diff --git a/src/FSharpPlus/Control/Applicative.fs b/src/FSharpPlus/Control/Applicative.fs
index 400a3cef6..fc99c33eb 100644
--- a/src/FSharpPlus/Control/Applicative.fs
+++ b/src/FSharpPlus/Control/Applicative.fs
@@ -143,21 +143,92 @@ type Lift3 with
     static member inline Lift3 (_, (_:'t when 't: null and 't: struct, _: ^u when ^u : null and ^u: struct, _: ^v when ^v : null and ^v: struct), _mthd: Default1) = id
     static member inline Lift3 (f: 'T -> 'U -> 'V -> 'W, (x: '``Applicative<'T>``, y: '``Applicative<'U>``, z: '``Applicative<'V>``)            , _mthd: Default1) = ((^``Applicative<'T>`` or ^``Applicative<'U>`` or ^``Applicative<'V>`` ) : (static member Lift3 : _*_*_*_ -> _) f, x, y, z)
 
+type IsLeftZeroHelper =
+    static member Seq (xs: seq<'t>) = Seq.isEmpty xs
+    static member NonEmptySeq (_: NonEmptySeq<'t>) = false
+    static member List (xs: list<'t>) = List.isEmpty xs
+    static member Array (xs: array<'t>) = Array.isEmpty xs
+    static member Option (x: option<'t>) = Option.isNone x
+    static member Result (x: Result<'t, 'u>) = match x with Error _ -> true | _ -> false
+    static member Choice (x: Choice<'t, 'u>) = match x with Choice2Of2 _ -> true | _ -> false
+
+#if !FABLE_COMPILER
+type IsLeftZeroHelper<'a>() =
+    /// turns false if
+    /// - it should always return false because neither `IsLeftZero` nor `Empty` are present
+    /// - the target method is inlined and cannot be called through reflection
+    static let mutable isValid = true
+
+    static let isLeftZero =
+        let ty = typeof<'a>
+        let check typedef = ty.IsGenericType && (ty.GetGenericTypeDefinition() = typedef)
+        let helperTy = typeof<IsLeftZeroHelper>
+        let helper helperName tprms : 'a -> bool =
+            let meth = helperTy.GetMethod(helperName).MakeGenericMethod(tprms)
+            fun x -> meth.Invoke(null, [|box x|]) |> unbox
+        let targs = ty.GetGenericArguments()
+        if check typedefof<seq<_>> then helper "Seq" targs
+        elif check typedefof<NonEmptySeq<_>> then helper "NonEmptySeq" targs
+        elif check typedefof<list<_>> then helper "List" targs
+        elif ty.IsArray then helper "Array" [| ty.GetElementType() |]
+        elif check typedefof<option<_>> then helper "Option" targs
+        elif check typedefof<Result<_, _>> then helper "Result" targs
+        elif check typedefof<Choice<_, _>> then helper "Choice" targs
+        else
+            let makeGeneric (mi: Reflection.MethodInfo) =
+                if Array.isEmpty targs || not mi.ContainsGenericParameters then mi
+                else mi.MakeGenericMethod(targs)
+            let isInlineError (e: Reflection.TargetInvocationException) =
+                match e.InnerException with
+                | :? NotSupportedException -> true
+                | _ -> false
+            let isLeftZero = ty.GetMethod("IsLeftZero")
+            if not (isNull isLeftZero) then
+                let isLeftZero = makeGeneric isLeftZero
+                (fun x ->
+                    try
+                       isLeftZero.Invoke(null, [| box x |]) |> unbox
+                    with
+                    | :? Reflection.TargetInvocationException as e when isInlineError e ->
+                        isValid <- false; false)
+            else
+                let fallback = fun _ -> false
+                let compareWith (obj: obj) = fun (x: 'a) -> obj.Equals(x)
+                try
+                    let emptyProp = ty.GetProperty("Empty")
+                    if not (isNull emptyProp) then emptyProp.GetValue(null) |> compareWith
+                    else
+                        let emptyMeth = ty.GetMethod("get_Empty", [||])
+                        if not (isNull emptyMeth) then
+                            let emptyMeth = makeGeneric emptyMeth
+                            emptyMeth.Invoke(null, [||]) |> compareWith
+                        else isValid <- false; fallback
+                with
+                | :? Reflection.TargetInvocationException as e when isInlineError e -> isValid <- false; fallback
+
+    static member Invoke(x: 'a) = isValid && isLeftZero x
+#endif
+
 type IsLeftZero =
     inherit Default1
 
-    static member IsLeftZero (t: ref<seq<_>>      , _mthd: IsLeftZero) = Seq.isEmpty t.Value
-    static member IsLeftZero (_: ref<NonEmptySeq<_>>, _mthd: IsLeftZero) = false
-    static member IsLeftZero (t: ref<list<_>>     , _mthd: IsLeftZero) = List.isEmpty t.Value
-    static member IsLeftZero (t: ref<array<_>>    , _mthd: IsLeftZero) = Array.isEmpty t.Value
-    static member IsLeftZero (t: ref<option<_>>   , _mthd: IsLeftZero) = Option.isNone t.Value
-    static member IsLeftZero (t: ref<Result<_,_>> , _mthd: IsLeftZero) = match t.Value with Error _      -> true | _ -> false
-    static member IsLeftZero (t: ref<Choice<_,_>> , _mthd: IsLeftZero) = match t.Value with Choice2Of2 _ -> true | _ -> false
+    static member IsLeftZero (t: ref<seq<_>>      , _mthd: IsLeftZero) = IsLeftZeroHelper.Seq t.Value
+    static member IsLeftZero (t: ref<NonEmptySeq<_>>, _mthd: IsLeftZero) = IsLeftZeroHelper.NonEmptySeq t.Value
+    static member IsLeftZero (t: ref<list<_>>     , _mthd: IsLeftZero) = IsLeftZeroHelper.List t.Value
+    static member IsLeftZero (t: ref<array<_>>    , _mthd: IsLeftZero) = IsLeftZeroHelper.Array t.Value
+    static member IsLeftZero (t: ref<option<_>>   , _mthd: IsLeftZero) = IsLeftZeroHelper.Option t.Value
+    static member IsLeftZero (t: ref<Result<_,_>> , _mthd: IsLeftZero) = IsLeftZeroHelper.Result t.Value
+    static member IsLeftZero (t: ref<Choice<_,_>> , _mthd: IsLeftZero) = IsLeftZeroHelper.Choice t.Value
 
+    #if !FABLE_COMPILER
+    static member        Invoke (x: '``Applicative<'T>``) : bool =
+        IsLeftZeroHelper<'``Applicative<'T>``>.Invoke(x)
+    #else
     static member inline Invoke (x: '``Applicative<'T>``) : bool =
         let inline call (mthd : ^M, input: ^I) =
             ((^M or ^I) : (static member IsLeftZero : _*_ -> _) ref input, mthd)
         call(Unchecked.defaultof<IsLeftZero>, x)
+    #endif
 
     static member inline InvokeOnInstance (x: '``Applicative<'T>``) : bool =
         ((^``Applicative<'T>``) : (static member IsLeftZero : _ -> _) x)
@@ -173,4 +244,4 @@ type IsLeftZero with
     static member inline IsLeftZero (t: ref<'``Applicative<'T>``>        , _mthd: Default1) = (^``Applicative<'T>`` : (static member IsLeftZero : _ -> _) t.Value)
     static member inline IsLeftZero (_: ref< ^t> when ^t: null and ^t: struct, _: Default1) = ()
 
-#endif
\ No newline at end of file
+#endif