NSMB Tutorials are now available under the 'tutorials' folder as RMarkdown files. The HTML workflows for protein-protein interactions and protein-RNA interactions are available via the links provided.

This package is designed to analyze and visualize crosslinking (XL) data from multiple sources (mainly XL-MS and RBDmap).

Analysis

• Differential analysis

• Crosslinking frequency

• Creation of PDB files for missing peptides

• Mutation and Uniprot Integration (coming soon!)

XL-MS

• Control distances for PDB structures

RBDMap

• Frequency of RNA-likened amino acids

Visualization

• Distance histograms

• Amino acid frequency heatmaps

• 2D: xiNET output

• 3D: PyMOL output

Installation

To download the functions with documentation:

library('devtools')
install_github("egmg726/crisscrosslinker")

Note

This is still the beta release of the package/documentation so please contact me if you come across any issues!