diff --git a/package.json b/package.json
index 7e9b35f00beea..00a3a5e67df68 100644
--- a/package.json
+++ b/package.json
@@ -97,6 +97,7 @@
     "through2": "^3.0.1",
     "tmp": "^0.1.0",
     "typescript": "^3.7.5",
+    "undici": "^5.28.4",
     "web-streams-polyfill": "^3.1.1",
     "yargs": "^15.3.1"
   },
diff --git a/packages/react-client/src/ReactFlightReplyClient.js b/packages/react-client/src/ReactFlightReplyClient.js
index eb562dd7b23c9..b54f6e4edb0f5 100644
--- a/packages/react-client/src/ReactFlightReplyClient.js
+++ b/packages/react-client/src/ReactFlightReplyClient.js
@@ -187,9 +187,17 @@ export function processReply(
 
   function serializeTypedArray(
     tag: string,
-    typedArray: ArrayBuffer | $ArrayBufferView,
+    typedArray: $ArrayBufferView,
   ): string {
-    const blob = new Blob([typedArray]);
+    const blob = new Blob([
+      // We should be able to pass the buffer straight through but Node < 18 treat
+      // multi-byte array blobs differently so we first convert it to single-byte.
+      new Uint8Array(
+        typedArray.buffer,
+        typedArray.byteOffset,
+        typedArray.byteLength,
+      ),
+    ]);
     const blobId = nextPartId++;
     if (formData === null) {
       formData = new FormData();
@@ -392,7 +400,13 @@ export function processReply(
 
       if (enableBinaryFlight) {
         if (value instanceof ArrayBuffer) {
-          return serializeTypedArray('A', value);
+          const blob = new Blob([value]);
+          const blobId = nextPartId++;
+          if (formData === null) {
+            formData = new FormData();
+          }
+          formData.append(formFieldPrefix + blobId, blob);
+          return '$' + 'A' + blobId.toString(16);
         }
         if (value instanceof Int8Array) {
           // char
diff --git a/packages/react-client/src/__tests__/ReactFlight-test.js b/packages/react-client/src/__tests__/ReactFlight-test.js
index 7071ef5081542..a2e4d7af2953d 100644
--- a/packages/react-client/src/__tests__/ReactFlight-test.js
+++ b/packages/react-client/src/__tests__/ReactFlight-test.js
@@ -10,6 +10,14 @@
 
 'use strict';
 
+if (typeof Blob === 'undefined') {
+  global.Blob = require('buffer').Blob;
+}
+if (typeof File === 'undefined' || typeof FormData === 'undefined') {
+  global.File = require('undici').File;
+  global.FormData = require('undici').FormData;
+}
+
 function normalizeCodeLocInfo(str) {
   return (
     str &&
@@ -513,39 +521,37 @@ describe('ReactFlight', () => {
       `);
   });
 
-  if (typeof FormData !== 'undefined') {
-    it('can transport FormData (no blobs)', async () => {
-      function ComponentClient({prop}) {
-        return `
-          formData: ${prop instanceof FormData}
-          hi: ${prop.get('hi')}
-          multiple: ${prop.getAll('multiple')}
-          content: ${JSON.stringify(Array.from(prop))}
-        `;
-      }
-      const Component = clientReference(ComponentClient);
-
-      const formData = new FormData();
-      formData.append('hi', 'world');
-      formData.append('multiple', 1);
-      formData.append('multiple', 2);
+  it('can transport FormData (no blobs)', async () => {
+    function ComponentClient({prop}) {
+      return `
+        formData: ${prop instanceof FormData}
+        hi: ${prop.get('hi')}
+        multiple: ${prop.getAll('multiple')}
+        content: ${JSON.stringify(Array.from(prop))}
+      `;
+    }
+    const Component = clientReference(ComponentClient);
 
-      const model = <Component prop={formData} />;
+    const formData = new FormData();
+    formData.append('hi', 'world');
+    formData.append('multiple', 1);
+    formData.append('multiple', 2);
 
-      const transport = ReactNoopFlightServer.render(model);
+    const model = <Component prop={formData} />;
 
-      await act(async () => {
-        ReactNoop.render(await ReactNoopFlightClient.read(transport));
-      });
+    const transport = ReactNoopFlightServer.render(model);
 
-      expect(ReactNoop).toMatchRenderedOutput(`
-          formData: true
-          hi: world
-          multiple: 1,2
-          content: [["hi","world"],["multiple","1"],["multiple","2"]]
-        `);
+    await act(async () => {
+      ReactNoop.render(await ReactNoopFlightClient.read(transport));
     });
-  }
+
+    expect(ReactNoop).toMatchRenderedOutput(`
+        formData: true
+        hi: world
+        multiple: 1,2
+        content: [["hi","world"],["multiple","1"],["multiple","2"]]
+      `);
+  });
 
   it('can transport cyclic objects', async () => {
     function ComponentClient({prop}) {
diff --git a/packages/react-server-dom-webpack/src/__tests__/ReactFlightDOMEdge-test.js b/packages/react-server-dom-webpack/src/__tests__/ReactFlightDOMEdge-test.js
index 6e2e02047bbe6..87a5266dee079 100644
--- a/packages/react-server-dom-webpack/src/__tests__/ReactFlightDOMEdge-test.js
+++ b/packages/react-server-dom-webpack/src/__tests__/ReactFlightDOMEdge-test.js
@@ -15,11 +15,10 @@ global.ReadableStream =
   require('web-streams-polyfill/ponyfill/es6').ReadableStream;
 global.TextEncoder = require('util').TextEncoder;
 global.TextDecoder = require('util').TextDecoder;
-if (typeof Blob === 'undefined') {
-  global.Blob = require('buffer').Blob;
-}
-if (typeof File === 'undefined') {
-  global.File = require('buffer').File;
+global.Blob = require('buffer').Blob;
+if (typeof File === 'undefined' || typeof FormData === 'undefined') {
+  global.File = require('buffer').File || require('undici').File;
+  global.FormData = require('undici').FormData;
 }
 
 // Don't wait before processing work on the server.
@@ -379,45 +378,40 @@ describe('ReactFlightDOMEdge', () => {
     expect(await result.arrayBuffer()).toEqual(await blob.arrayBuffer());
   });
 
-  if (typeof FormData !== 'undefined' && typeof File !== 'undefined') {
-    // @gate enableBinaryFlight
-    it('can transport FormData (blobs)', async () => {
-      const bytes = new Uint8Array([
-        123, 4, 10, 5, 100, 255, 244, 45, 56, 67, 43, 124, 67, 89, 100, 20,
-      ]);
-      const blob = new Blob([bytes, bytes], {
-        type: 'application/x-test',
-      });
-
-      const formData = new FormData();
-      formData.append('hi', 'world');
-      formData.append('file', blob, 'filename.test');
-
-      expect(formData.get('file') instanceof File).toBe(true);
-      expect(formData.get('file').name).toBe('filename.test');
-
-      const stream = passThrough(
-        ReactServerDOMServer.renderToReadableStream(formData),
-      );
-      const result = await ReactServerDOMClient.createFromReadableStream(
-        stream,
-        {
-          ssrManifest: {
-            moduleMap: null,
-            moduleLoading: null,
-          },
-        },
-      );
-
-      expect(result instanceof FormData).toBe(true);
-      expect(result.get('hi')).toBe('world');
-      const resultBlob = result.get('file');
-      expect(resultBlob instanceof Blob).toBe(true);
-      expect(resultBlob.name).toBe('blob'); // We should not pass through the file name for security.
-      expect(resultBlob.size).toBe(bytes.length * 2);
-      expect(await resultBlob.arrayBuffer()).toEqual(await blob.arrayBuffer());
+  // @gate enableBinaryFlight
+  it('can transport FormData (blobs)', async () => {
+    const bytes = new Uint8Array([
+      123, 4, 10, 5, 100, 255, 244, 45, 56, 67, 43, 124, 67, 89, 100, 20,
+    ]);
+    const blob = new Blob([bytes, bytes], {
+      type: 'application/x-test',
     });
-  }
+
+    const formData = new FormData();
+    formData.append('hi', 'world');
+    formData.append('file', blob, 'filename.test');
+
+    expect(formData.get('file') instanceof File).toBe(true);
+    expect(formData.get('file').name).toBe('filename.test');
+
+    const stream = passThrough(
+      ReactServerDOMServer.renderToReadableStream(formData),
+    );
+    const result = await ReactServerDOMClient.createFromReadableStream(stream, {
+      ssrManifest: {
+        moduleMap: null,
+        moduleLoading: null,
+      },
+    });
+
+    expect(result instanceof FormData).toBe(true);
+    expect(result.get('hi')).toBe('world');
+    const resultBlob = result.get('file');
+    expect(resultBlob instanceof Blob).toBe(true);
+    expect(resultBlob.name).toBe('blob'); // We should not pass through the file name for security.
+    expect(resultBlob.size).toBe(bytes.length * 2);
+    expect(await resultBlob.arrayBuffer()).toEqual(await blob.arrayBuffer());
+  });
 
   it('can pass an async import that resolves later to an outline object like a Map', async () => {
     let resolve;
diff --git a/packages/react-server-dom-webpack/src/__tests__/ReactFlightDOMReplyEdge-test.js b/packages/react-server-dom-webpack/src/__tests__/ReactFlightDOMReplyEdge-test.js
index 00a53a590c5e1..ab0d54c0bc0f3 100644
--- a/packages/react-server-dom-webpack/src/__tests__/ReactFlightDOMReplyEdge-test.js
+++ b/packages/react-server-dom-webpack/src/__tests__/ReactFlightDOMReplyEdge-test.js
@@ -16,11 +16,10 @@ global.ReadableStream =
 global.TextEncoder = require('util').TextEncoder;
 global.TextDecoder = require('util').TextDecoder;
 
-if (typeof Blob === 'undefined') {
-  global.Blob = require('buffer').Blob;
-}
-if (typeof File === 'undefined') {
-  global.File = require('buffer').File;
+global.Blob = require('buffer').Blob;
+if (typeof File === 'undefined' || typeof FormData === 'undefined') {
+  global.File = require('buffer').File || require('undici').File;
+  global.FormData = require('undici').FormData;
 }
 
 // let serverExports;
@@ -44,13 +43,6 @@ describe('ReactFlightDOMReplyEdge', () => {
     ReactServerDOMClient = require('react-server-dom-webpack/client.edge');
   });
 
-  if (typeof FormData === 'undefined') {
-    // We can't test if we don't have a native FormData implementation because the JSDOM one
-    // is missing the arrayBuffer() method.
-    it('cannot test', () => {});
-    return;
-  }
-
   it('can encode a reply', async () => {
     const body = await ReactServerDOMClient.encodeReply({some: 'object'});
     const decoded = await ReactServerDOMServer.decodeReply(
@@ -89,6 +81,8 @@ describe('ReactFlightDOMReplyEdge', () => {
     );
 
     expect(result).toEqual(buffers);
+    // Array buffers can't use the toEqual helper.
+    expect(new Uint8Array(result[0])).toEqual(new Uint8Array(buffers[0]));
   });
 
   // @gate enableBinaryFlight
@@ -109,35 +103,33 @@ describe('ReactFlightDOMReplyEdge', () => {
     expect(await result.arrayBuffer()).toEqual(await blob.arrayBuffer());
   });
 
-  if (typeof FormData !== 'undefined' && typeof File !== 'undefined') {
-    it('can transport FormData (blobs)', async () => {
-      const bytes = new Uint8Array([
-        123, 4, 10, 5, 100, 255, 244, 45, 56, 67, 43, 124, 67, 89, 100, 20,
-      ]);
-      const blob = new Blob([bytes, bytes], {
-        type: 'application/x-test',
-      });
-
-      const formData = new FormData();
-      formData.append('hi', 'world');
-      formData.append('file', blob, 'filename.test');
-
-      expect(formData.get('file') instanceof File).toBe(true);
-      expect(formData.get('file').name).toBe('filename.test');
-
-      const body = await ReactServerDOMClient.encodeReply(formData);
-      const result = await ReactServerDOMServer.decodeReply(
-        body,
-        webpackServerMap,
-      );
-
-      expect(result instanceof FormData).toBe(true);
-      expect(result.get('hi')).toBe('world');
-      const resultBlob = result.get('file');
-      expect(resultBlob instanceof Blob).toBe(true);
-      expect(resultBlob.name).toBe('filename.test'); // In this direction we allow file name to pass through but not other direction.
-      expect(resultBlob.size).toBe(bytes.length * 2);
-      expect(await resultBlob.arrayBuffer()).toEqual(await blob.arrayBuffer());
+  it('can transport FormData (blobs)', async () => {
+    const bytes = new Uint8Array([
+      123, 4, 10, 5, 100, 255, 244, 45, 56, 67, 43, 124, 67, 89, 100, 20,
+    ]);
+    const blob = new Blob([bytes, bytes], {
+      type: 'application/x-test',
     });
-  }
+
+    const formData = new FormData();
+    formData.append('hi', 'world');
+    formData.append('file', blob, 'filename.test');
+
+    expect(formData.get('file') instanceof File).toBe(true);
+    expect(formData.get('file').name).toBe('filename.test');
+
+    const body = await ReactServerDOMClient.encodeReply(formData);
+    const result = await ReactServerDOMServer.decodeReply(
+      body,
+      webpackServerMap,
+    );
+
+    expect(result instanceof FormData).toBe(true);
+    expect(result.get('hi')).toBe('world');
+    const resultBlob = result.get('file');
+    expect(resultBlob instanceof Blob).toBe(true);
+    expect(resultBlob.name).toBe('filename.test'); // In this direction we allow file name to pass through but not other direction.
+    expect(resultBlob.size).toBe(bytes.length * 2);
+    expect(await resultBlob.arrayBuffer()).toEqual(await blob.arrayBuffer());
+  });
 });
diff --git a/yarn.lock b/yarn.lock
index b68244928f09d..e56d08d371ca0 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -2182,6 +2182,11 @@
   resolved "https://registry.yarnpkg.com/@eslint/js/-/js-9.0.0.tgz#1a9e4b4c96d8c7886e0110ed310a0135144a1691"
   integrity sha512-RThY/MnKrhubF6+s1JflwUjPEsnCEmYCWwqa/aRISKWNXGZ9epUwft4bUMM35SdKF9xvBrLydAM1RDHd1Z//ZQ==
 
+"@fastify/busboy@^2.0.0":
+  version "2.1.1"
+  resolved "https://registry.yarnpkg.com/@fastify/busboy/-/busboy-2.1.1.tgz#b9da6a878a371829a0502c9b6c1c143ef6663f4d"
+  integrity sha512-vBZP4NlzfOlerQTnba4aqZoMhE/a9HY7HRqoOPaETQcSQuWEIyZMHGfVu6w9wGtGK5fED5qRs2DteVCjOH60sA==
+
 "@gitbeaker/core@^21.7.0":
   version "21.7.0"
   resolved "https://registry.yarnpkg.com/@gitbeaker/core/-/core-21.7.0.tgz#fcf7a12915d39f416e3f316d0a447a814179b8e5"
@@ -15762,6 +15767,13 @@ unc-path-regex@^0.1.0, unc-path-regex@^0.1.2:
   resolved "https://registry.yarnpkg.com/unc-path-regex/-/unc-path-regex-0.1.2.tgz#e73dd3d7b0d7c5ed86fbac6b0ae7d8c6a69d50fa"
   integrity sha1-5z3T17DXxe2G+6xrCufYxqadUPo=
 
+undici@^5.28.4:
+  version "5.28.4"
+  resolved "https://registry.yarnpkg.com/undici/-/undici-5.28.4.tgz#6b280408edb6a1a604a9b20340f45b422e373068"
+  integrity sha512-72RFADWFqKmUb2hmmvNODKL3p9hcB6Gt2DOQMis1SEBaV6a4MH8soBvzg+95CYhCKPFedut2JY9bMfrDl9D23g==
+  dependencies:
+    "@fastify/busboy" "^2.0.0"
+
 unicode-canonical-property-names-ecmascript@^1.0.4:
   version "1.0.4"
   resolved "https://registry.yarnpkg.com/unicode-canonical-property-names-ecmascript/-/unicode-canonical-property-names-ecmascript-1.0.4.tgz#2619800c4c825800efdd8343af7dd9933cbe2818"