Skip to content

An R data package that provides data from Table 1 from Alfred Knudson's seminal 1971 paper, "Mutation and cancer: statistical study of retinoblastoma," in machine-readable format.

dpique/knudson

master
Switch branches/tags
Code

Latest commit

 

Git stats

Files

Permalink
Failed to load latest commit information.
Type
Name
Latest commit message
Commit time
R
 
 
 
 
man
 
 
 
 
 
 
 
 
 
 
 
 

Knudson

This package provides the data from Table 1 from Knudson (1971). This paper, entitled "Mutation and cancer: statistical study of retinoblastoma", provided the basis for the two-hit hypothesis of cancer.

The two-hit hypothesis states that cancer arises via mutation of tumor supressor genes (TSGs), of which there are generally two genetic copies. Some patients are born with a mutation in one of the two copies of a TSG, which predisposes them to cancer.

The vignette also serves as a reproducibility case study that attempts to recreate Figure 1 using the data in Table 1 from Knudson (1971) (see below).

  • k: the data from Table 1 in this paper. This is a dataframe with 48 rows and 8 variables, described below:

    • case: the case number

    • hosp_numb: the hospital id number of the patient

    • sex: the sex of the patient

    • age_at_dx: the age (in months) of the patient at diagnosis

    • r_tum: the number of tumors in the right eye. * if unknown.

    • l_tum: the number of tumors in the left eye. * if unknown.

    • family_hx: Is there a family history of retinoblastoma? If so, lists who was affected.

    • side: Was the retinoblastoma unilateral (unilat) or bilateral (bilat)

Installation

## Install the development version of knudson from github
devtools::install_github("dpique/knudson",
    build_opts=c("--no-resave-data", "--no-manual"),
    build_vignettes=TRUE)

library(knudson)

## open the vignette
vignette("knudson")

About

An R data package that provides data from Table 1 from Alfred Knudson's seminal 1971 paper, "Mutation and cancer: statistical study of retinoblastoma," in machine-readable format.

Resources

Stars

Watchers

Forks

Releases

No releases published

Packages

No packages published

Languages