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Incorrect external neighbors when using reverse complements #9
For a genotype g_1 in a genotype set G_1, all 1-mutants of g_1 that do not lie in G_1, a.k.a external neighbors, are generated for several different analyses. The generation/computation of such 1-mutants is at present not correct when the '-rc' flag is used.
A correct implementation is required for accurate results of analyses like Evolvability, Accessibility, Neighbor abundance, Diversity index, etc.
The following holds true only when reverse complements are considered, which is currently only possible when working with DNA genotypes.
Then when generating external neighbors for all genotypes in
The impact of this change is higher on genotype level results, but minimal on genotype set level results.