diff --git a/archivers/py-blosc2/Makefile b/archivers/py-blosc2/Makefile
index b1ee988a5621d..dd28d2b6d891f 100644
--- a/archivers/py-blosc2/Makefile
+++ b/archivers/py-blosc2/Makefile
@@ -1,5 +1,5 @@
 PORTNAME=	blosc2
-PORTVERSION=	2.2.5
+PORTVERSION=	2.2.6
 CATEGORIES=	archivers python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
@@ -11,12 +11,12 @@ WWW=		https://github.com/Blosc/python-blosc2
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
-BUILD_DEPENDS=	c-blosc2>=2.10.0:archivers/c-blosc2 \
+BUILD_DEPENDS=	c-blosc2>=2.10.1:archivers/c-blosc2 \
 		cmake:devel/cmake-core \
 		ninja:devel/ninja \
 		${PYTHON_PKGNAMEPREFIX}numpy>=0,1:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scikit-build>=0:devel/py-scikit-build@${PY_FLAVOR} \
-		${PY_SETUPTOOLS}
+		${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR}
 LIB_DEPENDS=	libblosc2.so:archivers/c-blosc2
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}msgpack>=0:devel/py-msgpack@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}ndindex>=1.4:math/py-ndindex@${PY_FLAVOR} \
diff --git a/archivers/py-blosc2/distinfo b/archivers/py-blosc2/distinfo
index 54949acf7c759..f03bc9381915f 100644
--- a/archivers/py-blosc2/distinfo
+++ b/archivers/py-blosc2/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1688902019
-SHA256 (blosc2-2.2.5.tar.gz) = b8c0940267dd8df7a2b95ee2a3701ded2d240c85b27514909d9997425a091f54
-SIZE (blosc2-2.2.5.tar.gz) = 4653447
+TIMESTAMP = 1691069954
+SHA256 (blosc2-2.2.6.tar.gz) = e388e7160075376789542e7b23a08d1a0292f34532fb582f3c610b4ccf80d8f0
+SIZE (blosc2-2.2.6.tar.gz) = 4656129
diff --git a/archivers/py-blosc2/files/patch-pyproject.toml b/archivers/py-blosc2/files/patch-pyproject.toml
index d330ef2ac941d..0a4c70f8ad95c 100644
--- a/archivers/py-blosc2/files/patch-pyproject.toml
+++ b/archivers/py-blosc2/files/patch-pyproject.toml
@@ -2,8 +2,8 @@
 +++ pyproject.toml
 @@ -1,5 +1,5 @@
  [build-system]
--requires = ["setuptools", "scikit-build", "cython", "cmake", "ninja", "oldest-supported-numpy"]
-+requires = ["setuptools", "scikit-build", "cython", "numpy"]
+-requires = ["setuptools", "scikit-build", "cython<3", "cmake", "ninja", "oldest-supported-numpy"]
++requires = ["setuptools", "scikit-build", "cython<3", "numpy"]
  
  [project]
  name = "blosc2"