diff --git a/packages/react-events/src/dom/Press.js b/packages/react-events/src/dom/Press.js
index ecd26ff7f49f..ce8b745254c6 100644
--- a/packages/react-events/src/dom/Press.js
+++ b/packages/react-events/src/dom/Press.js
@@ -476,6 +476,19 @@ function handleStopPropagation(
   }
 }
 
+// After some investigation work, screen reader virtual
+// clicks (NVDA, Jaws, VoiceOver) do not have co-ords associated with the click
+// event and "detail" is always 0 (where normal clicks are > 0)
+function isScreenReaderVirtualClick(nativeEvent): boolean {
+  return (
+    nativeEvent.detail === 0 &&
+    nativeEvent.screenX === 0 &&
+    nativeEvent.screenY === 0 &&
+    nativeEvent.clientX === 0 &&
+    nativeEvent.clientY === 0
+  );
+}
+
 function targetIsDocument(target: null | Node): boolean {
   // When target is null, it is the root
   return target === null || target.nodeType === 9;
@@ -617,6 +630,13 @@ const pressResponderImpl = {
         if (state.shouldPreventClick) {
           nativeEvent.preventDefault();
         }
+        const onPress = props.onPress;
+
+        if (isFunction(onPress) && isScreenReaderVirtualClick(nativeEvent)) {
+          state.pointerType = 'keyboard';
+          state.pressTarget = event.responderTarget;
+          dispatchEvent(event, onPress, context, state, 'press', DiscreteEvent);
+        }
         break;
       }
     }
diff --git a/packages/react-events/src/dom/__tests__/Press-test.internal.js b/packages/react-events/src/dom/__tests__/Press-test.internal.js
index b1ac12e24c7e..159a039bbc69 100644
--- a/packages/react-events/src/dom/__tests__/Press-test.internal.js
+++ b/packages/react-events/src/dom/__tests__/Press-test.internal.js
@@ -420,6 +420,18 @@ describe.each(environmentTable)('Press responder', hasPointerEvents => {
       innerTarget.pointerup({pointerType: 'mouse'});
       expect(onPress).toBeCalled();
     });
+
+    it('is called once after virtual screen reader "click" event', () => {
+      const target = createEventTarget(ref.current);
+      target.virtualclick();
+      expect(onPress).toHaveBeenCalledTimes(1);
+      expect(onPress).toHaveBeenCalledWith(
+        expect.objectContaining({
+          pointerType: 'keyboard',
+          type: 'press',
+        }),
+      );
+    });
   });
 
   describe('onPressMove', () => {
diff --git a/packages/react-events/src/dom/testing-library/domEvents.js b/packages/react-events/src/dom/testing-library/domEvents.js
index 010b0c345ad8..876ba4bd66d4 100644
--- a/packages/react-events/src/dom/testing-library/domEvents.js
+++ b/packages/react-events/src/dom/testing-library/domEvents.js
@@ -170,28 +170,30 @@ function createMouseEvent(
     x = 0,
     y = 0,
   } = {},
+  virtual = false,
 ) {
   const modifierState = {altKey, ctrlKey, metaKey, shiftKey};
 
   return createEvent(type, {
     altKey,
     buttons,
-    clientX: x,
-    clientY: y,
+    clientX: virtual ? 0 : x,
+    clientY: virtual ? 0 : y,
     ctrlKey,
+    detail: virtual ? 0 : 1,
     getModifierState(keyArg) {
       createGetModifierState(keyArg, modifierState);
     },
     metaKey,
-    movementX,
-    movementY,
-    offsetX,
-    offsetY,
-    pageX: pageX || x,
-    pageY: pageY || y,
+    movementX: virtual ? 0 : movementX,
+    movementY: virtual ? 0 : movementY,
+    offsetX: virtual ? 0 : offsetX,
+    offsetY: virtual ? 0 : offsetY,
+    pageX: virtual ? 0 : pageX || x,
+    pageY: virtual ? 0 : pageY || y,
     preventDefault,
-    screenX: x,
-    screenY: y + defaultBrowserChromeSize,
+    screenX: virtual ? 0 : x,
+    screenY: virtual ? 0 : y + defaultBrowserChromeSize,
     shiftKey,
   });
 }
@@ -251,7 +253,11 @@ export function blur({relatedTarget} = {}) {
 }
 
 export function click(payload) {
-  return createMouseEvent('click', payload);
+  return createMouseEvent('click', payload, false);
+}
+
+export function virtualclick(payload) {
+  return createMouseEvent('click', payload, true);
 }
 
 export function contextmenu(payload) {
diff --git a/packages/react-events/src/dom/testing-library/index.js b/packages/react-events/src/dom/testing-library/index.js
index e1377f6d70e0..6c8f6f198894 100644
--- a/packages/react-events/src/dom/testing-library/index.js
+++ b/packages/react-events/src/dom/testing-library/index.js
@@ -44,6 +44,9 @@ const createEventTarget = node => ({
   keyup(payload) {
     node.dispatchEvent(domEvents.keyup(payload));
   },
+  virtualclick(payload) {
+    node.dispatchEvent(domEvents.virtualclick(payload));
+  },
   scroll(payload) {
     node.dispatchEvent(domEvents.scroll(payload));
   },