Python and OpenSSL Versions
Freshdesk API supports only TLS 1.1 and 1.2. TLS 1.0 has been deprecated since November 30, 2016.
Ensure that your Python and Openssl Supports the correct versions. To check which openssl version you are using execute the following within python
import ssl print ssl.OPENSSL_VERSION
To have support for the higher versions you need OpenSSL version 1.0.2 or 1.0.1. If you have only 1.0.0 or 0.9.8 you need to upgrade your python+OpenSSL. Please look into this Stack Overflow thread for more information