# Known molecular discoveries — public review ledger **Status: LOOK LIVE — 2026-08-25 · PDB id Claim LIVE · occupancy DARK** **Program:** [Study 14 — Protein lattice](Study-14-Protein-Lattice-Manifold.md) · [Study 15 — Skala DFT shear](Study-15-Skala-DFT-Shear.md) · [Language-games study board](Language-Games-Study-Board.md) | Surface | URL | Grade | |---|---|---| | Catalog GET | https://affine.earth/language-game/discoveries/catalog.json | **LIVE** · `credentials: omit` · no visitor data | | IDE | https://affine.earth/language-game/ide.html#discovery-review | Template opens a fetched record | | Look walks | https://affine.earth/language-game/#researcher | GET links only. No auto-POST. | | Claim | `#pdb-holdings` 4HHB / 2HYY | **LIVE** on presented `pdb_id` · occupancy / residue / pocket stay **DARK** | The win is the **verified bond**, not custody of a fold and not a true/false “discovery” bit. --- ## For every reader — one paragraph A named public discovery here is a **fetched industry record** — a PDB accession in the hosted holdings, a PubChem CID, a ChEMBL id, a DailyMed SPL — walked Look → Claim → Build → Share. The cell serves the holdings index (N=258616) and a handful of fact sheets whose fields came from those fetches (4HHB, aspirin CID 2244 / CHEMBL25, DailyMed insulin human). Claim on a presented 4-char `pdb_id` is **LIVE**. Occupancy / residue / pocket stay DARK. The meaning of a WIN is holdings membership of that id, not a dock and not a cookbook. **Instructions** means cited public facts and links — INN, indication on the label, PDB / PubChem / ChEMBL / DailyMed id, manufacture *class* (recombinant / chemical / extracted) from FDA / EMA / label / PDB. It does **not** mean a synthesis cookbook. C-007: no pathogen enhancement, no military, no unpublished manufacture steps. **Using something that is not accurate (because it shears) may not be useless — it may be dangerous.** Skala / float MD / AlphaFold are the adversary on Study 14 / 15, not our method. --- ## Measured catalogs — 2026-08-24 (VERIFIED vs REPORTED) | Catalog | Number | Grade | Source · fetched | |---|---|---|---| | RCSB PDB current holdings | **258616** entry ids | **VERIFIED** | `GET https://data.rcsb.org/rest/v1/holdings/current/entry_ids` HTTP 200 · 2026-08-24T17:13:23Z · example id `1IWB` | | RCSB search `total_count` (experimental) | **258222** | **VERIFIED** | `POST https://search.rcsb.org/rcsbsearch/v2/query` HTTP 200 · example id `100D` | | Hosted index `index_n` | **258616** | **VERIFIED** (copy of the holdings fetch) | `/language-game/discoveries/catalog.json` | | ChEMBL distinct compounds | **2921148** | **VERIFIED** | [status.json](https://www.ebi.ac.uk/chembl/api/data/status.json) + `molecule.json` `page_meta.total_count` · ChEMBL_37 · 2026-05-01 · status UP | | ChEMBL compound records | **3824604** | **VERIFIED** | same status.json | | DailyMed SPL count `drug_name=aspirin` | **1077** | **VERIFIED** | `spls.json?drug_name=aspirin` HTTP 200 | | DailyMed SPL count `drug_name=insulin human` | **22** | **VERIFIED** | `spls.json?drug_name=insulin%20human` HTTP 200 | | PubChem compound universe | millions of CIDs | **REPORTED** (PUG listkey count HTTP 500 this hour) | Example **VERIFIED**: CID **2244** Aspirin `C9H8O4` | Do not collapse 258616 and 258222 into one invented number. Holdings is the index we host. Search `total_count` is a second instrument on a filtered query. --- ## One example record (fetched, not invented) **4HHB** — [RCSB](https://www.rcsb.org/structure/4HHB) · [REST](https://data.rcsb.org/rest/v1/core/entry/4HHB) HTTP 200 | Field | Value | Came from | |---|---|---| | id | `4HHB` | holdings + core entry | | name | THE CRYSTAL STRUCTURE OF HUMAN DEOXYHAEMOGLOBIN AT 1.74 ANGSTROMS RESOLUTION | `struct.title` | | method | X-RAY DIFFRACTION | `exptl[0].method` | | polymer_entity_count | 2 | `rcsb_entry_info` | | deposit_date | 1984-03-07 | `rcsb_accession_info` | | manufacture_class | none on this row | PDB is a structure archive, not a marketed-product label | **Aspirin** — PubChem CID 2244 · ChEMBL CHEMBL25 · DailyMed setid `ee8d0961-7572-471f-8c96-b4c0bd354de2` | Field | Value | Came from | |---|---|---| | INN | aspirin | PubChem Title / ChEMBL `pref_name` | | formula | C9H8O4 | PubChem | | IUPACName | 2-acetyloxybenzoic acid | PubChem | | molecule_type | Small molecule | ChEMBL_37 | | first_approval | 1950 | ChEMBL | | ATC | B01AC06 · N02BA01 · N02BA51 · A01AD05 | ChEMBL | | manufacture_class | chemical | ChEMBL small molecule + DailyMed tablet SPL. **Not** a synthesis recipe. | **Insulin human** — DailyMed setid `e245e0c5-b2d6-418b-baa4-1c3324292885` (HUMULIN 70/30, Eli Lilly) | Field | Value | Came from | |---|---|---| | INN | insulin human | DailyMed title | | manufacture_class | recombinant | Named product HUMULIN on the FDA/DailyMed listing. GET the SPL for the label text. **Not** a cookbook. | No IC50 is written on any row. If a number was not in the fetch, it is absent. --- ## How the four acts land here | Act | Researcher does | This surface | |---|---|---| | 1 LOOK | GET the catalog. No identity. | [catalog.json](https://affine.earth/language-game/discoveries/catalog.json) · [\#researcher](https://affine.earth/language-game/#researcher) | | 2 CLAIM | POST a presented PDB id + `source`+`role` | **LIVE** on `#pdb-holdings`. Occupancy / pocket stay **DARK**. Do not treat health dose as a pocket. | | 3 BUILD | Open the record in the IDE that exists | [ide.html#discovery-review](https://affine.earth/language-game/ide.html#discovery-review) | | 4 SHARE | GET view that names `source` | this page · catalog `examples[]` | `feeds_catalog` / `corpus_bonds` / `umc_*` already name transports. No new MCP tool. --- ## What this page does not do - Does not invent thousands of fake discovery rows - Does not write a synthesis cookbook - Does not land `ProteinManifold.evaluateDocking` or an O(1) dock - Does not claim folding, docking, or thermochemistry is solved - Does not call Skala / float MD / AlphaFold **useless** - Does not POST occupancy, residue, or pocket integers **Status: LOOK LIVE — hosted index N=258616. PDB id Claim LIVE. Occupancy DARK.** Family ledger: [Known discoveries](Known-Discoveries-Index.md). Play: [Study 14](Study-14-Protein-Lattice-Manifold.md) · IDE `#pdb-holdings`. Generated-candidate hashes (not this catalog): [protein-material-aggregates.json](https://affine.earth/language-game/discoveries/protein-material-aggregates.json) — Look only. Generated rows without a PDB/ICD/InChI/COD key are not playable.