diff --git a/src/jit/importer.cpp b/src/jit/importer.cpp
index 64c6f4563850..d47e3dfb97db 100644
--- a/src/jit/importer.cpp
+++ b/src/jit/importer.cpp
@@ -10094,7 +10094,11 @@ void Compiler::impImportBlockCode(BasicBlock* block)
                     const bool isSingleILStoreLocal =
                         !lvaTable[lclNum].lvHasMultipleILStoreOp && !lvaTable[lclNum].lvHasLdAddrOp;
 
-                    if (isSingleILStoreLocal)
+                    // Conservative check that there is just one
+                    // definition that reaches this store.
+                    const bool hasSingleReachingDef = (block->bbStackDepthOnEntry() == 0);
+
+                    if (isSingleILStoreLocal && hasSingleReachingDef)
                     {
                         lvaUpdateClass(lclNum, op1, clsHnd);
                     }
diff --git a/tests/src/JIT/opt/Devirtualization/GitHub_10858.cs b/tests/src/JIT/opt/Devirtualization/GitHub_10858.cs
new file mode 100644
index 000000000000..a02d025593c6
--- /dev/null
+++ b/tests/src/JIT/opt/Devirtualization/GitHub_10858.cs
@@ -0,0 +1,46 @@
+// Licensed to the .NET Foundation under one or more agreements.
+// The .NET Foundation licenses this file to you under the MIT license.
+// See the LICENSE file in the project root for more information.
+
+using System;
+
+class B 
+{
+    public virtual string F() { return "B"; }
+}
+
+sealed class D : B
+{
+    public override string F() { return "D"; }
+}
+
+sealed class E : B
+{
+    public override string F() { return "E"; }
+}
+
+class X
+{
+    public static int Main(string[] args)
+    {
+        // When optimizing IL, CSC will leave the newobj's on the stack
+        // across the branches to the common def point.
+        B b1 = (args.Length > 0) ? (B)new E() : (B)new D();
+        B b2 = null;
+
+        // Conditional flow here to forces b1 to a local instead of
+        // remaining on the stack. So we have a single def point with
+        // two reaching values.
+        if (args.Length > 0)
+        {
+            b2 = new D();
+        }
+        else
+        {
+            b2 = new E();
+        }
+
+        // We should not be able to devirtualize either call.
+        return b2.F()[0] + b1.F()[0] - 37;
+    }
+}
diff --git a/tests/src/JIT/opt/Devirtualization/GitHub_10858.csproj b/tests/src/JIT/opt/Devirtualization/GitHub_10858.csproj
new file mode 100644
index 000000000000..fdf04a29e00e
--- /dev/null
+++ b/tests/src/JIT/opt/Devirtualization/GitHub_10858.csproj
@@ -0,0 +1,37 @@
+<?xml version="1.0" encoding="utf-8"?>
+<Project ToolsVersion="12.0" DefaultTargets="Build" xmlns="http://schemas.microsoft.com/developer/msbuild/2003">
+  <Import Project="$([MSBuild]::GetDirectoryNameOfFileAbove($(MSBuildThisFileDirectory), dir.props))\dir.props" />
+  <PropertyGroup>
+    <Configuration Condition=" '$(Configuration)' == '' ">Debug</Configuration>
+    <Platform Condition=" '$(Platform)' == '' ">AnyCPU</Platform>
+    <AssemblyName>$(MSBuildProjectName)</AssemblyName>
+    <SchemaVersion>2.0</SchemaVersion>
+    <ProjectGuid>{95DFC527-4DC1-495E-97D7-E94EE1F7140D}</ProjectGuid>
+    <OutputType>Exe</OutputType>
+    <ProjectTypeGuids>{786C830F-07A1-408B-BD7F-6EE04809D6DB};{FAE04EC0-301F-11D3-BF4B-00C04F79EFBC}</ProjectTypeGuids>
+    <SolutionDir Condition="$(SolutionDir) == '' Or $(SolutionDir) == '*Undefined*'">..\..\</SolutionDir>
+  </PropertyGroup>
+  <!-- Default configurations to help VS understand the configurations -->
+  <PropertyGroup Condition=" '$(Configuration)|$(Platform)' == 'Debug|AnyCPU' ">
+  </PropertyGroup>
+  <PropertyGroup Condition=" '$(Configuration)|$(Platform)' == 'Release|AnyCPU' ">
+  </PropertyGroup>
+  <ItemGroup>
+    <CodeAnalysisDependentAssemblyPaths Condition=" '$(VS100COMNTOOLS)' != '' " Include="$(VS100COMNTOOLS)..\IDE\PrivateAssemblies">
+      <Visible>False</Visible>
+    </CodeAnalysisDependentAssemblyPaths>
+  </ItemGroup>
+  <PropertyGroup>
+    <DebugType>None</DebugType>
+    <Optimize>True</Optimize>
+  </PropertyGroup>
+  <ItemGroup>
+    <Compile Include="GitHub_10858.cs" />
+  </ItemGroup>
+  <ItemGroup>
+    <Service Include="{82A7F48D-3B50-4B1E-B82E-3ADA8210C358}" />
+  </ItemGroup>
+  <Import Project="$([MSBuild]::GetDirectoryNameOfFileAbove($(MSBuildThisFileDirectory), dir.targets))\dir.targets" />
+  <PropertyGroup Condition=" '$(MsBuildProjectDirOverride)' != '' ">
+  </PropertyGroup>
+</Project>