreateHeader ( void )
 		, v==GLSLES3 ? "#version 300 es" : v==GLSL_130 ? "#version 130" : v==GLSL_140 ? "#version 140" : "#version 150"
 		, g_ActiveConfig.backend_info.bSupportsGLSLUBO && v<GLSL_140 ? "#extension GL_ARB_uniform_buffer_object : enable" : ""
 		, g_ActiveConfig.backend_info.bSupportsEarlyZ ? "#extension GL_ARB_shader_image_load_store : enable" : ""
+		, g_ActiveConfig.backend_info.bSupportShadingLanguage420pack ? "#extension GL_ARB_shading_language_420pack : enable" : ""
 
 		, v==GLSLES3 ? "precision highp float;" : ""
 
diff --git a/Source/Core/VideoBackends/OGL/Render.cpp b/Source/Core/VideoBackends/OGL/Render.cpp
index 2013fa5c5532..ea84b509d906 100644
--- a/Source/Core/VideoBackends/OGL/Render.cpp
+++ b/Source/Core/VideoBackends/OGL/Render.cpp
@@ -371,6 +371,7 @@ Renderer::Renderer()
 	g_Config.backend_info.bSupportsGLSLUBO = !DriverDetails::HasBug(DriverDetails::BUG_ANNIHILATEDUBOS);
 	g_Config.backend_info.bSupportsPrimitiveRestart = true;
 	g_Config.backend_info.bSupportsEarlyZ = false;
+	g_Config.backend_info.bSupportShadingLanguage420pack = false;
 
 	g_ogl_config.bSupportsGLSLCache = true;
 	g_ogl_config.bSupportsGLPinnedMemory = false;
@@ -482,6 +483,7 @@ Renderer::Renderer()
 	g_Config.backend_info.bSupportsPrimitiveRestart = !DriverDetails::HasBug(DriverDetails::BUG_PRIMITIVERESTART) && 
 				(TO_BOOL(GLEW_VERSION_3_1) || TO_BOOL(GLEW_NV_primitive_restart));
 	g_Config.backend_info.bSupportsEarlyZ = TO_BOOL(GLEW_ARB_shader_image_load_store);
+	g_Config.backend_info.bSupportShadingLanguage420pack = TO_BOOL(GLEW_ARB_shading_language_420pack);
 
 	g_ogl_config.bSupportsGLSLCache = TO_BOOL(GLEW_ARB_get_program_binary);
 	g_ogl_config.bSupportsGLPinnedMemory = TO_BOOL(GLEW_AMD_pinned_memory);
diff --git a/Source/Core/VideoCommon/PixelShaderGen.cpp b/Source/Core/VideoCommon/PixelShaderGen.cpp
index 26e5cc0eba41..db8c8bdd6b0c 100644
--- a/Source/Core/VideoCommon/PixelShaderGen.cpp
+++ b/Source/Core/VideoCommon/PixelShaderGen.cpp
@@ -284,7 +284,7 @@ static inline void GeneratePixelShader(T& out, DSTALPHA_MODE dstAlphaMode, API_T
 	out.Write("\n");
 
 	if (g_ActiveConfig.backend_info.bSupportsGLSLUBO)
-		out.Write("layout(std140) uniform PSBlock {\n");
+		out.Write("layout(std140%s) uniform PSBlock {\n", g_ActiveConfig.backend_info.bSupportShadingLanguage420pack ? ", binding = 1" : "");
 
 	DeclareUniform(out, ApiType, g_ActiveConfig.backend_info.bSupportsGLSLUBO, C_COLORS, "float4", I_COLORS"[4]");
 	DeclareUniform(out, ApiType, g_ActiveConfig.backend_info.bSupportsGLSLUBO, C_KCOLORS, "float4", I_KCOLORS"[4]");
diff --git a/Source/Core/VideoCommon/VertexShaderGen.cpp b/Source/Core/VideoCommon/VertexShaderGen.cpp
index f0cce5d7500b..9ff8617976d1 100644
--- a/Source/Core/VideoCommon/VertexShaderGen.cpp
+++ b/Source/Core/VideoCommon/VertexShaderGen.cpp
@@ -84,7 +84,7 @@ static inline void GenerateVertexShader(T& out, u32 components, API_TYPE api_typ
 
 	// uniforms
 	if (g_ActiveConfig.backend_info.bSupportsGLSLUBO)
-		out.Write("layout(std140) uniform VSBlock {\n");
+		out.Write("layout(std140%s) uniform VSBlock {\n", g_ActiveConfig.backend_info.bSupportShadingLanguage420pack ? ", binding = 2" : "");
 
 	DeclareUniform(out, api_type, g_ActiveConfig.backend_info.bSupportsGLSLUBO, C_POSNORMALMATRIX, "float4", I_POSNORMALMATRIX"[6]");
 	DeclareUniform(out, api_type, g_ActiveConfig.backend_info.bSupportsGLSLUBO, C_PROJECTION, "float4", I_PROJECTION"[4]");
diff --git a/Source/Core/VideoCommon/VideoConfig.h b/Source/Core/VideoCommon/VideoConfig.h
index f53551d9a036..71d0b7f22cae 100644
--- a/Source/Core/VideoCommon/VideoConfig.h
+++ b/Source/Core/VideoCommon/VideoConfig.h
@@ -155,6 +155,7 @@ struct VideoConfig
 		bool bSupportsOversizedViewports;
 		bool bSupportsGLSLUBO; // needed by PixelShaderGen, so must stay in VideoCommon
 		bool bSupportsEarlyZ; // needed by PixelShaderGen, so must stay in VideoCommon
+		bool bSupportShadingLanguage420pack; // needed by ShaderGen, so must stay in VideoCommon
 	} backend_info;
 
 	// Utility