diff --git a/EDAM_dev.owl b/EDAM_dev.owl
index 9cb93c9..94b6ec5 100644
--- a/EDAM_dev.owl
+++ b/EDAM_dev.owl
@@ -1278,7 +1278,7 @@
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://edamontology.org/has_topic"/>
-                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_0159"/>
+                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_0080"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <rdfs:seeAlso>http://en.wikipedia.org/wiki/Sequence_alignment</rdfs:seeAlso>
@@ -1637,7 +1637,7 @@
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://edamontology.org/has_topic"/>
-                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_1770"/>
+                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_0081"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <oboInOwl:hasDefinition>Alignment (superimposition) of molecular tertiary (3D) structures.</oboInOwl:hasDefinition>
@@ -2644,7 +2644,7 @@
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://edamontology.org/has_topic"/>
-                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_0220"/>
+                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_3489"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <oboInOwl:hasDefinition>An index of data of biological relevance.</oboInOwl:hasDefinition>
@@ -2663,7 +2663,7 @@
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://edamontology.org/has_topic"/>
-                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_0220"/>
+                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_3489"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <oboInOwl:hasDefinition>A report of an analysis of an index of biological data.</oboInOwl:hasDefinition>
@@ -11377,7 +11377,7 @@
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://edamontology.org/has_topic"/>
-                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_0620"/>
+                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_0154"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <oboInOwl:hasDefinition>An informative report on a specific drug.</oboInOwl:hasDefinition>
@@ -14083,7 +14083,7 @@
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://edamontology.org/has_topic"/>
-                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_0613"/>
+                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_0154"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <created_in>beta12orEarlier</created_in>
@@ -33093,7 +33093,7 @@ experiments employing a combination of technologies.</oboInOwl:hasDefinition>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://edamontology.org/has_topic"/>
-                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_0090"/>
+                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_3071"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <created_in>beta12orEarlier</created_in>
@@ -39738,7 +39738,7 @@ sequences matching a given sequence motif or pattern, such as a Prosite pattern
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://edamontology.org/has_topic"/>
-                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_2846"/>
+                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_0602"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <created_in>beta12orEarlier</created_in>
@@ -40754,7 +40754,7 @@ sequences matching a given sequence motif or pattern, such as a Prosite pattern
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://edamontology.org/has_topic"/>
-                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_0220"/>
+                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_3489"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <created_in>beta12orEarlier</created_in>
@@ -41213,7 +41213,7 @@ sequences matching a given sequence motif or pattern, such as a Prosite pattern
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://edamontology.org/has_topic"/>
-                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_2846"/>
+                <owl:someValuesFrom rdf:resource="http://edamontology.org/topic_0602"/>
             </owl:Restriction>
         </rdfs:subClassOf>
         <oboInOwl:hasDefinition>Predict a network of gene regulation.</oboInOwl:hasDefinition>