Solution to make AdiIRC interface with screen readers.
Latest Preconfigured Adispeak
Get adispeak alpha 0.2.1 from: https://www.sendspace.com/pro/dl/bmw9g0
Put everything in adispeak\bin\x64\release into the same folder as AdiIRC.exe. Run AdiIRC.exe, go to file, plugins, then load. Load adispeak.dll. It should work!
Have Visual Studio 2017. Do the obvious things; the project should come with everything you need!