diff --git a/graphics/simpleitk/Makefile b/graphics/simpleitk/Makefile
index 7618936eabe7f..3a4c59c3c06c8 100644
--- a/graphics/simpleitk/Makefile
+++ b/graphics/simpleitk/Makefile
@@ -1,6 +1,6 @@
 PORTNAME=	simpleitk
 DISTVERSIONPREFIX=	v
-DISTVERSION=	2.2.0
+DISTVERSION=	2.2.1
 CATEGORIES=	graphics
 
 MAINTAINER=	yuri@FreeBSD.org
@@ -15,7 +15,8 @@ BROKEN_i386=	clang consistently runs out of memory
 
 LIB_DEPENDS=	libgdcmCommon.so:devel/gdcm \
 		libhdf5.so:science/hdf5 \
-		libITKCommon-${ITK_VER}.so:science/InsightToolkit
+		libITKCommon-${ITK_VER}.so:science/InsightToolkit \
+		libvnl.so:misc/vxl
 TEST_DEPENDS=	googletest>0:devel/googletest
 
 USES=		cmake:testing compiler:c++14-lang eigen:3 lua:53 # tests fail to configure due to GTest::GTest related issues, see also https://github.com/SimpleITK/SimpleITK/issues/1765
@@ -29,10 +30,12 @@ CMAKE_OFF=	WRAP_DEFAULT
 CMAKE_OFF+=	BUILD_TESTING BUILD_EXAMPLES
 CMAKE_ON=	BUILD_SHARED_LIBS
 CMAKE_ARGS=	-DSimpleITK_LUA_EXECUTABLE=${LUA_CMD}
-CMAKE_TESTING_ON=	BUILD_TESTING
+CMAKE_TESTING_ON=	BUILD_TESTING # tests fail to find GTest, see https://github.com/SimpleITK/SimpleITK/issues/1807
 
 PLIST_SUB+=	VER=${DISTVERSION:R}
 
+BINARY_ALIAS=	git=false
+
 post-install: # remove contentless docs
 	@${RM} -r ${STAGEDIR}${PREFIX}/share
 
diff --git a/graphics/simpleitk/distinfo b/graphics/simpleitk/distinfo
index 1dc51c054bec1..12930eea68b1f 100644
--- a/graphics/simpleitk/distinfo
+++ b/graphics/simpleitk/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1668670217
-SHA256 (SimpleITK-SimpleITK-v2.2.0_GH0.tar.gz) = b3ba80062de5c52fe01e4f9e17aa02f287b06882874a68d91ef2fb5d101df67a
-SIZE (SimpleITK-SimpleITK-v2.2.0_GH0.tar.gz) = 1991146
+TIMESTAMP = 1672904277
+SHA256 (SimpleITK-SimpleITK-v2.2.1_GH0.tar.gz) = 4e2e15c5fa47b31bdec591f8c7987b489648a13bef402696da1b7da94b425843
+SIZE (SimpleITK-SimpleITK-v2.2.1_GH0.tar.gz) = 1991560