diff --git a/lib/elixir/lib/kernel.ex b/lib/elixir/lib/kernel.ex
index 7c8e854549..096408b177 100644
--- a/lib/elixir/lib/kernel.ex
+++ b/lib/elixir/lib/kernel.ex
@@ -6647,16 +6647,26 @@ defmodule Kernel do
   end
 
   defp compile_regex(binary_or_tuple, options) do
-    # TODO: Remove this when we require Erlang/OTP 28+
-    case is_binary(binary_or_tuple) and :erlang.system_info(:otp_release) < [?2, ?8] do
+    bin_opts = :binary.list_to_bin(options)
+
+    # TODO: Remove this when we require Erlang/OTP 28.1+
+    case is_binary(binary_or_tuple) and compile_time_regexes_supported?() do
       true ->
-        Macro.escape(Regex.compile!(binary_or_tuple, :binary.list_to_bin(options)))
+        Macro.escape(Regex.compile!(binary_or_tuple, bin_opts))
 
       false ->
-        quote(do: Regex.compile!(unquote(binary_or_tuple), unquote(:binary.list_to_bin(options))))
+        quote(do: Regex.compile!(unquote(binary_or_tuple), unquote(bin_opts)))
     end
   end
 
+  defp compile_time_regexes_supported? do
+    # OTP 28.0 introduced refs in patterns, which can't be used in AST anymore
+    # OTP 28.1 introduced :re.import/1 which allows us to fix this in Macro.escape
+    :erlang.system_info(:otp_release) < [?2, ?8] or
+      (Code.ensure_loaded?(:re) and
+         function_exported?(:re, :import, 1))
+  end
+
   @doc ~S"""
   Handles the sigil `~D` for dates.
 
diff --git a/lib/elixir/src/elixir_quote.erl b/lib/elixir/src/elixir_quote.erl
index 4260985f28..c1199df636 100644
--- a/lib/elixir/src/elixir_quote.erl
+++ b/lib/elixir/src/elixir_quote.erl
@@ -168,9 +168,28 @@ do_escape(BitString, _) when is_bitstring(BitString) ->
       {'<<>>', [], [{'::', [], [Bits, {size, [], [Size]}]}, {'::', [], [Bytes, {binary, [], nil}]}]}
   end;
 
+do_escape(#{
+  '__struct__' := 'Elixir.Regex',
+  're_pattern' := {re_pattern, _, _, _, Ref},
+  'source' := Source,
+  'opts' := Opts
+} = Map, Q) when is_reference(Ref), is_binary(Source), is_list(Opts)  ->
+  case erlang:function_exported(re, import, 1) of
+    true ->
+      {ok, ExportedPattern} = re:compile(Source, [export | Opts]),
+      PatternAst = {{'.', [], ['re', 'import']}, [], [do_escape(ExportedPattern, Q)]},
+      {'%{}', [], [
+        {'__struct__', 'Elixir.Regex'},
+        {'re_pattern', PatternAst},
+        {'source', Source},
+        {'opts', do_escape(Opts, Q)}
+      ]};
+    false ->
+      escape_map(Map, Q)
+  end;
+
 do_escape(Map, Q) when is_map(Map) ->
-  TT = [escape_map_key_value(K, V, Map, Q) || {K, V} <- lists:sort(maps:to_list(Map))],
-  {'%{}', [], TT};
+  escape_map(Map, Q);
 
 do_escape([], _) ->
   [];
@@ -203,6 +222,10 @@ do_escape(Fun, _) when is_function(Fun) ->
 do_escape(Other, _) ->
   bad_escape(Other).
 
+escape_map(Map, Q) ->
+  TT = [escape_map_key_value(K, V, Map, Q) || {K, V} <- lists:sort(maps:to_list(Map))],
+  {'%{}', [], TT}.
+
 escape_map_key_value(K, V, Map, Q) ->
   MaybeRef = if
     is_reference(V) -> V;
diff --git a/lib/elixir/test/elixir/macro_test.exs b/lib/elixir/test/elixir/macro_test.exs
index 3c8944defd..61a48fcc4d 100644
--- a/lib/elixir/test/elixir/macro_test.exs
+++ b/lib/elixir/test/elixir/macro_test.exs
@@ -141,11 +141,27 @@ defmodule MacroTest do
       assert Macro.escape({:quote, [], [[do: :foo]]}) == {:{}, [], [:quote, [], [[do: :foo]]]}
     end
 
-    test "inspects container when a reference cannot be escaped" do
+    @tag skip: System.otp_release() < "28" or function_exported?(:re, :import, 1)
+    test "escape container when a reference cannot be escaped" do
       assert_raise ArgumentError, ~r"~r/foo/ contains a reference", fn ->
         Macro.escape(%{~r/foo/ | re_pattern: {:re_pattern, 0, 0, 0, make_ref()}})
       end
     end
+
+    @tag skip: not function_exported?(:re, :import, 1)
+    test "escape regex will remove references and replace it by a call to :re.import/1" do
+      assert {
+               :%{},
+               [],
+               [
+                 __struct__: Regex,
+                 re_pattern:
+                   {{:., [], [:re, :import]}, [], [{:{}, [], [:re_exported_pattern | _]}]},
+                 source: "foo",
+                 opts: []
+               ]
+             } = Macro.escape(%{~r/foo/ | re_pattern: {:re_pattern, 0, 0, 0, make_ref()}})
+    end
   end
 
   describe "expand_once/2" do