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Visualization of obtained TCR CDR3a amino acid sequences. For this demonstration there are 3 donors across 2 tissues (blood vs. lung) such that all 3 donors have known pulmonary Mtb infections.
The biological question: Are specific TCR sequences, specifically pertaining to MAIT cells, enriched in the lung of individuals with a tuberculosis infection?
Results: Although larger data sets with appropriate controls are needed for cross-cohort statistical comparisons, we observe a trend that supports the hypothesis that certain MAIT TCR are enriched in the lung of the donors.
Eisa Mahyari @eisamahyari Supervised by Dr. David M. Lewinsohn
Dr. Emily Wong
Dr. Marielle C. Gold
Dr. David M. Lewinsohn (PI)