diff --git a/eng/pipelines/extra-platforms/runtime-extra-platforms-wasm.yml b/eng/pipelines/extra-platforms/runtime-extra-platforms-wasm.yml
index 32899b04862407..1ae95a62c6b8ec 100644
--- a/eng/pipelines/extra-platforms/runtime-extra-platforms-wasm.yml
+++ b/eng/pipelines/extra-platforms/runtime-extra-platforms-wasm.yml
@@ -32,16 +32,17 @@ jobs:
       alwaysRun: true
 
   # AOT Library tests - wasi_wasm
-  - template: /eng/pipelines/common/templates/wasm-library-aot-tests.yml
-    parameters:
-      platforms:
-        - wasi_wasm
-        - wasi_wasm_win
-      nameSuffix: _AOT
-      extraBuildArgs: /p:AotHostArchitecture=x64 /p:AotHostOS=$(_hostedOS)
-      runAOT: true
-      alwaysRun: true
-      shouldContinueOnError: true
+  # Disabled: https://github.com/dotnet/runtime/issues/128772
+  # - template: /eng/pipelines/common/templates/wasm-library-aot-tests.yml
+  #   parameters:
+  #     platforms:
+  #       - wasi_wasm
+  #       - wasi_wasm_win
+  #     nameSuffix: _AOT
+  #     extraBuildArgs: /p:AotHostArchitecture=x64 /p:AotHostOS=$(_hostedOS)
+  #     runAOT: true
+  #     alwaysRun: true
+  #     shouldContinueOnError: true
 
   # High resource AOT Library tests
   - template: /eng/pipelines/common/templates/wasm-library-aot-tests.yml
@@ -106,18 +107,19 @@ jobs:
       alwaysRun: ${{ parameters.isWasmOnlyBuild }}
 
   # AOT Library tests - wasi_wasm
-  - template: /eng/pipelines/common/templates/wasm-library-aot-tests.yml
-    parameters:
-      platforms:
-        - wasi_wasm
-        - wasi_wasm_win
-      nameSuffix: _AOT
-      extraBuildArgs: /p:AotHostArchitecture=x64 /p:AotHostOS=$(_hostedOS)
-      runAOT: true
-      shouldContinueOnError: true
-      isExtraPlatformsBuild: ${{ parameters.isExtraPlatformsBuild }}
-      isWasmOnlyBuild: ${{ parameters.isWasmOnlyBuild }}
-      alwaysRun: ${{ parameters.isWasmOnlyBuild }}
+  # Disabled: https://github.com/dotnet/runtime/issues/128772
+  # - template: /eng/pipelines/common/templates/wasm-library-aot-tests.yml
+  #   parameters:
+  #     platforms:
+  #       - wasi_wasm
+  #       - wasi_wasm_win
+  #     nameSuffix: _AOT
+  #     extraBuildArgs: /p:AotHostArchitecture=x64 /p:AotHostOS=$(_hostedOS)
+  #     runAOT: true
+  #     shouldContinueOnError: true
+  #     isExtraPlatformsBuild: ${{ parameters.isExtraPlatformsBuild }}
+  #     isWasmOnlyBuild: ${{ parameters.isWasmOnlyBuild }}
+  #     alwaysRun: ${{ parameters.isWasmOnlyBuild }}
 
   # High resource AOT Library tests
   - template: /eng/pipelines/common/templates/wasm-library-aot-tests.yml
@@ -134,20 +136,21 @@ jobs:
       alwaysRun: ${{ parameters.isWasmOnlyBuild }}
 
   # Wasi - run only smoke tests by default
-  - template: /eng/pipelines/common/templates/wasm-library-tests.yml
-    parameters:
-      platforms:
-        - wasi_wasm
-        - wasi_wasm_win
-      nameSuffix: '_Smoke'
-      extraBuildArgs: /p:EnableAggressiveTrimming=true /p:RunWasmSamples=true /p:AotHostArchitecture=x64 /p:AotHostOS=$(_hostedOS)
-      shouldRunSmokeOnly: true
-      # ignore test failures for runtime-extra-platforms, but not when this
-      # is run as part of a wasm specific pipeline like runtime-wasm
-      shouldContinueOnError: ${{ not(parameters.isWasmOnlyBuild) }}
-      alwaysRun: ${{ variables.isRollingBuild }}
-      scenarios:
-        - WasmTestOnWasmtime
+  # Disabled: https://github.com/dotnet/runtime/issues/128772
+  # - template: /eng/pipelines/common/templates/wasm-library-tests.yml
+  #   parameters:
+  #     platforms:
+  #       - wasi_wasm
+  #       - wasi_wasm_win
+  #     nameSuffix: '_Smoke'
+  #     extraBuildArgs: /p:EnableAggressiveTrimming=true /p:RunWasmSamples=true /p:AotHostArchitecture=x64 /p:AotHostOS=$(_hostedOS)
+  #     shouldRunSmokeOnly: true
+  #     # ignore test failures for runtime-extra-platforms, but not when this
+  #     # is run as part of a wasm specific pipeline like runtime-wasm
+  #     shouldContinueOnError: ${{ not(parameters.isWasmOnlyBuild) }}
+  #     alwaysRun: ${{ variables.isRollingBuild }}
+  #     scenarios:
+  #       - WasmTestOnWasmtime
 
   # Hybrid Globalization tests
   - template: /eng/pipelines/common/templates/wasm-library-tests.yml
@@ -212,14 +215,15 @@ jobs:
         - browser_wasm_win
       extraBuildArgs: /p:AotHostArchitecture=x64 /p:AotHostOS=$(_hostedOS)
 
-  - template: /eng/pipelines/common/templates/simple-wasm-build-tests.yml
-    parameters:
-      platforms:
-        - wasi_wasm
-        - wasi_wasm_win
-      extraBuildArgs: /p:AotHostArchitecture=x64 /p:AotHostOS=$(_hostedOS)
-      isExtraPlatformsBuild: ${{ parameters.isExtraPlatformsBuild }}
-      isWasmOnlyBuild: ${{ parameters.isWasmOnlyBuild }}
+  # Disabled: https://github.com/dotnet/runtime/issues/128772
+  # - template: /eng/pipelines/common/templates/simple-wasm-build-tests.yml
+  #   parameters:
+  #     platforms:
+  #       - wasi_wasm
+  #       - wasi_wasm_win
+  #     extraBuildArgs: /p:AotHostArchitecture=x64 /p:AotHostOS=$(_hostedOS)
+  #     isExtraPlatformsBuild: ${{ parameters.isExtraPlatformsBuild }}
+  #     isWasmOnlyBuild: ${{ parameters.isWasmOnlyBuild }}
 
   - template: /eng/pipelines/common/templates/wasm-runtime-tests.yml
     parameters:
@@ -236,15 +240,16 @@ jobs:
       #onlySanityCheck: true
 
 - ${{ if and(ne(parameters.isRollingBuild, true), ne(parameters.excludeOptional, true)) }}:
-  - template: /eng/pipelines/common/templates/wasm-library-tests.yml
-    parameters:
-      platforms:
-        - wasi_wasm
-        - wasi_wasm_win
-      extraBuildArgs: /p:EnableAggressiveTrimming=true /p:RunWasmSamples=true /p:AotHostArchitecture=x64 /p:AotHostOS=$(_hostedOS)
-      # always run for wasm only pipelines
-      alwaysRun: ${{ parameters.isWasmOnlyBuild }}
-      isExtraPlatformsBuild: ${{ parameters.isExtraPlatformsBuild }}
-      isWasmOnlyBuild: ${{ parameters.isWasmOnlyBuild }}
-      scenarios:
-        - WasmTestOnWasmtime
+  # Disabled: https://github.com/dotnet/runtime/issues/128772
+  # - template: /eng/pipelines/common/templates/wasm-library-tests.yml
+  #   parameters:
+  #     platforms:
+  #       - wasi_wasm
+  #       - wasi_wasm_win
+  #     extraBuildArgs: /p:EnableAggressiveTrimming=true /p:RunWasmSamples=true /p:AotHostArchitecture=x64 /p:AotHostOS=$(_hostedOS)
+  #     # always run for wasm only pipelines
+  #     alwaysRun: ${{ parameters.isWasmOnlyBuild }}
+  #     isExtraPlatformsBuild: ${{ parameters.isExtraPlatformsBuild }}
+  #     isWasmOnlyBuild: ${{ parameters.isWasmOnlyBuild }}
+  #     scenarios:
+  #       - WasmTestOnWasmtime
diff --git a/eng/pipelines/runtime.yml b/eng/pipelines/runtime.yml
index f94bd937525cd6..1cf97ee70d02cb 100644
--- a/eng/pipelines/runtime.yml
+++ b/eng/pipelines/runtime.yml
@@ -738,7 +738,7 @@ extends:
           platforms:
           - android_x64
           - browser_wasm
-          - wasi_wasm
+          # - wasi_wasm
           - tvos_arm64
           - ios_arm64
           - maccatalyst_x64
@@ -1190,17 +1190,15 @@ extends:
           - linux_musl_arm64
           jobParameters:
             buildArgs: -s mono+packs -c $(_BuildConfig)
-                      /p:MonoCrossAOTTargetOS=android+browser+wasi /p:SkipMonoCrossJitConfigure=true /p:BuildMonoAOTCrossCompilerOnly=true
+                      /p:MonoCrossAOTTargetOS=android+browser /p:SkipMonoCrossJitConfigure=true /p:BuildMonoAOTCrossCompilerOnly=true
             nameSuffix: CrossAOT_Mono
             runtimeVariant: crossaot
             dependsOn:
             - build_android_x64_release_MonoAOTOffsets
             - build_browser_wasm_linux_release_MonoAOTOffsets
-            - build_wasi_wasm_linux_release_MonoAOTOffsets
             monoCrossAOTTargetOS:
             - android
             - browser
-            - wasi
             condition: >-
               or(
                 eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_mono_excluding_wasm.containsChange'], true),
@@ -1217,17 +1215,15 @@ extends:
           - windows_x64
           jobParameters:
             buildArgs: -s mono+packs -c $(_BuildConfig)
-                      /p:MonoCrossAOTTargetOS=android+browser+wasi /p:SkipMonoCrossJitConfigure=true /p:BuildMonoAOTCrossCompilerOnly=true
+                      /p:MonoCrossAOTTargetOS=android+browser /p:SkipMonoCrossJitConfigure=true /p:BuildMonoAOTCrossCompilerOnly=true
             nameSuffix: CrossAOT_Mono
             runtimeVariant: crossaot
             dependsOn:
             - build_android_x64_release_MonoAOTOffsets
             - build_browser_wasm_linux_release_MonoAOTOffsets
-            - build_wasi_wasm_linux_release_MonoAOTOffsets
             monoCrossAOTTargetOS:
             - android
             - browser
-            - wasi
             condition: >-
               or(
                 eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_mono_excluding_wasm.containsChange'], true),
@@ -1248,20 +1244,18 @@ extends:
           - osx_arm64
           jobParameters:
             buildArgs: -s mono+packs -c $(_BuildConfig)
-                      /p:MonoCrossAOTTargetOS=android+browser+wasi+tvos+ios+maccatalyst /p:SkipMonoCrossJitConfigure=true /p:BuildMonoAOTCrossCompilerOnly=true
+                      /p:MonoCrossAOTTargetOS=android+browser+tvos+ios+maccatalyst /p:SkipMonoCrossJitConfigure=true /p:BuildMonoAOTCrossCompilerOnly=true
             nameSuffix: CrossAOT_Mono
             runtimeVariant: crossaot
             dependsOn:
             - build_android_x64_release_MonoAOTOffsets
             - build_browser_wasm_linux_release_MonoAOTOffsets
-            - build_wasi_wasm_linux_release_MonoAOTOffsets
             - build_tvos_arm64_release_MonoAOTOffsets
             - build_ios_arm64_release_MonoAOTOffsets
             - build_maccatalyst_x64_release_MonoAOTOffsets
             monoCrossAOTTargetOS:
             - android
             - browser
-            - wasi
             - tvos
             - ios
             - maccatalyst