diff --git a/devel/py-typeguard/Makefile b/devel/py-typeguard/Makefile
index 7080041c841c4..9b0ede4e03143 100644
--- a/devel/py-typeguard/Makefile
+++ b/devel/py-typeguard/Makefile
@@ -1,5 +1,5 @@
 PORTNAME=	typeguard
-PORTVERSION=	4.0.0
+PORTVERSION=	4.1.0
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
@@ -11,7 +11,7 @@ WWW=		https://github.com/agronholm/typeguard
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BUILD_DEPENDS=	${PY_SETUPTOOLS} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools>=61:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools_scm>=6.4:devel/py-setuptools_scm@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}mypy>=0.991:devel/py-mypy@${PY_FLAVOR} \
@@ -28,8 +28,8 @@ NO_ARCH=	yes
 RUN_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}importlib-metadata>=3.6:devel/py-importlib-metadata@${PY_FLAVOR}
 .endif
 
-.if ${PYTHON_REL} < 31100
-RUN_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}typing-extensions>=4.4.0:devel/py-typing-extensions@${PY_FLAVOR}
+.if ${PYTHON_REL} < 31200
+RUN_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}typing-extensions>=4.7.0:devel/py-typing-extensions@${PY_FLAVOR}
 .endif
 
 .include <bsd.port.post.mk>
diff --git a/devel/py-typeguard/distinfo b/devel/py-typeguard/distinfo
index 29b07a141fc2a..2c04587ddfce6 100644
--- a/devel/py-typeguard/distinfo
+++ b/devel/py-typeguard/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1685162198
-SHA256 (typeguard-4.0.0.tar.gz) = 194fb3dbcb06ea9caf7088f3befee014de57961689f9c859ac5239b1ef61d987
-SIZE (typeguard-4.0.0.tar.gz) = 66064
+TIMESTAMP = 1691070124
+SHA256 (typeguard-4.1.0.tar.gz) = b05a54bb0276eefd28880df42e004a71e699c8081fcb9d0536b2ceb01019f60c
+SIZE (typeguard-4.1.0.tar.gz) = 67584