diff --git a/packages/react-native/ReactCommon/jsc/JSCRuntime.cpp b/packages/react-native/ReactCommon/jsc/JSCRuntime.cpp
index 33f7db44d3a76c..e63260acb21b18 100644
--- a/packages/react-native/ReactCommon/jsc/JSCRuntime.cpp
+++ b/packages/react-native/ReactCommon/jsc/JSCRuntime.cpp
@@ -377,11 +377,13 @@ JSCRuntime::JSCRuntime(JSGlobalContextRef ctx)
 {
 #ifndef NDEBUG
 #ifdef _JSC_HAS_INSPECTABLE
+#if (__OSX_AVAILABLE_STARTING(MAC_NA, IPHONE_16_4))
   if (__builtin_available(macOS 13.3, iOS 16.4, tvOS 16.4, *)) {
     JSGlobalContextSetInspectable(ctx_, true);
   }
 #endif
 #endif
+#endif
 }
 
 JSCRuntime::~JSCRuntime() {