diff --git a/src/core_plugins/timelion/public/app.less b/src/core_plugins/timelion/public/app.less
index 67dc712b4db589..fb90e17fa20668 100644
--- a/src/core_plugins/timelion/public/app.less
+++ b/src/core_plugins/timelion/public/app.less
@@ -152,7 +152,8 @@ timelion-interval {
   left:5px;
   line-height: 10px;
 
-  > div {
+  > .cell-action,
+  > .cell-id {
     display: inline-block;
     font-size: 10px;
     text-align: center;
@@ -169,6 +170,10 @@ timelion-interval {
 
   .cell-action {
     opacity: 0;
+
+    &:focus {
+      opacity: 1;
+    }
   }
 }
 
@@ -188,6 +193,7 @@ timelion-interval {
   overflow-x: hidden;
 }
 
+.ngLegendValue:focus,
 .ngLegendValue:hover {
   text-decoration: underline;
 }
diff --git a/src/core_plugins/timelion/public/directives/cells/cells.html b/src/core_plugins/timelion/public/directives/cells/cells.html
index 8c9dc1c3ccc39f..d1acf0e21b174e 100644
--- a/src/core_plugins/timelion/public/directives/cells/cells.html
+++ b/src/core_plugins/timelion/public/directives/cells/cells.html
@@ -9,15 +9,43 @@
     timelion-grid timelion-grid-rows="state.rows"
     ng-click="onSelect($index)"
     ng-class="{active: $index === state.selected}"
+    kbn-accessible-click
+    aria-label="Timelion chart {{$index + 1}}"
+    aria-current="{{$index === state.selected}}"
     >
 
     <div chart="sheet[$index]" search="onSearch" interval="state.interval"></div>
     <div class="cell-actions">
       <div class="cell-id"><span>{{$index + 1}}</span></div>
 
-      <div class="cell-action" ng-click="removeCell($index)" tooltip="Remove" tooltip-append-to-body="1"><span class="fa fa-remove"></span></div>
-      <div class="cell-action" tooltip="Drag to reorder" tooltip-append-to-body="1" sv-handle><span class="fa fa-arrows"></span></div>
-      <div class="cell-action" ng-click="transient.fullscreen = true" tooltip="Full screen" tooltip-append-to-body="1"><span class="fa fa-expand"></span></div>
+      <button
+        class="cell-action"
+        ng-click="removeCell($index)"
+        tooltip="Remove"
+        tooltip-append-to-body="1"
+        aria-label="Remove chart"
+      >
+        <span class="fa fa-remove"></span>
+      </button>
+      <button
+        class="cell-action"
+        tooltip="Drag to reorder"
+        tooltip-append-to-body="1"
+        sv-handle
+        aria-label="Drag to reorder"
+        tabindex="-1"
+      >
+        <span class="fa fa-arrows"></span>
+      </button>
+      <button
+        class="cell-action"
+        ng-click="transient.fullscreen = true"
+        tooltip="Full screen"
+        tooltip-append-to-body="1"
+        aria-label="Full screen chart"
+      >
+        <span class="fa fa-expand"></span>
+      </button>
     </div>
   </div>
 
diff --git a/src/core_plugins/timelion/public/directives/fullscreen/fullscreen.html b/src/core_plugins/timelion/public/directives/fullscreen/fullscreen.html
index 8601937f83866f..0b5aab4093d465 100644
--- a/src/core_plugins/timelion/public/directives/fullscreen/fullscreen.html
+++ b/src/core_plugins/timelion/public/directives/fullscreen/fullscreen.html
@@ -1,8 +1,14 @@
 <div class="chart-container col-md-12 col-sm-12 col-xs-12" timelion-grid timelion-grid-rows="1">
   <div  chart="series" search="onSearch" interval="state.interval"></div>
   <div class="cell-actions">
-    <div class="cell-fullscreen" ng-click="transient.fullscreen = false" tooltip="Exit full screen" tooltip-append-to-body="1">
+    <button
+      class="cell-fullscreen cell-action"
+      ng-click="transient.fullscreen = false"
+      tooltip="Exit full screen"
+      tooltip-append-to-body="1"
+      aria-label="Exit full screen"
+    >
       <span class="fa fa-compress"></span>
-    </div>
+    </button>
   </div>
 </div>
diff --git a/src/core_plugins/timelion/public/directives/timelion_expression_input.html b/src/core_plugins/timelion/public/directives/timelion_expression_input.html
index f53a26a7da51ad..01f92a0bf8a138 100644
--- a/src/core_plugins/timelion/public/directives/timelion_expression_input.html
+++ b/src/core_plugins/timelion/public/directives/timelion_expression_input.html
@@ -1,7 +1,16 @@
-<div class="timelionExpressionInputContainer">
+<div
+  class="timelionExpressionInputContainer"
+  role="combobox"
+  aria-expanded="{{functionSuggestions.isVisible}}"
+  aria-owns="timelionSuggestionList"
+  aria-haspopup="true"
+>
+  <!-- The `role=textbox` is required by VoiceOver to properly detect the autocompletion.
+       For some reasons it doesn't work without it (even though the default role of
+       the element is textbox anyway). -->
   <textarea
     data-expression-input
-    type="text"
+    role="textbox"
     rows="{{ rows }}"
     class="timelionExpressionInput kuiTextArea fullWidth"
     placeholder="Try a query with .es(*)"
@@ -12,6 +21,11 @@
     ng-blur="onBlurInput()"
     ng-mousedown="onMouseDownInput()"
     ng-mouseup="onMouseUpInput()"
+    aria-label="Timelion expression"
+    aria-multiline="false"
+    aria-autocomplete="list"
+    aria-controls="timelionSuggestionList"
+    aria-activedescendant="{{ getActiveSuggestionId() }}"
   ></textarea>
 
   <timelion-expression-suggestions
diff --git a/src/core_plugins/timelion/public/directives/timelion_expression_input.js b/src/core_plugins/timelion/public/directives/timelion_expression_input.js
index c9da77568138a0..b378d68d65e41a 100644
--- a/src/core_plugins/timelion/public/directives/timelion_expression_input.js
+++ b/src/core_plugins/timelion/public/directives/timelion_expression_input.js
@@ -166,8 +166,12 @@ app.directive('timelionExpressionInput', function ($document, $http, $interval,
             break;
 
           case comboBoxKeyCodes.TAB:
-            // If there are no suggestions, the user tabs to the next input.
-            if (scope.functionSuggestions.isEmpty()) {
+            // If there are no suggestions or none is selected, the user tabs to the next input.
+            if (scope.functionSuggestions.isEmpty() || scope.functionSuggestions.index < 0) {
+              // Before letting the tab be handled to focus the next element
+              // we need to hide the suggestions, otherwise it will focus these
+              // instead of the time interval select.
+              scope.functionSuggestions.hide();
               return;
             }
 
@@ -177,7 +181,7 @@ app.directive('timelionExpressionInput', function ($document, $http, $interval,
             break;
 
           case comboBoxKeyCodes.ENTER:
-            if (e.metaKey) {
+            if (e.metaKey || e.ctrlKey) {
               // Re-render the chart when the user hits CMD+ENTER.
               e.preventDefault();
               scope.updateChart();
@@ -206,6 +210,13 @@ app.directive('timelionExpressionInput', function ($document, $http, $interval,
         insertSuggestionIntoExpression(index);
       };
 
+      scope.getActiveSuggestionId = () => {
+        if(scope.functionSuggestions.isVisible && scope.functionSuggestions.index > -1) {
+          return `timelionSuggestion${scope.functionSuggestions.index}`;
+        }
+        return '';
+      };
+
       init();
     }
   };
diff --git a/src/core_plugins/timelion/public/directives/timelion_expression_input_helpers.js b/src/core_plugins/timelion/public/directives/timelion_expression_input_helpers.js
index a90fd845730c0e..d660eb3656e5da 100644
--- a/src/core_plugins/timelion/public/directives/timelion_expression_input_helpers.js
+++ b/src/core_plugins/timelion/public/directives/timelion_expression_input_helpers.js
@@ -6,7 +6,7 @@ export class FunctionSuggestions {
   }
 
   reset() {
-    this.index = 0;
+    this.index = -1;
     this.list = [];
     this.isVisible = false;
   }
@@ -14,9 +14,13 @@ export class FunctionSuggestions {
   setList(list) {
     this.list = list;
 
-    // We may get a shorter list than the one we have now, so we need to make sure our index doesn't
-    // fall outside of the new list's range.
-    this.index = Math.max(0, Math.min(this.index, this.list.length - 1));
+    // Only try to position index inside of list range, when it was already focused
+    // beforehand (i.e. not -1)
+    if (this.index > -1) {
+      // We may get a shorter list than the one we have now, so we need to make sure our index doesn't
+      // fall outside of the new list's range.
+      this.index = Math.max(0, Math.min(this.index, this.list.length - 1));
+    }
   }
 
   getCount() {
diff --git a/src/core_plugins/timelion/public/directives/timelion_expression_suggestions/timelion_expression_suggestions.html b/src/core_plugins/timelion/public/directives/timelion_expression_suggestions/timelion_expression_suggestions.html
index 5f080d2b7d5a7a..982d9472fa526a 100644
--- a/src/core_plugins/timelion/public/directives/timelion_expression_suggestions/timelion_expression_suggestions.html
+++ b/src/core_plugins/timelion/public/directives/timelion_expression_suggestions/timelion_expression_suggestions.html
@@ -1,19 +1,26 @@
 <div
+  id="timelionSuggestionList"
   class="suggestions"
+  role="listbox"
   ng-class="{ 'suggestions-isPopover': shouldPopover === 'true' }"
   data-suggestions-list
 >
   <div
     class="suggestion"
+    id="timelionSuggestion{{$index}}"
+    role="option"
+    tabindex="0"
     data-suggestion-list-item
     ng-class="{active: $index === selectedIndex}"
     ng-repeat="suggestion in suggestions track by $index | orderBy:'name'"
     ng-mousedown="onMouseDown($event)"
     ng-click="onClickSuggestion({ suggestionIndex: $index })"
+    aria-label="{{suggestion.name}}"
+    aria-describedby="timelionSuggestionDescription{{$index}}"
   >
     <h4>
       <strong>.{{suggestion.name}}()</strong>
-      <small>
+      <small id="timelionSuggestionDescription{{$index}}">
         {{suggestion.help}}
         {{suggestion.chainable ? '(Chainable)' : '(Data Source)'}}
       </small>
diff --git a/src/core_plugins/timelion/public/directives/timelion_interval/timelion_interval.html b/src/core_plugins/timelion/public/directives/timelion_interval/timelion_interval.html
index de4aca963c78bf..bed82008688173 100644
--- a/src/core_plugins/timelion/public/directives/timelion_interval/timelion_interval.html
+++ b/src/core_plugins/timelion/public/directives/timelion_interval/timelion_interval.html
@@ -1,5 +1,6 @@
 <input
   input-focus
+  aria-label="Custom interval"
   class="kuiTextInput timelion-interval-custom"
   ng-show="interval === 'other'"
   ng-class="{ 'timelion-interval-custom-compact': interval === 'other' }"
@@ -8,7 +9,14 @@
   id="timelionInterval"
   aria-label="Select interval"
   class="kuiSelect timelion-interval-presets"
-  ng-options="intervalOption for intervalOption in intervalOptions"
   ng-class="{ 'timelion-interval-presets-compact': interval === 'other'}"
   ng-model="interval"
-></select>
+>
+  <option
+    ng-repeat="intervalOption in intervalOptions"
+    aria-label="{{::intervalLabels[intervalOption]}}"
+    value="{{::intervalOption}}"
+  >
+      {{::intervalOption}}
+  </option>
+</select>
diff --git a/src/core_plugins/timelion/public/directives/timelion_interval/timelion_interval.js b/src/core_plugins/timelion/public/directives/timelion_interval/timelion_interval.js
index 79e79fb573f452..7ea8b5c7247d09 100644
--- a/src/core_plugins/timelion/public/directives/timelion_interval/timelion_interval.js
+++ b/src/core_plugins/timelion/public/directives/timelion_interval/timelion_interval.js
@@ -15,6 +15,17 @@ app.directive('timelionInterval', function ($compile, $timeout) {
     template,
     link: function ($scope, $elem) {
       $scope.intervalOptions = ['auto', '1s', '1m', '1h', '1d', '1w', '1M', '1y', 'other'];
+      $scope.intervalLabels = {
+        'auto': 'auto',
+        '1s': '1 second',
+        '1m': '1 minute',
+        '1h': '1 hour',
+        '1d': '1 day',
+        '1w': '1 week',
+        '1M': '1 month',
+        '1y': '1 year',
+        'other': 'other'
+      };
 
       $scope.$watch('model', function (newVal, oldVal) {
         // Only run this on initialization
diff --git a/src/core_plugins/timelion/public/panels/timechart/schema.js b/src/core_plugins/timelion/public/panels/timechart/schema.js
index 50e7bcb2a61b6b..1b05c6c0a94abb 100644
--- a/src/core_plugins/timelion/public/panels/timechart/schema.js
+++ b/src/core_plugins/timelion/public/panels/timechart/schema.js
@@ -63,7 +63,7 @@ export default function timechartFn(Private, config, $rootScope, timefilter, $co
             position: 'nw',
             labelBoxBorderColor: 'rgb(255,255,255,0)',
             labelFormatter: function (label, series) {
-              return '<span class="ngLegendValue" ng-click="toggleSeries(' + series._id + ')">' +
+              return '<span class="ngLegendValue" kbn-accessible-click ng-click="toggleSeries(' + series._id + ')">' +
                 label +
                 '<span class="ngLegendValueNumber"></span></span>';
             }
diff --git a/src/core_plugins/timelion/public/partials/save_sheet.html b/src/core_plugins/timelion/public/partials/save_sheet.html
index 68078c3a615a85..c96e3ef0270f5f 100644
--- a/src/core_plugins/timelion/public/partials/save_sheet.html
+++ b/src/core_plugins/timelion/public/partials/save_sheet.html
@@ -1,12 +1,12 @@
 <div class="list-group">
-  <a class="list-group-item" ng-click="section = 'sheet'">
+  <button class="list-group-item" ng-click="section = 'sheet'" type="button">
     <h4 class="list-group-item-heading">Save entire Timelion sheet</h4>
     <p  class="list-group-item-text">
       You want this option if you mostly use Timelion expressions from within the Timelion app and don't need to
       add Timelion charts to Kibana dashboards. You may also want this if you make use of references to other
       panels.
     </p>
-  </a>
+  </button>
 
   <div class="list-group-item" ng-show="section == 'sheet'">
     <form role="form" class="container-fluid" ng-submit="opts.saveSheet()">
@@ -24,7 +24,7 @@ <h4 class="list-group-item-heading">Save entire Timelion sheet</h4>
     </form>
   </div>
 
-  <a class="list-group-item" ng-click="section = 'expression'">
+  <button class="list-group-item" ng-click="section = 'expression'" type="button">
     <h4 class="list-group-item-heading">Save current expression as Kibana dashboard panel</h4>
     <p class="list-group-item-text">
       Need to add a chart to a Kibana dashboard? We can do that! This option will save your currently selected
@@ -32,7 +32,7 @@ <h4 class="list-group-item-heading">Save current expression as Kibana dashboard
       use references to other panels you will need to remove the refences by copying the referenced expression
       directly into the expression you are saving. Click a chart to select a different expression to save.
     </p>
-  </a>
+  </button>
 
   <div class="list-group-item" ng-show="section == 'expression'">
     <form role="form" class="container-fluid" ng-submit="opts.saveExpression(panelTitle)">
diff --git a/src/core_plugins/timelion/public/partials/sheet_options.html b/src/core_plugins/timelion/public/partials/sheet_options.html
index ed30161dcf15f3..004f1db538599f 100644
--- a/src/core_plugins/timelion/public/partials/sheet_options.html
+++ b/src/core_plugins/timelion/public/partials/sheet_options.html
@@ -2,16 +2,18 @@
   <div class="kuiLocalDropdownTitle">Sheet options</div>
   <div>
     <div class="form-group col-md-6">
-      <label>Columns <small>Column count must divide evenly into 12</small></label>
+      <label for="timelionColCount">Columns <small>Column count must divide evenly into 12</small></label>
       <select class="form-control"
+        id="timelionColCount"
         ng-change="opts.search()"
         ng-options="column for column in [1, 2, 3, 4, 6, 12]"
         ng-model="opts.state.columns">
       </select>
     </div>
     <div class="form-group col-md-6">
-      <label>Rows <small>This is a target based on the current window height</small></label>
+      <label for="timelionRowCount">Rows <small>This is a target based on the current window height</small></label>
       <select class="form-control"
+        id="timelionRowCount"
         ng-change="opts.search()"
         ng-options="row for row in [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12]"
         ng-model="opts.state.rows">
diff --git a/src/ui/public/partials/saved_object_finder.html b/src/ui/public/partials/saved_object_finder.html
index 04e3f38bb5401c..daf6bd8991c493 100644
--- a/src/ui/public/partials/saved_object_finder.html
+++ b/src/ui/public/partials/saved_object_finder.html
@@ -52,12 +52,19 @@
   class="kuiVerticalRhythm"
 >
   <ul class="li-striped list-group list-group-menu" ng-class="{'select-mode': finder.selector.enabled}">
-    <li class="list-group-item" ng-click="finder.sortHits(finder.hits)">
+    <li
+      class="list-group-item"
+      ng-click="finder.sortHits(finder.hits)"
+      kbn-accessible-click
+      aria-live="assertive"
+      >
       <span class="paginate-heading">
+        <span class="kuiScreenReaderOnly">Sort by</span>
         Name
         <span
           class="fa"
           ng-class="finder.isAscending ? 'fa-caret-up' : 'fa-caret-down'">
+          <span class="kuiScreenReaderOnly">({{finder.isAscending ? 'ascending' : 'descending'}})</span>
         </span>
       </span>
     </li>