diff --git a/packages/react-cache/src/ReactCacheOld.js b/packages/react-cache/src/ReactCacheOld.js
index 99716076984c..db316c7422db 100644
--- a/packages/react-cache/src/ReactCacheOld.js
+++ b/packages/react-cache/src/ReactCacheOld.js
@@ -125,7 +125,6 @@ function accessResult<I, K, V>(
       status: Pending,
       value: thenable,
     };
-    // $FlowFixMe[escaped-generic] discovered when updating Flow
     const newEntry = lru.add(newResult, deleteEntry.bind(null, resource, key));
     entriesForResource.set(key, newEntry);
     return newResult;
diff --git a/packages/react-devtools-core/src/backend.js b/packages/react-devtools-core/src/backend.js
index f14ece0eefd1..d2127b6d1636 100644
--- a/packages/react-devtools-core/src/backend.js
+++ b/packages/react-devtools-core/src/backend.js
@@ -148,7 +148,6 @@ export function connectToDevTools(options: ?ConnectOptions) {
         }
       },
     });
-    // $FlowFixMe[incompatible-use] found when upgrading Flow
     bridge.addListener(
       'updateComponentFilters',
       (componentFilters: Array<ComponentFilter>) => {
diff --git a/packages/react-devtools-inline/src/backend.js b/packages/react-devtools-inline/src/backend.js
index 659b6c8521c9..72d56cefe909 100644
--- a/packages/react-devtools-inline/src/backend.js
+++ b/packages/react-devtools-inline/src/backend.js
@@ -81,7 +81,6 @@ export function activate(
     bridge,
   }: {
     bridge?: BackendBridge,
-    // $FlowFixMe[incompatible-exact]
   } = {},
 ): void {
   if (bridge == null) {
diff --git a/packages/react-devtools-inline/src/frontend.js b/packages/react-devtools-inline/src/frontend.js
index 018ce76c5df2..5b9dd6e66887 100644
--- a/packages/react-devtools-inline/src/frontend.js
+++ b/packages/react-devtools-inline/src/frontend.js
@@ -63,7 +63,6 @@ export function initialize(
   }: {
     bridge?: FrontendBridge,
     store?: Store,
-    // $FlowFixMe[incompatible-exact]
   } = {},
 ): React.AbstractComponent<Props, mixed> {
   if (bridge == null) {
diff --git a/packages/react-devtools-shared/src/backend/utils.js b/packages/react-devtools-shared/src/backend/utils.js
index 03e7800819af..37f83f309980 100644
--- a/packages/react-devtools-shared/src/backend/utils.js
+++ b/packages/react-devtools-shared/src/backend/utils.js
@@ -151,7 +151,6 @@ export function serializeToString(data: any): string {
       }
       cache.add(value);
     }
-    // $FlowFixMe
     if (typeof value === 'bigint') {
       return value.toString() + 'n';
     }
diff --git a/packages/react-devtools-shell/src/app/DeeplyNestedComponents/index.js b/packages/react-devtools-shell/src/app/DeeplyNestedComponents/index.js
index 8c9a02e5e0c7..f1369896eda0 100644
--- a/packages/react-devtools-shell/src/app/DeeplyNestedComponents/index.js
+++ b/packages/react-devtools-shell/src/app/DeeplyNestedComponents/index.js
@@ -17,7 +17,6 @@ function wrapWithHoc(Component: () => any, index: number) {
 
   const displayName = (Component: any).displayName || Component.name;
 
-  // $FlowFixMe[incompatible-type] found when upgrading Flow
   HOC.displayName = `withHoc${index}(${displayName})`;
   return HOC;
 }
diff --git a/packages/react-devtools-shell/src/app/InspectableElements/UnserializableProps.js b/packages/react-devtools-shell/src/app/InspectableElements/UnserializableProps.js
index 9d006fb01f86..a5d2c33de8ef 100644
--- a/packages/react-devtools-shell/src/app/InspectableElements/UnserializableProps.js
+++ b/packages/react-devtools-shell/src/app/InspectableElements/UnserializableProps.js
@@ -31,7 +31,6 @@ const immutable = Immutable.fromJS({
     xyz: 1,
   },
 });
-// $FlowFixMe
 const bigInt = BigInt(123); // eslint-disable-line no-undef
 
 export default function UnserializableProps(): React.Node {
diff --git a/packages/react-dom-bindings/src/client/ReactDOMFloatClient.js b/packages/react-dom-bindings/src/client/ReactDOMFloatClient.js
index cfb770711fb9..cfcdabdb28ab 100644
--- a/packages/react-dom-bindings/src/client/ReactDOMFloatClient.js
+++ b/packages/react-dom-bindings/src/client/ReactDOMFloatClient.js
@@ -201,7 +201,6 @@ function getRootNode(container: Container): FloatRoot {
 
 function getCurrentResourceRoot(): null | FloatRoot {
   const currentContainer = getCurrentRootHostContainer();
-  // $FlowFixMe flow should know currentContainer is a Node and has getRootNode
   return currentContainer ? getRootNode(currentContainer) : null;
 }
 
diff --git a/packages/react-dom-bindings/src/server/ReactDOMFloatServer.js b/packages/react-dom-bindings/src/server/ReactDOMFloatServer.js
index d25638809db2..e8aecf06c155 100644
--- a/packages/react-dom-bindings/src/server/ReactDOMFloatServer.js
+++ b/packages/react-dom-bindings/src/server/ReactDOMFloatServer.js
@@ -782,11 +782,9 @@ export function resourcesFromLink(props: Props): boolean {
         if (__DEV__) {
           validateLinkPropsForStyleResource(props);
         }
-        // $FlowFixMe[incompatible-use] found when upgrading Flow
         let preloadResource = resources.preloadsMap.get(href);
         if (!preloadResource) {
           preloadResource = createPreloadResource(
-            // $FlowFixMe[incompatible-call] found when upgrading Flow
             resources,
             href,
             'style',
@@ -937,7 +935,6 @@ export function resourcesFromScript(props: Props): boolean {
       let preloadResource = resources.preloadsMap.get(src);
       if (!preloadResource) {
         preloadResource = createPreloadResource(
-          // $FlowFixMe[incompatible-call] found when upgrading Flow
           resources,
           src,
           'script',
diff --git a/packages/react-reconciler/src/ReactFiberBeginWork.js b/packages/react-reconciler/src/ReactFiberBeginWork.js
index 01c531ab034e..fc593516be33 100644
--- a/packages/react-reconciler/src/ReactFiberBeginWork.js
+++ b/packages/react-reconciler/src/ReactFiberBeginWork.js
@@ -599,7 +599,6 @@ function updateSimpleMemoComponent(
         try {
           outerMemoType = init(payload);
         } catch (x) {
-          // $FlowFixMe[incompatible-type] found when upgrading Flow
           outerMemoType = null;
         }
         // Inner propTypes will be validated in the function component path.
diff --git a/packages/react-reconciler/src/ReactFiberCommitWork.js b/packages/react-reconciler/src/ReactFiberCommitWork.js
index e58ecf95e087..5002942ab352 100644
--- a/packages/react-reconciler/src/ReactFiberCommitWork.js
+++ b/packages/react-reconciler/src/ReactFiberCommitWork.js
@@ -2391,12 +2391,9 @@ function getRetryCache(finishedWork: Fiber) {
     }
     case OffscreenComponent: {
       const instance: OffscreenInstance = finishedWork.stateNode;
-      // $FlowFixMe[incompatible-type-arg] found when upgrading Flow
       let retryCache: null | Set<Wakeable> | WeakSet<Wakeable> =
-        // $FlowFixMe[incompatible-type] found when upgrading Flow
         instance._retryCache;
       if (retryCache === null) {
-        // $FlowFixMe[incompatible-type]
         retryCache = instance._retryCache = new PossiblyWeakSet();
       }
       return retryCache;
diff --git a/packages/react-reconciler/src/ReactFiberContext.js b/packages/react-reconciler/src/ReactFiberContext.js
index 264e39f05666..06479e7e91cd 100644
--- a/packages/react-reconciler/src/ReactFiberContext.js
+++ b/packages/react-reconciler/src/ReactFiberContext.js
@@ -24,7 +24,6 @@ if (__DEV__) {
   warnedAboutMissingGetChildContext = ({}: {[string]: boolean});
 }
 
-// $FlowFixMe[incompatible-exact]
 export const emptyContextObject: {} = {};
 if (__DEV__) {
   Object.freeze(emptyContextObject);
diff --git a/packages/react-reconciler/src/ReactFiberHooks.js b/packages/react-reconciler/src/ReactFiberHooks.js
index 53d726aeb2d8..33ea6cd6ef94 100644
--- a/packages/react-reconciler/src/ReactFiberHooks.js
+++ b/packages/react-reconciler/src/ReactFiberHooks.js
@@ -2806,7 +2806,6 @@ const HooksDispatcherOnMount: Dispatcher = {
   useId: mountId,
 };
 if (enableCache) {
-  // $FlowFixMe[escaped-generic] discovered when updating Flow
   (HooksDispatcherOnMount: Dispatcher).useCacheRefresh = mountRefresh;
 }
 if (enableUseHook) {
diff --git a/packages/react-reconciler/src/ReactFiberOffscreenComponent.js b/packages/react-reconciler/src/ReactFiberOffscreenComponent.js
index d8833779195d..2f628d41ee50 100644
--- a/packages/react-reconciler/src/ReactFiberOffscreenComponent.js
+++ b/packages/react-reconciler/src/ReactFiberOffscreenComponent.js
@@ -54,7 +54,6 @@ export type OffscreenInstance = {
   _visibility: OffscreenVisibility,
   _pendingMarkers: Set<TracingMarkerInstance> | null,
   _transitions: Set<Transition> | null,
-  // $FlowFixMe[incompatible-type-arg] found when upgrading Flow
   _retryCache: WeakSet<Wakeable> | Set<Wakeable> | null,
 
   // Represents the current Offscreen fiber
diff --git a/packages/react-reconciler/src/ReactFiberWorkLoop.js b/packages/react-reconciler/src/ReactFiberWorkLoop.js
index 264d497d8f7e..7009380c1d96 100644
--- a/packages/react-reconciler/src/ReactFiberWorkLoop.js
+++ b/packages/react-reconciler/src/ReactFiberWorkLoop.js
@@ -1813,7 +1813,6 @@ function handleThrow(root: FiberRoot, thrownValue: any): void {
     const isWakeable =
       thrownValue !== null &&
       typeof thrownValue === 'object' &&
-      // $FlowFixMe[method-unbinding]
       typeof thrownValue.then === 'function';
 
     workInProgressSuspendedReason = isWakeable
@@ -3458,7 +3457,6 @@ export function resolveRetryWakeable(boundaryFiber: Fiber, wakeable: Wakeable) {
       break;
     case OffscreenComponent: {
       const instance: OffscreenInstance = boundaryFiber.stateNode;
-      // $FlowFixMe[incompatible-type] found when upgrading Flow
       retryCache = instance._retryCache;
       break;
     }
diff --git a/packages/react-refresh/src/ReactFreshRuntime.js b/packages/react-refresh/src/ReactFreshRuntime.js
index 68f0e6281e4c..aff061937292 100644
--- a/packages/react-refresh/src/ReactFreshRuntime.js
+++ b/packages/react-refresh/src/ReactFreshRuntime.js
@@ -50,8 +50,9 @@ const allFamiliesByID: Map<string, Family> = new Map();
 const allFamiliesByType:
   | WeakMap<any, Family>
   | Map<any, Family> = new PossiblyWeakMap();
-const allSignaturesByType: // $FlowFixMe
-WeakMap<any, Signature> | Map<any, Signature> = new PossiblyWeakMap();
+const allSignaturesByType:
+  | WeakMap<any, Signature>
+  | Map<any, Signature> = new PossiblyWeakMap();
 // This WeakMap is read by React, so we only put families
 // that have actually been edited here. This keeps checks fast.
 const updatedFamiliesByType:
diff --git a/packages/react-server/src/ReactFizzContext.js b/packages/react-server/src/ReactFizzContext.js
index 48e2e20c3217..f3e9022b8ba6 100644
--- a/packages/react-server/src/ReactFizzContext.js
+++ b/packages/react-server/src/ReactFizzContext.js
@@ -17,7 +17,6 @@ if (__DEV__) {
   warnedAboutMissingGetChildContext = ({}: {[string]: boolean});
 }
 
-// $FlowFixMe[incompatible-exact]
 export const emptyContextObject: {} = {};
 if (__DEV__) {
   Object.freeze(emptyContextObject);
diff --git a/packages/react-server/src/ReactFlightCache.js b/packages/react-server/src/ReactFlightCache.js
index 20e5075118b6..7ac8aaa66222 100644
--- a/packages/react-server/src/ReactFlightCache.js
+++ b/packages/react-server/src/ReactFlightCache.js
@@ -36,7 +36,6 @@ export const DefaultCacheDispatcher: CacheDispatcher = {
     let entry: AbortSignal | void = (cache.get(createSignal): any);
     if (entry === undefined) {
       entry = createSignal();
-      // $FlowFixMe[incompatible-use] found when upgrading Flow
       cache.set(createSignal, entry);
     }
     return entry;
@@ -47,7 +46,6 @@ export const DefaultCacheDispatcher: CacheDispatcher = {
     if (entry === undefined) {
       entry = resourceType();
       // TODO: Warn if undefined?
-      // $FlowFixMe[incompatible-use] found when upgrading Flow
       cache.set(resourceType, entry);
     }
     return entry;
diff --git a/packages/react-server/src/ReactFlightServer.js b/packages/react-server/src/ReactFlightServer.js
index acaece554141..548a7f5252d2 100644
--- a/packages/react-server/src/ReactFlightServer.js
+++ b/packages/react-server/src/ReactFlightServer.js
@@ -1006,7 +1006,6 @@ export function resolveModelToJSON(
     return serializeByValueID(symbolId);
   }
 
-  // $FlowFixMe: bigint isn't added to Flow yet.
   if (typeof value === 'bigint') {
     throw new Error(
       `BigInt (${value}) is not yet supported in Client Component props.` +
diff --git a/packages/react-server/src/ReactServerStreamConfigBun.js b/packages/react-server/src/ReactServerStreamConfigBun.js
index fd90c17a3d1e..addbd5111325 100644
--- a/packages/react-server/src/ReactServerStreamConfigBun.js
+++ b/packages/react-server/src/ReactServerStreamConfigBun.js
@@ -71,7 +71,6 @@ export function clonePrecomputedChunk(
 }
 
 export function closeWithError(destination: Destination, error: mixed): void {
-  // $FlowFixMe[method-unbinding]
   if (typeof destination.error === 'function') {
     // $FlowFixMe: This is an Error object or the destination accepts other types.
     destination.error(error);
diff --git a/packages/react/src/ReactDebugCurrentFrame.js b/packages/react/src/ReactDebugCurrentFrame.js
index a29ec8c93e29..4be7e22cd2f7 100644
--- a/packages/react/src/ReactDebugCurrentFrame.js
+++ b/packages/react/src/ReactDebugCurrentFrame.js
@@ -11,9 +11,7 @@ const ReactDebugCurrentFrame: {
   setExtraStackFrame?: (stack: null | string) => void,
   getCurrentStack?: null | (() => string),
   getStackAddendum?: () => string,
-} =
-  // $FlowFixMe[incompatible-exact]
-  {};
+} = {};
 
 let currentExtraStackFrame = (null: null | string);