diff --git a/packages/react-dom/src/events/DOMEventResponderSystem.js b/packages/react-dom/src/events/DOMEventResponderSystem.js
index f68a682d3227..a318f90ab2ce 100644
--- a/packages/react-dom/src/events/DOMEventResponderSystem.js
+++ b/packages/react-dom/src/events/DOMEventResponderSystem.js
@@ -234,10 +234,11 @@ const eventResponderContext: ReactDOMResponderContext = {
     validateResponderContext();
     const childFiber = getClosestInstanceFromNode(childTarget);
     const parentFiber = getClosestInstanceFromNode(parentTarget);
+    const parentAlternateFiber = parentFiber.alternate;
 
     let node = childFiber;
     while (node !== null) {
-      if (node === parentFiber) {
+      if (node === parentFiber || node === parentAlternateFiber) {
         return true;
       }
       node = node.return;
diff --git a/packages/react-events/src/dom/Press.js b/packages/react-events/src/dom/Press.js
index f92b926c88d9..dcffeaa7e1ec 100644
--- a/packages/react-events/src/dom/Press.js
+++ b/packages/react-events/src/dom/Press.js
@@ -837,20 +837,22 @@ const PressResponder: ReactDOMEventResponder = {
         }
         const pressTarget = state.pressTarget;
 
-        if (
-          pressTarget !== null &&
-          !targetIsDocument(pressTarget) &&
-          (pointerType !== 'mouse' ||
-            !context.isTargetWithinNode(target, pressTarget))
-        ) {
-          // Calculate the responder region we use for deactivation, as the
-          // element dimensions may have changed since activation.
-          updateIsPressWithinResponderRegion(
-            touchEvent || nativeEvent,
-            context,
-            props,
-            state,
-          );
+        if (pressTarget !== null && !targetIsDocument(pressTarget)) {
+          if (
+            pointerType === 'mouse' &&
+            context.isTargetWithinNode(target, pressTarget)
+          ) {
+            state.isPressWithinResponderRegion = true;
+          } else {
+            // Calculate the responder region we use for deactivation, as the
+            // element dimensions may have changed since activation.
+            updateIsPressWithinResponderRegion(
+              touchEvent || nativeEvent,
+              context,
+              props,
+              state,
+            );
+          }
         }
 
         if (state.isPressWithinResponderRegion) {
@@ -958,19 +960,24 @@ const PressResponder: ReactDOMEventResponder = {
             if (
               !isKeyboardEvent &&
               pressTarget !== null &&
-              !targetIsDocument(pressTarget) &&
-              (pointerType !== 'mouse' ||
-                !context.isTargetWithinNode(target, pressTarget))
+              !targetIsDocument(pressTarget)
             ) {
-              // If the event target isn't within the press target, check if we're still
-              // within the responder region. The region may have changed if the
-              // element's layout was modified after activation.
-              updateIsPressWithinResponderRegion(
-                touchEvent || nativeEvent,
-                context,
-                props,
-                state,
-              );
+              if (
+                pointerType === 'mouse' &&
+                context.isTargetWithinNode(target, pressTarget)
+              ) {
+                state.isPressWithinResponderRegion = true;
+              } else {
+                // If the event target isn't within the press target, check if we're still
+                // within the responder region. The region may have changed if the
+                // element's layout was modified after activation.
+                updateIsPressWithinResponderRegion(
+                  touchEvent || nativeEvent,
+                  context,
+                  props,
+                  state,
+                );
+              }
             }
             if (state.isPressWithinResponderRegion && button !== 1) {
               if (
diff --git a/packages/react-events/src/dom/__tests__/Press-test.internal.js b/packages/react-events/src/dom/__tests__/Press-test.internal.js
index f5f2f7db4f31..91020fa96fb9 100644
--- a/packages/react-events/src/dom/__tests__/Press-test.internal.js
+++ b/packages/react-events/src/dom/__tests__/Press-test.internal.js
@@ -812,6 +812,32 @@ describe('Event responder: Press', () => {
       );
     });
 
+    it('is called if target rect is not right but the target is (for mouse events)', () => {
+      const buttonRef = React.createRef();
+      const divRef = React.createRef();
+      const element = (
+        <Press onPress={onPress}>
+          <div ref={divRef}>
+            <button ref={buttonRef} />
+          </div>
+        </Press>
+      );
+      ReactDOM.render(element, container);
+      divRef.current.getBoundingClientRect = () => ({
+        left: 0,
+        right: 0,
+        bottom: 0,
+        top: 0,
+      });
+      buttonRef.current.dispatchEvent(
+        createEvent('pointerdown', {pointerType: 'mouse'}),
+      );
+      buttonRef.current.dispatchEvent(
+        createEvent('pointerup', {pointerType: 'mouse'}),
+      );
+      expect(onPress).toBeCalled();
+    });
+
     // No PointerEvent fallbacks
     // TODO: jsdom missing APIs
     // it('is called after "touchend" event', () => {