diff --git a/src/Assets/TestProjects/KitchenSink/TestApp/TestApp.csproj b/src/Assets/TestProjects/KitchenSink/TestApp/TestApp.csproj
index 07685dd9654f..22f4cdf84727 100644
--- a/src/Assets/TestProjects/KitchenSink/TestApp/TestApp.csproj
+++ b/src/Assets/TestProjects/KitchenSink/TestApp/TestApp.csproj
@@ -9,6 +9,8 @@
   <!-- Host configuration properties
        Keep this list in the same order as the configProperties in GivenThatWeWantToPublishAProjectWithAllFeatures. -->
   <PropertyGroup>
+    <VerifyDependencyInjectionOpenGenericServiceTrimmability>true</VerifyDependencyInjectionOpenGenericServiceTrimmability>
+    <_AggressiveAttributeTrimming>true</_AggressiveAttributeTrimming>
     <EnableUnsafeBinaryFormatterInDesigntimeLicenseContextSerialization>false</EnableUnsafeBinaryFormatterInDesigntimeLicenseContextSerialization>
     <DebuggerSupport>true</DebuggerSupport>
     <EventSourceSupport>false</EventSourceSupport>
@@ -20,6 +22,7 @@
     <HttpActivityPropagationSupport>false</HttpActivityPropagationSupport>
     <UseNativeHttpHandler>true</UseNativeHttpHandler>
     <MetadataUpdaterSupport>false</MetadataUpdaterSupport>
+    <NullabilityInfoContextSupport>false</NullabilityInfoContextSupport>
     <CustomResourceTypesSupport>false</CustomResourceTypesSupport>
     <UseSystemResourceKeys>true</UseSystemResourceKeys>
     <BuiltInComInteropSupport>false</BuiltInComInteropSupport>
diff --git a/src/BlazorWasmSdk/Targets/Microsoft.NET.Sdk.BlazorWebAssembly.6_0.targets b/src/BlazorWasmSdk/Targets/Microsoft.NET.Sdk.BlazorWebAssembly.6_0.targets
index 35e7038020ec..0a9bf97c6fbc 100644
--- a/src/BlazorWasmSdk/Targets/Microsoft.NET.Sdk.BlazorWebAssembly.6_0.targets
+++ b/src/BlazorWasmSdk/Targets/Microsoft.NET.Sdk.BlazorWebAssembly.6_0.targets
@@ -47,6 +47,8 @@ Copyright (c) .NET Foundation. All rights reserved.
     <UseSystemResourceKeys Condition="'$(UseSystemResourceKeys)' == ''">true</UseSystemResourceKeys>
     <EnableUnsafeUTF7Encoding Condition="'$(EnableUnsafeUTF7Encoding)' == ''">false</EnableUnsafeUTF7Encoding>
     <HttpActivityPropagationSupport Condition="'$(HttpActivityPropagationSupport)' == ''">false</HttpActivityPropagationSupport>
+    <NullabilityInfoContextSupport Condition="'$(NullabilityInfoContextSupport)' == ''">false</NullabilityInfoContextSupport>
+    <_AggressiveAttributeTrimming Condition="'$(_AggressiveAttributeTrimming)' == ''">true</_AggressiveAttributeTrimming>
     <DebuggerSupport Condition="'$(DebuggerSupport)' == '' and '$(Configuration)' != 'Debug'">false</DebuggerSupport>
     <BlazorCacheBootResources Condition="'$(BlazorCacheBootResources)' == ''">true</BlazorCacheBootResources>
 
diff --git a/src/Tasks/Microsoft.NET.Build.Tasks/targets/Microsoft.NET.ILLink.targets b/src/Tasks/Microsoft.NET.Build.Tasks/targets/Microsoft.NET.ILLink.targets
index 8968eeeac1ed..6d5d592006ca 100644
--- a/src/Tasks/Microsoft.NET.Build.Tasks/targets/Microsoft.NET.ILLink.targets
+++ b/src/Tasks/Microsoft.NET.Build.Tasks/targets/Microsoft.NET.ILLink.targets
@@ -43,6 +43,7 @@ Copyright (c) .NET Foundation. All rights reserved.
     <AutoreleasePoolSupport Condition="'$(AutoreleasePoolSupport)' == ''">false</AutoreleasePoolSupport>
     <EnableCppCLIHostActivation Condition="'$(EnableCppCLIHostActivation)' == ''">false</EnableCppCLIHostActivation>
     <_EnableConsumingManagedCodeFromNativeHosting Condition="'$(_EnableConsumingManagedCodeFromNativeHosting)' == ''">false</_EnableConsumingManagedCodeFromNativeHosting>
+    <VerifyDependencyInjectionOpenGenericServiceTrimmability Condition="'$(VerifyDependencyInjectionOpenGenericServiceTrimmability)' == ''">true</VerifyDependencyInjectionOpenGenericServiceTrimmability>
   </PropertyGroup>
 
   <PropertyGroup Condition="'$(SuppressTrimAnalysisWarnings)' == '' And ('$(EnableTrimAnalyzer)' == 'true' Or '$(PublishTrimmed)' == 'true')">
diff --git a/src/Tasks/Microsoft.NET.Build.Tasks/targets/Microsoft.NET.Sdk.targets b/src/Tasks/Microsoft.NET.Build.Tasks/targets/Microsoft.NET.Sdk.targets
index 48f1fc13cebf..fe4b1fd6230b 100644
--- a/src/Tasks/Microsoft.NET.Build.Tasks/targets/Microsoft.NET.Sdk.targets
+++ b/src/Tasks/Microsoft.NET.Build.Tasks/targets/Microsoft.NET.Sdk.targets
@@ -372,6 +372,16 @@ Copyright (c) .NET Foundation. All rights reserved.
     -->
 
   <ItemGroup>
+    <RuntimeHostConfigurationOption Include="Microsoft.Extensions.DependencyInjection.VerifyOpenGenericServiceTrimmability"
+                                    Condition="'$(VerifyDependencyInjectionOpenGenericServiceTrimmability)' != ''"
+                                    Value="$(VerifyDependencyInjectionOpenGenericServiceTrimmability)"
+                                    Trim="true" />
+
+    <RuntimeHostConfigurationOption Include="System.AggressiveAttributeTrimming"
+                                    Condition="'$(_AggressiveAttributeTrimming)' != ''"
+                                    Value="$(_AggressiveAttributeTrimming)"
+                                    Trim="true" />
+
     <RuntimeHostConfigurationOption Include="System.ComponentModel.TypeConverter.EnableUnsafeBinaryFormatterInDesigntimeLicenseContextSerialization"
                                     Condition="'$(EnableUnsafeBinaryFormatterInDesigntimeLicenseContextSerialization)' != ''"
                                     Value="$(EnableUnsafeBinaryFormatterInDesigntimeLicenseContextSerialization)"
@@ -424,6 +434,11 @@ Copyright (c) .NET Foundation. All rights reserved.
                                     Value="$(MetadataUpdaterSupport)"
                                     Trim="true" />
 
+    <RuntimeHostConfigurationOption Include="System.Reflection.NullabilityInfoContext.IsSupported"
+                                    Condition="'$(NullabilityInfoContextSupport)' != ''"
+                                    Value="$(NullabilityInfoContextSupport)"
+                                    Trim="true" />
+
     <RuntimeHostConfigurationOption Include="System.Resources.ResourceManager.AllowCustomResourceTypes"
                                     Condition="'$(CustomResourceTypesSupport)' != ''"
                                     Value="$(CustomResourceTypesSupport)"
diff --git a/src/Tests/Microsoft.NET.Publish.Tests/GivenThatWeWantToPublishAProjectWithAllFeatures.cs b/src/Tests/Microsoft.NET.Publish.Tests/GivenThatWeWantToPublishAProjectWithAllFeatures.cs
index 9096eb76c03e..8176f9597a42 100644
--- a/src/Tests/Microsoft.NET.Publish.Tests/GivenThatWeWantToPublishAProjectWithAllFeatures.cs
+++ b/src/Tests/Microsoft.NET.Publish.Tests/GivenThatWeWantToPublishAProjectWithAllFeatures.cs
@@ -67,6 +67,8 @@ public void It_publishes_the_project_correctly(string targetFramework, string []
             var baselineConfigJsonObject = JObject.Parse(@"{
     ""runtimeOptions"": {
         ""configProperties"": {
+            ""Microsoft.Extensions.DependencyInjection.VerifyOpenGenericServiceTrimmability"": true,
+            ""System.AggressiveAttributeTrimming"": true,
             ""System.ComponentModel.TypeConverter.EnableUnsafeBinaryFormatterInDesigntimeLicenseContextSerialization"": false,
             ""System.Diagnostics.Debugger.IsSupported"": true,
             ""System.Diagnostics.Tracing.EventSource.IsSupported"": false,
@@ -78,6 +80,7 @@ public void It_publishes_the_project_correctly(string targetFramework, string []
             ""System.Net.Http.EnableActivityPropagation"": false,
             ""System.Net.Http.UseNativeHttpHandler"": true,
             ""System.Reflection.Metadata.MetadataUpdater.IsSupported"": false,
+            ""System.Reflection.NullabilityInfoContext.IsSupported"": false,
             ""System.Resources.ResourceManager.AllowCustomResourceTypes"": false,
             ""System.Resources.UseSystemResourceKeys"": true,
             ""System.Runtime.InteropServices.BuiltInComInterop.IsSupported"": false,
diff --git a/src/Tests/Microsoft.NET.Publish.Tests/GivenThatWeWantToRunILLink.cs b/src/Tests/Microsoft.NET.Publish.Tests/GivenThatWeWantToRunILLink.cs
index da7ec860d6f9..3ccecdeab27c 100644
--- a/src/Tests/Microsoft.NET.Publish.Tests/GivenThatWeWantToRunILLink.cs
+++ b/src/Tests/Microsoft.NET.Publish.Tests/GivenThatWeWantToRunILLink.cs
@@ -680,6 +680,8 @@ public void TrimmingOptions_are_defaulted_correctly_on_trimmed_apps(string targe
             {
                 JObject runtimeConfig = JObject.Parse(runtimeConfigContents);
                 JToken configProperties = runtimeConfig["runtimeOptions"]["configProperties"];
+                configProperties["Microsoft.Extensions.DependencyInjection.VerifyOpenGenericServiceTrimmability"].Value<bool>()
+                    .Should().BeTrue();
                 configProperties["System.ComponentModel.TypeConverter.EnableUnsafeBinaryFormatterInDesigntimeLicenseContextSerialization"].Value<bool>()
                     .Should().BeFalse();
                 configProperties["System.Resources.ResourceManager.AllowCustomResourceTypes"].Value<bool>()
@@ -701,6 +703,7 @@ public void TrimmingOptions_are_defaulted_correctly_on_trimmed_apps(string targe
             }
             else
             {
+                runtimeConfigContents.Should().NotContain("Microsoft.Extensions.DependencyInjection.VerifyOpenGenericServiceTrimmability");
                 runtimeConfigContents.Should().NotContain("System.ComponentModel.TypeConverter.EnableUnsafeBinaryFormatterInDesigntimeLicenseContextSerialization");
                 runtimeConfigContents.Should().NotContain("System.Resources.ResourceManager.AllowCustomResourceTypes");
                 runtimeConfigContents.Should().NotContain("System.Runtime.InteropServices.BuiltInComInterop.IsSupported");