diff --git a/src/dstack/_internal/core/backends/runpod/compute.py b/src/dstack/_internal/core/backends/runpod/compute.py
index 778e36bd4..29e521d24 100644
--- a/src/dstack/_internal/core/backends/runpod/compute.py
+++ b/src/dstack/_internal/core/backends/runpod/compute.py
@@ -232,9 +232,12 @@ def register_volume(self, volume: Volume) -> VolumeProvisioningData:
     def create_volume(self, volume: Volume) -> VolumeProvisioningData:
         volume_name = generate_unique_volume_name(volume, max_length=MAX_RESOURCE_NAME_LEN)
         size_gb = volume.configuration.size_gb
+        # Runpod regions must be uppercase.
+        # Lowercase regions are accepted in the API but they break Runpod in several ways.
+        region = volume.configuration.region.upper()
         volume_id = self.api_client.create_network_volume(
             name=volume_name,
-            region=volume.configuration.region,
+            region=region,
             size=size_gb,
         )
         return VolumeProvisioningData(