pathway_id	pathway_label	reaction_id	reaction_label	enabler_complex_label	n_locations
R-HSA-1059683	Interleukin-6 signaling	R-HSA-1112602	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor	Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3	3
R-HSA-1059683	Interleukin-6 signaling	R-HSA-1112703	PTPN11 is phosphorylated	Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11	3
R-HSA-109704	PI3K Cascade	R-HSA-109699	PI3K-containing complexes phosphorylate PIP2 to PIP3	PI3K-containing complexes	4
R-HSA-112043	PLC beta mediated events	R-HSA-111879	PIP2 hydrolysis	Activated PLC beta 1/4	2
R-HSA-112043	PLC beta mediated events	R-HSA-169683	IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol	ITPR:I(1,4,5)P3 tetramer	2
R-HSA-112308	Presynaptic depolarization and calcium channel opening	R-HSA-210420	Ca2+ influx through voltage gated Ca2+ channels	Voltage Gated Ca2+ Channel	3
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-975311	HTR3 pentamer:5HT transports Na+,K+, and Ca2+	HTR3 pentamer:5HT	2
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-975389	GLRA:GLRB:Gly transports extracellular Cl- to cytosol	GLRA:GLRB:Gly	2
R-HSA-114516	Disinhibition of SNARE formation	R-HSA-114683	Phosphorylation of Platelet Sec-1	Activated conventional protein kinase C	2
R-HSA-114516	Disinhibition of SNARE formation	R-HSA-114684	Phosphorylation of Syntaxin-4	Activated conventional protein kinase C	2
R-HSA-114604	GPVI-mediated activation cascade	R-HSA-114600	Fyn/Lyn-mediated phosphorylation of FcR1 gamma	GPVI:FceRI gamma:FYN:LYN:Collagen type I	3
R-HSA-1169091	Activation of NF-kappaB in B cells	R-HSA-1168641	TAK1 associated with the CBM complex phosphorylates IKKbeta	p-CARMA1:MALT1:p-BCL10:TAK1:IKK	2
R-HSA-1169408	ISG15 antiviral mechanism	R-HSA-1176059	Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus	Nuclear Pore Complex (NPC)	3
R-HSA-1170546	Prolactin receptor signaling	R-HSA-1671691	PRLR-bound STAT5 is phosphorylated	PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5	3
R-HSA-1176059	reaction:Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus: is xrefed to this process	R-HSA-1176059	Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus	Nuclear Pore Complex (NPC)	3
R-HSA-1181150	Signaling by NODAL	R-HSA-1181156	Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL	NODAL:ACVR1B:ACVR2A,B:EGF-CFC	2
R-HSA-1181150	Signaling by NODAL	R-HSA-1181355	Phosphorylation of R-SMAD2/3 by NODAL receptor	NODAL:p-NODAL Receptor	2
R-HSA-1222516	reaction:Intraphagosomal pH is lowered to 5 by V-ATPase: is xrefed to this process	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	V-ATPase	2
R-HSA-1222556	ROS and RNS production in phagocytes	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	V-ATPase	2
R-HSA-1222556	ROS and RNS production in phagocytes	R-HSA-6789092	NOX2 generates superoxide anion from oxygen	NOX2 complex:RAC2:GTP	3
R-HSA-1236973	Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236967	Alkalization of the phagosomal lumen by NOX2	NOX2 complex	2
R-HSA-1250196	SHC1 events in ERBB2 signaling	R-HSA-1250195	SHC1 phosphorylation by ERBB2 heterodimers	SHC1:Phosphorylated ERBB2 heterodimers	3
R-HSA-1250196	SHC1 events in ERBB2 signaling	R-HSA-1250463	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers	GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers	3
R-HSA-1250196	SHC1 events in ERBB2 signaling	R-HSA-8934446	Activated PKC phosphorylates SHC1	Activated PRKCA,(PRKCD,PRKCE)	2
R-HSA-1250342	PI3K events in ERBB4 signaling	R-HSA-1250370	Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers	PI3K:p-ERBB4cyt1	3
R-HSA-1250347	SHC1 events in ERBB4 signaling	R-HSA-1250348	Phosphorylation of SHC1 by ERBB4 homodimers	SHC1:p-ERBB4	3
R-HSA-1250347	SHC1 events in ERBB4 signaling	R-HSA-1250383	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4	GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4	3
R-HSA-1251932	PLCG1 events in ERBB2 signaling	R-HSA-1251922	PLCG1 phosphorylation by p-EGFR:p-ERBB2	EGF:p-EGFR:p-ERBB2:PLCG1	3
R-HSA-1253288	Downregulation of ERBB4 signaling	R-HSA-1253282	ERBB4 ubiquitination by WWP1/ITCH	ERBB4/m80/s80:WWP1/ITCH	2
R-HSA-1257604	PI3K/AKT Signaling	R-HSA-2316434	PI3K phosphorylates PIP2 to PIP3	Activator:PI3K	3
R-HSA-1266695	Interleukin-7 signaling	R-HSA-1295540	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5 phosphorylates STAT5	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B	3
R-HSA-1266695	Interleukin-7 signaling	R-HSA-8983059	TSLP:IL7R:CRLF2 phosphorylates STAT3	IL7R:TSLP:CRLF2:STAT3	3
R-HSA-1266695	Interleukin-7 signaling	R-HSA-8983063	JAK3 is phosphorylated after IL7:IL7R binding	IL7:IL7R:JAK1:IL2RG:JAK3	3
R-HSA-1296041	Activation of G protein gated Potassium channels	R-HSA-1013012	Binding of Gbeta/gamma to GIRK/Kir3 channels	GABAB receptor:GABA	2
R-HSA-1296041	Activation of G protein gated Potassium channels	R-HSA-1013013	Association of GABA B receptor with G protein beta-gamma subunits	GABAB receptor:GABA	2
R-HSA-1296041	Activation of G protein gated Potassium channels	R-HSA-1013020	Activation of GIRK/Kir3 Channels	GABA B receptor G-protein beta-gamma and Kir3 channel complex	2
R-HSA-1296061	HCN channels	R-HSA-1296043	Activation of HCN channels	HCN channel bound to cAMP	2
R-HSA-1300642	Sperm Motility And Taxes	R-HSA-2534359	CatSper Channel Mediated Calcium Transport	Activated CatSper Channel	2
R-HSA-1307965	betaKlotho-mediated ligand binding	R-HSA-1307963	Autocatalytic phosphorylation of BetaKlotho-bound FGFR4	FGFR4:HS:KLB:FGF19	2
R-HSA-1358803	Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358790	RNF41 ubiquitinates ERBB3	ERBB3:RNF41	2
R-HSA-1358803	Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358792	RNF41 ubiquitinates activated ERBB3	NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41	3
R-HSA-139853	Elevation of cytosolic Ca2+ levels	R-HSA-139855	P2X1-mediated entry of Ca++ from plasma	P2X purinoreceptors:ATP	2
R-HSA-139853	Elevation of cytosolic Ca2+ levels	R-HSA-434798	Calcium influx via CRAC	CRAC channel	2
R-HSA-140875	Common Pathway of Fibrin Clot Formation	R-HSA-141026	factor Va -> factor Vi	Activated protein C:Protein S	2
R-HSA-140875	Common Pathway of Fibrin Clot Formation	R-HSA-5591040	Activated protein C cleaves Factor Va intermediate form for Factor Va	Activated protein C:Protein S	2
R-HSA-140875	Common Pathway of Fibrin Clot Formation	R-HSA-5607002	Activated protein C cleaves factor VIIIa	Activated protein C:Protein S	2
R-HSA-1433557	Signaling by SCF-KIT	R-HSA-1433454	Phosphorylation of GAB2 by SFKs	GAB2:GRB2:p-SHP2:p-KIT complex	3
R-HSA-1433557	Signaling by SCF-KIT	R-HSA-1433488	Phosphorylation of SHP2 by SFKs	SHP2:SFKs:p-KIT:sSCF dimer:p-KIT	3
R-HSA-1433557	Signaling by SCF-KIT	R-HSA-1433514	Synthesis of PIP3 from PIP2 by PI3K	PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex	3
R-HSA-1433557	Signaling by SCF-KIT	R-HSA-1433542	Phosphorylation and activation of VAV1	SFKs:p-KIT complex	3
R-HSA-1433557	Signaling by SCF-KIT	R-HSA-1470009	Phosphorylation of STATs	p-JAK2:SFKs:p-KIT complex:STATs	3
R-HSA-1433557	Signaling by SCF-KIT	R-HSA-205289	Autophosphorylation of KIT	KIT:sSCF dimer:KIT	2
R-HSA-1433559	Regulation of KIT signaling	R-HSA-1433506	Phosphorylation of APS	APS dimer:p-c-Kit:SFKs complex	3
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445143	RAB8A,10,13,14 hydrolyze GTP	GGC-RAB8A,10,13,14:GTP	2
R-HSA-1483248	Synthesis of PIPs at the ER membrane	R-HSA-6809777	PI3P is dephosphorylated to PI by MTMR2:SBF1	MTMR2:SBF1	2
R-HSA-1483248	Synthesis of PIPs at the ER membrane	R-HSA-6809778	PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1	MTMR2:SBF1	2
R-HSA-1489509	DAG and IP3 signaling	R-HSA-169683	IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol	ITPR:I(1,4,5)P3 tetramer	2
R-HSA-1502540	Signaling by Activin	R-HSA-1181149	ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin	Activin A,AB,B:ACVR2A,B:ACVR1B	2
R-HSA-1502540	Signaling by Activin	R-HSA-1549526	Phosphorylation of SMAD2/3 by Activin:Activin Receptor	Activin:ACVR2A,B:p-ACVR1B,C	2
R-HSA-1502540	Signaling by Activin	R-HSA-2470508	ACVR2A/B (ActRIIA/B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin	Activin AB,B:ACVR2A,B:ACVR1C	2
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-75097	Transport of the export-competent mRNP complex through the NPC	Nuclear Pore Complex (NPC)	3
R-HSA-163210	Formation of ATP by chemiosmotic coupling	R-HSA-164832	ATPase synthesizes ATP	ATPase:ADP:Pi	3
R-HSA-163210	Formation of ATP by chemiosmotic coupling	R-HSA-164834	Enzyme-bound ATP is released	ATPase:ATP	3
R-HSA-163217	reaction:NADH enters the respiratory chain at Complex I: is xrefed to this process	R-HSA-163217	NADH enters the respiratory chain at Complex I	Complex I	2
R-HSA-1632852	Macroautophagy	R-HSA-1632857	ULK1 phosphorylates AMBRA1:Beclin-1 complex	p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101	2
R-HSA-1632852	Macroautophagy	R-HSA-5672017	Rheb in the mTORC1 complex hydrolyses GTP	mTORC1:Ragulator:Rag:GNP:RHEB:GTP	2
R-HSA-1632852	Macroautophagy	R-HSA-5679205	ULK1 phosphorylates Beclin-1	p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101	2
R-HSA-164378	PKA activation in glucagon signalling	R-HSA-164377	Activated Adenylate cyclase catalyses cAMP synthesis	Gs-activated adenylate cyclase	2
R-HSA-164832	reaction:ATPase synthesizes ATP: is xrefed to this process	R-HSA-164832	ATPase synthesizes ATP	ATPase:ADP:Pi	3
R-HSA-164834	reaction:Enzyme-bound ATP is released: is xrefed to this process	R-HSA-164834	Enzyme-bound ATP is released	ATPase:ATP	3
R-HSA-167021	PLC-gamma1 signalling	R-HSA-167683	TrkA phosphorylates PLCG1	Active TrkA receptor:PLCG1 complex	2
R-HSA-167044	Signalling to RAS	R-HSA-167019	SHC, complexed with TrkA, is tyrosine-phosphorylated	Activated TrkA receptor:SHC	3
R-HSA-170660	Adenylate cyclase activating pathway	R-HSA-170676	Adenylate cyclase converts ATP into cyclic AMP	G alpha-olf:GTP:Adenylate cyclase (active) complex	2
R-HSA-170660	Adenylate cyclase activating pathway	R-HSA-170685	Adenylaye cyclase increases the GTPase activity of G alpha-olf	G alpha-olf:GTP:Adenylate cyclase (active) complex	2
R-HSA-170670	Adenylate cyclase inhibitory pathway	R-HSA-170666	Adenylate cyclase increases the GTPase activity of G alpha-olf	(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)	2
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170796	NPC transports GCK1:GKRP from cytosol to nucleoplasm	Nuclear Pore Complex (NPC)	3
R-HSA-170968	Frs2-mediated activation	R-HSA-170977	FRS2 is phosphorylated by active TrkA receptor	Active TrkA receptor:FRS2 complex	2
R-HSA-170968	Frs2-mediated activation	R-HSA-170979	(Frs2)C3G stimulates nucleotide exchange on Rap1	Active TrkA receptor:p-FRS2:CRKL:RAPGEF1	2
R-HSA-170984	ARMS-mediated activation	R-HSA-169904	C3G stimulates nucleotide exchange on Rap1	Active TrkA receptor:Phospho-ARMS:Crk:C3G complex	3
R-HSA-170984	ARMS-mediated activation	R-HSA-169905	ARMS is phosphorylated by active TrkA receptor	Active TrkA receptor:ARMS:Crk complex	3
R-HSA-173623	Classical antibody-mediated complement activation	R-HSA-173631	Activation of C1s	Antigen:IgG:C1 with activated C1R	2
R-HSA-173736	Alternative complement activation	R-HSA-174551	Formation of alternative pathway C5 convertase	Cell surface:C3b:Bb:Properdin	2
R-HSA-174577	Activation of C3 and C5	R-HSA-166817	Cleavage of C3 by C3 convertases	C3 convertases	2
R-HSA-174577	Activation of C3 and C5	R-HSA-173680	Activation of C5	C5 convertases	2
R-HSA-180292	GAB1 signalosome	R-HSA-177930	GAB1 phosphorylation by EGFR kinase	GAB1:GRB2-EGF-Phospho-EGFR dimer	3
R-HSA-180336	SHC1 events in EGFR signaling	R-HSA-177933	SHC1 phosphorylation by phosphorylated EGFR	EGF-like ligands:p-6Y EGFR:SHC1	3
R-HSA-181429	Serotonin Neurotransmitter Release Cycle	R-HSA-380901	Release of docked serotonin loaded synaptic vesicle	Docked serotonin loaded synaptic vesicle	4
R-HSA-181429	Serotonin Neurotransmitter Release Cycle	R-HSA-380905	Serotonin loaded synaptic vesicle docking and priming	Serotonin loaded synaptic vesicle	2
R-HSA-181430	Norepinephrine Neurotransmitter Release Cycle	R-HSA-374899	Release of noradrenaline at the synapse	Docked Noradrenalin loaded synaptic vesicle	4
R-HSA-181430	Norepinephrine Neurotransmitter Release Cycle	R-HSA-374922	Noradrenalin synaptic vesicle docking and priming	Noradrenalin loaded synaptic vesicle	2
R-HSA-182971	EGFR downregulation	R-HSA-182969	Phosphorylation of CBL (EGFR:CBL)	EGF-like ligands:p-6Y-EGFR:CBL	3
R-HSA-182971	EGFR downregulation	R-HSA-182986	CBL-mediated ubiquitination of CIN85	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15	3
R-HSA-182971	EGFR downregulation	R-HSA-182993	Ubiquitination of stimulated EGFR (CBL)	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL	3
R-HSA-182971	EGFR downregulation	R-HSA-183051	CBL ubiquitinates Sprouty	EGF:Phospho-EGFR dimer:CBL:Phospho-Sprouty	3
R-HSA-182971	EGFR downregulation	R-HSA-183058	Phosphorylation of CBL (EGFR:GRB2:CBL)	EGF-like ligands:p-6Y-EGFR:CBL:GRB2	3
R-HSA-182971	EGFR downregulation	R-HSA-183084	CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix	EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP	3
R-HSA-182971	EGFR downregulation	R-HSA-183089	CBL binds and ubiquitinates phosphorylated Sprouty	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL	3
R-HSA-182971	EGFR downregulation	R-HSA-8867041	EGFR phosphorylates EPS15	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM	3
R-HSA-186763	Downstream signal transduction	R-HSA-1524186	Phosphorylation of PLCgamma by PDGFR	PDGF:Phospho-PDGF receptor dimer:PLC-gamma	2
R-HSA-186797	Signaling by PDGF	R-HSA-186786	Autophosphorylation of PDGF beta receptors	PDGF beta receptor:PDGF chain B homodimer	2
R-HSA-186797	Signaling by PDGF	R-HSA-389083	Autophosphorylation of PDGF alpha receptors	PDGF alpha receptor: PDGF dimers	2
R-HSA-186797	Signaling by PDGF	R-HSA-389086	Autophosphorylation of PDGF alpha/beta receptors	PDGF alpha/beta:PDGF AB and BB dimers	2
R-HSA-187024	NGF-independant TRKA activation	R-HSA-9613023	NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates	Ade-Rib:ADORA2A:NTRK1,2	2
R-HSA-190322	FGFR4 ligand binding and activation	R-HSA-190326	Autocatalytic phosphorylation of FGFR4	FGFR4 homodimer bound to FGF	2
R-HSA-190370	FGFR1b ligand binding and activation	R-HSA-190427	Autocatalytic phosphorylation of FGFR1b	FGFR1b homodimer bound to FGF	2
R-HSA-190371	FGFR3b ligand binding and activation	R-HSA-190385	Autocatalytic phosphorylation of FGFR3b	FGFR3b homodimer bound to FGF	2
R-HSA-190372	FGFR3c ligand binding and activation	R-HSA-190388	Autocatalytic phosphorylation of FGFR3c	FGFR3c homodimer bound to FGF	2
R-HSA-190373	FGFR1c ligand binding and activation	R-HSA-190429	Autocatalytic phosphorylation of FGFR1c	FGFR1c homodimer bound to FGF	2
R-HSA-190374	FGFR1c and Klotho ligand binding and activation	R-HSA-191062	Autocatalytic phosphorylation of Klotho-bound FGFR1c	FGF23 bound to Klotho and FGFR1c	2
R-HSA-190375	FGFR2c ligand binding and activation	R-HSA-190413	Autocatalytic phosphorylation of FGFR2c	FGFR2c homodimer bound to FGF	2
R-HSA-190377	FGFR2b ligand binding and activation	R-HSA-190408	Autocatalytic phosphorylation of FGFR2b	FGFR2b homodimer bound to FGF	2
R-HSA-193681	Ceramide signalling	R-HSA-193672	Sphingomyelinase is activated by the NGF:p75NTR complex	mature NGF homodimer:p75NTR	2
R-HSA-1963640	GRB2 events in ERBB2 signaling	R-HSA-1250498	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.	GRB2:SOS1:P-ERBB2:P-EGFR	3
R-HSA-1963640	GRB2 events in ERBB2 signaling	R-HSA-1306972	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers	GRB2:SOS1:P-ERBB2:P-ERBB4	3
R-HSA-1963642	PI3K events in ERBB2 signaling	R-HSA-1250462	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3	NRG1/2:p-ERBB3:p-ERBB2:PI3K	3
R-HSA-1963642	PI3K events in ERBB2 signaling	R-HSA-1306957	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR	PI3K:GRB2:GAB1:P-ERBB2:P-EGFR	3
R-HSA-1963642	PI3K events in ERBB2 signaling	R-HSA-1306979	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1	NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K	3
R-HSA-196780	Biotin transport and metabolism	R-HSA-199219	SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol	SLC5A6:PDZD11	2
R-HSA-198203	PI3K/AKT activation	R-HSA-198266	PI3K produces PIP3 and other phosphatidyl inositides	Phospho-IRS1/2:PI3K(p85:p110)	2
R-HSA-198203	PI3K/AKT activation	R-HSA-198295	TRKA phosphorylates IRS	Activated TrkA receptor:IRS1/2	3
R-HSA-199220	Vitamin B5 (pantothenate) metabolism	R-HSA-199206	SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol	SLC5A6:PDZD11	2
R-HSA-199992	trans-Golgi Network Vesicle Budding	R-HSA-376357	Vamp7 associated Lysosome to Plasma membrane transport	Vamp7:SNAP23:Syn4 Plasma membrane vesicle docking and fusion complex	2
R-HSA-199992	trans-Golgi Network Vesicle Budding	R-HSA-376364	Vamp8 associated secretory vesicle to plasma membrane transport	Vamp8:SNAP23:Syn4 Secretory granule docking and fusion complex	2
R-HSA-199992	trans-Golgi Network Vesicle Budding	R-HSA-376369	Vamp2 associated secretory vesicle to plasma membrane transport	Vamp2:SNAP23:Syn4 Secretory granule docking and fusion complex	2
R-HSA-201451	Signaling by BMP	R-HSA-201476	Activated type I receptor phosphorylates R-Smad1/5/8 directly	BMP:p-BMPR:Endofin:SMAD1/5/8	4
R-HSA-202040	G-protein activation	R-HSA-167408	The high affinity receptor complex binds to G-protein	Opioid:MOR	2
R-HSA-202424	Downstream TCR signaling	R-HSA-202307	Change of PKC theta conformation	Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394	2
R-HSA-202427	Phosphorylation of CD3 and TCR zeta chains	R-HSA-202233	Inactivation of Lck by Csk	Csk:p-PAG	2
R-HSA-202430	Translocation of ZAP-70 to Immunological synapse	R-HSA-202168	Phosphorylation of ZAP-70 by Lck	Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394	2
R-HSA-202433	Generation of second messenger molecules	R-HSA-202245	Phosphorylation of TBSMs in LAT	Activated ZAP-70	2
R-HSA-2029481	FCGR activation	R-HSA-2029449	Phosphorylation of SYK by Src kinases	clustered IgG-Ag:p-FCGRs:SYK	3
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029451	Activation of RAC1 by VAV	clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV	3
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029467	Activation of RAC1 by CRKII:DOCK180:ELMO	CRKII:DOCK180:ELMO complex recruited to phagocytic cup	3
R-HSA-2029485	Role of phospholipids in phagocytosis	R-HSA-169683	IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol	ITPR:I(1,4,5)P3 tetramer	2
R-HSA-2029485	Role of phospholipids in phagocytosis	R-HSA-2029271	PI3K phosphorylates PIP2 to PIP3	PI3K:p-6Y-SYK	3
R-HSA-203615	eNOS activation	R-HSA-1497810	Uncoupled eNOS favours the formation of superoxide	p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2	2
R-HSA-203615	eNOS activation	R-HSA-202127	NO biosynthesis	p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4	2
R-HSA-204005	COPII-mediated vesicle transport	R-HSA-203973	Vesicle budding	COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES	3
R-HSA-204005	COPII-mediated vesicle transport	R-HSA-5694409	Nucleotide exchange on RAB1	COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP	3
R-HSA-204005	COPII-mediated vesicle transport	R-HSA-5694425	NSF ATPase activity dissociates cis-SNARE	cis-SNARE:NSF hexamer:3xSNAP	2
R-HSA-204005	COPII-mediated vesicle transport	R-HSA-5694527	Loss of SAR1B GTPase	COPII cargo receptors:SAR1B:GTP:SEC23:SEC24	3
R-HSA-204005	COPII-mediated vesicle transport	R-HSA-6814833	TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP	RAB1:GTP:TBC1D20	2
R-HSA-205043	NRIF signals cell death from the nucleus	R-HSA-204949	NRIF and TRAF6 may activate JNK	NGF ligand:p75NTR:NRIF:TRAF6	3
R-HSA-209560	NF-kB is activated and signals survival	R-HSA-193703	IKKbeta is activated	NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta	3
R-HSA-209560	NF-kB is activated and signals survival	R-HSA-193705	IKKbeta phosphorylates IkB causing NF-kB to dissociate	NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta	3
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-1912386	Ubiquitination of NOTCH1 by ITCH in the absence of ligand	NOTCH1:NUMB:ITCH	3
R-HSA-212676	Dopamine Neurotransmitter Release Cycle	R-HSA-380574	Dopamine synaptic vesicle docking and priming	Dopamine loaded synaptic vesicle	2
R-HSA-2142691	Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-266012	Further cleavage of LTD4 forms LTE4	DPEP1,2,3 dimers	2
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	R-HSA-2169050	SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7	TGFB1:TGFBR2:p-TGFBR1:SMAD7:SMURF/NEDD4L	3
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	R-HSA-170843	TGFBR2 phosphorylates TGFBR1	TGFB1:TGFBR2:TGFBR1	2
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	R-HSA-170846	TGFBR2 recruits TGFBR1	Dimeric TGFB1:TGFBR2 homodimer	2
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	R-HSA-170868	Activated type I receptor phosphorylates SMAD2/3 directly	TGFB1:p-TGFBR:SARA:SMAD2/3	4
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	R-HSA-4332236	CBL neddylates TGFBR2	TGFBR2:CBL	2
R-HSA-2179392	EGFR Transactivation by Gastrin	R-HSA-2179407	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)	GRB2:SOS1:HB-EGF:p-6Y-EGFR	3
R-HSA-2316434	reaction:PI3K phosphorylates PIP2 to PIP3: is xrefed to this process	R-HSA-2316434	PI3K phosphorylates PIP2 to PIP3	Activator:PI3K	3
R-HSA-2424491	DAP12 signaling	R-HSA-2395801	Phosphorylation of LAT by p-SYK	DAP12 Receptors:p-DAP12:p-6Y-SYK	2
R-HSA-2424491	DAP12 signaling	R-HSA-2396594	Phosphorylation of SLP-76 by p-SYK	DAP12 Receptors:p-DAP12:p-6Y-SYK	2
R-HSA-2424491	DAP12 signaling	R-HSA-2424476	Activation of RAC1 by VAV2/3	p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV	2
R-HSA-2424491	DAP12 signaling	R-HSA-2424480	PI3K phosphorylates PIP2 to PIP3	DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K	2
R-HSA-2424491	DAP12 signaling	R-HSA-2424484	Phosphorylation of BTK by p-SYK	DAP12 Receptors:p-DAP12:p-6Y-SYK	2
R-HSA-2424491	DAP12 signaling	R-HSA-2424486	Phosphorylation and activation of VAV2/VAV3 by SYK	DAP12 Receptors:p-DAP12:p-6Y-SYK	2
R-HSA-2424491	DAP12 signaling	R-HSA-2424487	Phosphorylation of PLC-gamma by p-BTK/p-SYK	p-SYK/p-BTK	2
R-HSA-2428928	IRS-related events triggered by IGF1R	R-HSA-2428926	IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4	IGF1,2:p-IGF1R:IRS1,2,4	2
R-HSA-2428933	SHC-related events triggered by IGF1R	R-HSA-2404193	IGF1R phosphorylates SHC1	IGF1,2:p-3Y-IGF1R:SHC1	2
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	R-HSA-2454239	Phosphorylation of SYK	Clustered p:LYN:p-FCERI:IgE:allergin:SYK	3
R-HSA-2485179	Activation of the phototransduction cascade	R-HSA-2514867	cGMP:CNG transports Na+ and Ca2+ into the rod outer segment	cGMP:CNG channel	2
R-HSA-2485179	Activation of the phototransduction cascade	R-HSA-74059	PDE6 hydrolyses cGMP to GMP	GNAT1-GTP:PDE6	2
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	R-HSA-1638821	PP2A-B56 dephosphorylates centromeric cohesin	p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules	3
R-HSA-2514859	Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2584246	GNAT1-GTP hydrolyses its bound GTP to GDP	GNAT1-GTP:PDE6	2
R-HSA-2534359	reaction:CatSper Channel Mediated Calcium Transport: is xrefed to this process	R-HSA-2534359	CatSper Channel Mediated Calcium Transport	Activated CatSper Channel	2
R-HSA-264876	Insulin processing	R-HSA-9023173	Insulin secretory granule docks at the plasma membrane	Core SNARE Complex	2
R-HSA-2672351	Stimuli-sensing channels	R-HSA-2671885	ASICs transport extracellular Na+ to cytosol	ASIC trimers:H+	2
R-HSA-2672351	Stimuli-sensing channels	R-HSA-2855020	RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol	RYR tetramer:FKBP1B tetramer:CASQ polymer:TRDN:junctin	3
R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730870	Phosphorylation of PIP2 to PIP3 by PI3K	p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K	2
R-HSA-2871796	FCERI mediated MAPK activation	R-HSA-2730840	Activation of RAC1 by VAV	p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV	2
R-HSA-2871796	FCERI mediated MAPK activation	R-HSA-2730856	Autophosphorylation of PAK	p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer	2
R-HSA-2871809	FCERI mediated Ca+2 mobilization	R-HSA-169683	IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol	ITPR:I(1,4,5)P3 tetramer	2
R-HSA-2871809	FCERI mediated Ca+2 mobilization	R-HSA-2730847	Hydrolysis of PIP2 by PLCG	p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3	2
R-HSA-2871809	FCERI mediated Ca+2 mobilization	R-HSA-2730888	Phosphorylation of PLC-gamma	p-SYK/p-BTK	3
R-HSA-2871837	FCERI mediated NF-kB activation	R-HSA-2730876	Phosphorylation of IKK-beta by TAK1	DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:activated TAK1 complex	2
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	R-HSA-3000348	Conjugation of SUMO2 to SP100	Nuclear Pore Complex (NPC)	3
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	R-HSA-3000399	Conjugation of SUMO1 to SP100	Nuclear Pore Complex (NPC)	3
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	R-HSA-3000411	Conjugation of SUMO2 to PML	Nuclear Pore Complex (NPC)	3
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	R-HSA-5228508	RANBP2 SUMOylates PML with SUMO1	Nuclear Pore Complex (NPC)	3
R-HSA-3214847	HATs acetylate histones	R-HSA-3301237	KAT2 complexes acetylate histone H3	KAT2A,B complexes	2
R-HSA-3214847	HATs acetylate histones	R-HSA-3301345	Elongator complex acetylates replicative histone H3, H4	Elongator complex	2
R-HSA-3232142	SUMOylation of ubiquitinylation proteins	R-HSA-5228523	Conjugation of SUMO1 to MDM2	Nuclear Pore Complex (NPC)	3
R-HSA-3299685	Detoxification of Reactive Oxygen Species	R-HSA-1222376	NOX2 generates superoxide from oxygen	NOX2 complex	2
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	R-HSA-5252041	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm	Nuclear Pore Complex (NPC)	3
R-HSA-354192	Integrin alphaIIb beta3 signaling	R-HSA-354124	Phosphorylation of pPTK2 by SRC	Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2	3
R-HSA-354192	Integrin alphaIIb beta3 signaling	R-HSA-354173	Activation of Rap1 by cytosolic GEFs	CalDAG-GEFs:DAG:Ca2+	2
R-HSA-354192	Integrin alphaIIb beta3 signaling	R-HSA-429441	SYK activation by SRC	Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK	3
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	R-HSA-372693	Phosphorylation of BCAR1 by SRC-PTK2 complex	PTK2 bound p130Cas complex	3
R-HSA-373753	Nephrin family interactions	R-HSA-373747	Phosphorylation of nephrin by FYN	NPHS1 dimer:KIRREL:FYN	2
R-HSA-376172	DSCAM interactions	R-HSA-451347	Activation of JNK by DSCAM	DSCAM:p-S144-PAK1:RAC1:GTP	2
R-HSA-376172	DSCAM interactions	R-HSA-451366	Activation of p38MAPK by DSCAM	DSCAM:p-S144-PAK1:RAC1:GTP	2
R-HSA-382556	ABC-family proteins mediated transport	R-HSA-8866546	RNF5 and RNF185 ubiquitinate misfolded CFTR	misfolded CFTR:ERAD complex	3
R-HSA-389948	PD-1 signaling	R-HSA-389758	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases	PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1	2
R-HSA-392451	G beta:gamma signalling through PI3Kgamma	R-HSA-392300	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3	G-protein beta-gamma:PI3K gamma	2
R-HSA-392517	Rap1 signalling	R-HSA-354173	Activation of Rap1 by cytosolic GEFs	CalDAG-GEFs:DAG:Ca2+	2
R-HSA-3928662	EPHB-mediated forward signaling	R-HSA-3928577	ROCK phosphorylates LIMK1,2	RHOA:GTP:ROCK1,ROCK2	2
R-HSA-3928662	EPHB-mediated forward signaling	R-HSA-3928583	FYN phosphorylates NMDAR2B	EFNBs:p-EPHBs:SFKs:Glu:NMDAR:Gly	3
R-HSA-3928662	EPHB-mediated forward signaling	R-HSA-3928627	EPHB phosphorylates TIAM1	EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1	3
R-HSA-3928662	EPHB-mediated forward signaling	R-HSA-3928632	ITSN1 exchanges GTP for GDP on CDC42, activating it	p-EPHBs:EFNBs:ITSN1:N-WASP	2
R-HSA-3928663	EPHA-mediated growth cone collapse	R-HSA-3928616	Activated ROCK phosphorylates MRLCs	RHOA:GTP:ROCK1,ROCK2	2
R-HSA-3928663	EPHA-mediated growth cone collapse	R-HSA-3928648	SFKs phosphorylate NGEF	EFNAs:p-EPHAs:SFKs:NGEF	2
R-HSA-3928664	Ephrin signaling	R-HSA-3928580	SFKs phosphorylate EFNBs	EPHBs:EFNBs:SRC,FYN	2
R-HSA-3928664	Ephrin signaling	R-HSA-3928594	SFKs phosphorylate GIT1	EPHBs:EFNBs:SRC,FYN	2
R-HSA-3928664	Ephrin signaling	R-HSA-3928625	PAKs autophosphorylate	EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3	2
R-HSA-3928664	Ephrin signaling	R-HSA-3928640	PAKs phosphorylate MLC	EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3	2
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	R-HSA-3928604	SFKs phosphorylate VAV2,3	EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3	2
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	R-HSA-3928628	VAV exchanges GTP for GDP on RAC1, activating it	EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3	2
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	R-HSA-3928642	TIAM1 exchanges GTP for GDP on RAC1, activating it	EFNAs:p-EPHAs:SFKs:TIAM1	2
R-HSA-399710	Activation of AMPA receptors	R-HSA-399711	Activation of Ca impermeable AMPA receptors	Ca impermeable AMPA receptor ligand complex	2
R-HSA-399710	Activation of AMPA receptors	R-HSA-399712	Activation of Ca permeable AMPA receptors	Ca permeable AMPA receptor ligand complex	2
R-HSA-399710	Activation of AMPA receptors	R-HSA-420980	Activation of Ca permeable AMPA receptors	Ca permeable AMPA receptor ligand complex	2
R-HSA-399954	Sema3A PAK dependent Axon repulsion	R-HSA-399939	Autophosphorylation of PAK	Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK	3
R-HSA-399954	Sema3A PAK dependent Axon repulsion	R-HSA-399952	Phosphorylation of LIMK-1 by PAK	Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK	3
R-HSA-399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399935	Inactivation of R-Ras by Sema3A-Plexin-A GAP activity	Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1	3
R-HSA-399997	Acetylcholine regulates insulin secretion	R-HSA-399998	Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate	PLC beta1,2,3:G-alpha(q):GTP	2
R-HSA-4085377	SUMOylation of SUMOylation proteins	R-HSA-4551649	RANBP2 SUMOylates RANBP2 with SUMO1	Nuclear Pore Complex (NPC)	3
R-HSA-4085377	SUMOylation of SUMOylation proteins	R-HSA-4551679	RANBP2 SUMOylates RANBP2 with SUMO2	Nuclear Pore Complex (NPC)	3
R-HSA-4086398	Ca2+ pathway	R-HSA-3965444	WNT:FZD complex promotes G-protein nucleotide exchange	WNT5A/11:FZD:G-protein (alpha o/t2) inactive	3
R-HSA-4086398	Ca2+ pathway	R-HSA-398193	PLC beta-mediated PIP2 hydrolysis	G-protein beta-gamma:PLC beta 1/2/3	2
R-HSA-4086398	Ca2+ pathway	R-HSA-4086392	PDE6 hydrolyses cGMP to GMP	GNAT2:PDE6	2
R-HSA-4086398	Ca2+ pathway	R-HSA-4420052	Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT	ITPR:I(1,4,5)P3 tetramer	2
R-HSA-416476	G alpha (q) signalling events	R-HSA-114688	PLC-beta hydrolyses PIP2 to DAG and IP3	PLC beta:G alpha (q/11)	2
R-HSA-416476	G alpha (q) signalling events	R-HSA-379048	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive)	4
R-HSA-416476	G alpha (q) signalling events	R-HSA-418582	G alpha (q) auto-inactivates by hydrolysing GTP to GDP	G-protein alpha (q/11): GTP	2
R-HSA-416482	G alpha (12/13) signalling events	R-HSA-114544	p115-RhoGEF activation of RHOA	G13-activated p115-RhoGEF	2
R-HSA-416482	G alpha (12/13) signalling events	R-HSA-418574	G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP	G-protein alpha (12/13):GTP	2
R-HSA-416482	G alpha (12/13) signalling events	R-HSA-751029	Liganded G12/13-activating GPCR acts as a GEF for G12/13	Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive).	3
R-HSA-416550	Sema4D mediated inhibition of cell attachment and migration	R-HSA-416546	Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity	Sema4D:pPlexin-B1:Met:Rnd1	2
R-HSA-416572	Sema4D induced cell migration and growth-cone collapse	R-HSA-419087	LIM kinase phosphorylation by ROCK	Activated ROCK:RhoA/B/C:GTP	2
R-HSA-416572	Sema4D induced cell migration and growth-cone collapse	R-HSA-419197	Myosin regulatory light chain phosphorylation by ROCK	Activated ROCK:RhoA/B/C:GTP	2
R-HSA-416993	Trafficking of GluR2-containing AMPA receptors	R-HSA-416639	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites	Activated conventional protein kinase C	2
R-HSA-416993	Trafficking of GluR2-containing AMPA receptors	R-HSA-421007	Endocytosis of Ca impermeable AMPA receptors	Activated conventional protein kinase C	2
R-HSA-418217	G beta:gamma signalling through PLC beta	R-HSA-398193	PLC beta-mediated PIP2 hydrolysis	G-protein beta-gamma:PLC beta 1/2/3	2
R-HSA-418555	G alpha (s) signalling events	R-HSA-164381	G alpha (s) auto-inactivates by hydrolysing GTP to GDP	Gs:GTP	2
R-HSA-418555	G alpha (s) signalling events	R-HSA-379044	Liganded Gs-activating GPCR acts as a GEF for Gs	Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive)	3
R-HSA-418555	G alpha (s) signalling events	R-HSA-392129	Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate	Gs-activated adenylate cyclase	2
R-HSA-418555	G alpha (s) signalling events	R-HSA-8851797	ADRB2 in ADRB2:GRK complex is phosphorylated	ADRB2:Catecholamine:GRK	2
R-HSA-418555	G alpha (s) signalling events	R-HSA-8964252	G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC	G alpha (s):GTP:SRC	2
R-HSA-418592	ADP signalling through P2Y purinoceptor 1	R-HSA-428941	P2Y purinoceptor 1 activates MAP kinase p38 alpha	G-protein alpha (q/11): GTP	2
R-HSA-418594	G alpha (i) signalling events	R-HSA-380073	Liganded Gi-activating GPCR acts as a GEF for Gi	Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive)	3
R-HSA-418594	G alpha (i) signalling events	R-HSA-392129	Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate	Gs-activated adenylate cyclase	2
R-HSA-418594	G alpha (i) signalling events	R-HSA-392212	G alpha (i) auto-inactivates by hydrolysing GTP to GDP	G alpha (i): GTP	2
R-HSA-418594	G alpha (i) signalling events	R-HSA-420883	Opsins act as GEFs for G alpha-t	Opsins:photon	2
R-HSA-418594	G alpha (i) signalling events	R-HSA-8964242	G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC	G alpha (i):GTP:SRC-1	2
R-HSA-418594	G alpha (i) signalling events	R-HSA-8982020	G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated	G alpha (i):GTP:RGS	2
R-HSA-418594	G alpha (i) signalling events	R-HSA-8982637	Opsins binds G alpha-t	Opsins:photon	2
R-HSA-418594	G alpha (i) signalling events	R-HSA-8982640	G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)	Opsins:photon	2
R-HSA-418597	G alpha (z) signalling events	R-HSA-392129	Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate	Gs-activated adenylate cyclase	2
R-HSA-418597	G alpha (z) signalling events	R-HSA-749453	Liganded Gz-activating GPCR acts as a GEF for Gz	Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive)	3
R-HSA-418597	G alpha (z) signalling events	R-HSA-751040	PKC phosphorylates G alpha (z)	G-alpha(z):GTP:PKC	2
R-HSA-418597	G alpha (z) signalling events	R-HSA-8982021	G alpha (z) in G alpha (z):RGS complex is inactivated	G alpha (z):GTP:RGS16,17,20	2
R-HSA-418885	DCC mediated attractive signaling	R-HSA-374701	Phosphorylation of DCC by Fyn	Netrin1:DCC oligomer:pPTK2:Fyn/src	3
R-HSA-418885	DCC mediated attractive signaling	R-HSA-418850	Activation of Cdc42	Netrin:DCC oligomer:pFAK:Fyn:Nck-1:Rho GEFs DOCK/Trio	3
R-HSA-418885	DCC mediated attractive signaling	R-HSA-418856	Activation of Rac1	Netrin:DCC oligomer:pFAK:Fyn:Nck-1:Rho GEFs DOCK/Trio	3
R-HSA-418889	Ligand-independent caspase activation via DCC	R-HSA-418845	Activation of caspase-3	DCC:DIP13alpha:Caspase-9	3
R-HSA-422356	Regulation of insulin secretion	R-HSA-169683	IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol	ITPR:I(1,4,5)P3 tetramer	2
R-HSA-422356	Regulation of insulin secretion	R-HSA-265166	Exocytosis of Insulin	Core SNARE Complex	2
R-HSA-422356	Regulation of insulin secretion	R-HSA-265645	Calcium Influx through Voltage-gated Calcium Channels	Voltage-gated Calcium Channels (pancreatic beta cell)	2
R-HSA-425397	Transport of vitamins, nucleosides, and related molecules	R-HSA-429581	Na+-dependent multivitamin transporter	SLC5A6:PDZD11	2
R-HSA-425410	Metal ion SLC transporters	R-HSA-904830	Ferroportin mediates iron efflux on macrophages	SLC40A1:CP:6Cu2+	2
R-HSA-428540	Activation of RAC1	R-HSA-428535	Activation of RAC1 by SOS	SLIT2:ROBO1:NCK:SOS	2
R-HSA-428543	Inactivation of CDC42 and RAC1	R-HSA-428533	Inactivation of CDC42	SLIT2:ROBO1:SRGAP	2
R-HSA-428890	Role of ABL in ROBO-SLIT signaling	R-HSA-428888	Phosphorylation of ROBO1 by ABL kinase	SLIT2:ROBO1:ABL	2
R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-164377	Activated Adenylate cyclase catalyses cAMP synthesis	Gs-activated adenylate cyclase	2
R-HSA-432142	Platelet sensitization by LDL	R-HSA-432129	FGR binds and phosphorylates LRP8	LDL:LRP8:FGR	3
R-HSA-434316	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-399998	Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate	PLC beta1,2,3:G-alpha(q):GTP	2
R-HSA-438066	Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-432164	Ca2+ influx into the post-synaptic cell	Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors	3
R-HSA-438066	Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438037	Membrane depolarization upon activation of Ca impermeable AMPA receptors	Ca impermeable AMPA receptor ligand complex	2
R-HSA-4419969	Depolymerisation of the Nuclear Lamina	R-HSA-5229194	Depolymerization of lamin filaments after PKC-mediated phosphorylation	DAG:active PKC:Ca+2	2
R-HSA-4420097	VEGFA-VEGFR2 Pathway	R-HSA-4420206	Phosphorylation of SRC-1	VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1	3
R-HSA-4420097	VEGFA-VEGFR2 Pathway	R-HSA-5218804	p38 MAPK activation by VEGFR	VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP	3
R-HSA-4420097	VEGFA-VEGFR2 Pathway	R-HSA-5218809	PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118	VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN	3
R-HSA-4420097	VEGFA-VEGFR2 Pathway	R-HSA-5218819	VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3	VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K	3
R-HSA-4420097	VEGFA-VEGFR2 Pathway	R-HSA-5218828	PTK2/SRC-1 phosphorylates BCAR1	VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1:BCAR1	3
R-HSA-4420097	VEGFA-VEGFR2 Pathway	R-HSA-5218839	DOCK180:ELMO exchanges GTP for GDP, activating RAC1	CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN	3
R-HSA-4420097	VEGFA-VEGFR2 Pathway	R-HSA-5218841	NADPH oxidase 2 generates superoxide from oxygen	NOX2 complex:RAC1:GTP	2
R-HSA-4420097	VEGFA-VEGFR2 Pathway	R-HSA-5218850	VAV exchanges GTP for GDP on RAC1, activating it	p-VAV family:PIP3:RAC1:GDP	2
R-HSA-4420097	VEGFA-VEGFR2 Pathway	R-HSA-5218851	p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407	VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:p-Y402-PTK2B	3
R-HSA-442720	CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442715	Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP	ADCY1,ADCY8:CALM1:4xCa2+	2
R-HSA-442982	Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442732	NMDA-activated RASGRF1 activates RAS	Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+	3
R-HSA-446203	Asparagine N-linked glycosylation	R-HSA-446209	Transfer of N-glycan to the protein	OST complex	2
R-HSA-451307	Activation of Na-permeable kainate receptors	R-HSA-451310	Activation of Edited Kainate receptors	Edited Kainate Receptor-glutamate complex	2
R-HSA-451308	Activation of Ca-permeable Kainate Receptor	R-HSA-451311	Activation of Ca-permeable Kainate receptors	Kainate receptor-glutamate complex	3
R-HSA-4551638	SUMOylation of chromatin organization proteins	R-HSA-4615872	RANBP2 SUMOylates HDAC4 with SUMO1	Nuclear Pore Complex (NPC)	3
R-HSA-4551638	SUMOylation of chromatin organization proteins	R-HSA-4615987	RANBP2 SUMOylates HDAC4 with SUMO2,3	Nuclear Pore Complex (NPC)	3
R-HSA-4570464	SUMOylation of RNA binding proteins	R-HSA-4570493	RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1	Nuclear Pore Complex (NPC)	3
R-HSA-4608870	Asymmetric localization of PCP proteins	R-HSA-4608852	SMURF1/2 ubiquitinates PRICKLE1	PARD6A:pp-DVL2:SMURF	1
R-HSA-4615885	SUMOylation of DNA replication proteins	R-HSA-4655355	RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)	RANBP2:RANGAP1-SUMO1:UBE2I:Nuclear Pore Complex (NPC)	3
R-HSA-4615885	SUMOylation of DNA replication proteins	R-HSA-5228525	RANBP2 SUMOylates TOP2A with SUMO1	Nuclear Pore Complex (NPC)	3
R-HSA-4641263	Regulation of FZD by ubiquitination	R-HSA-4641246	ZNRF3 autoubiquitinates to promote its internalization	RSPO:LGR:ZNRF3,RNF43	2
R-HSA-4641263	Regulation of FZD by ubiquitination	R-HSA-4641253	ZNRF3 ubiquitinates FZD to promote its downregulation	N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43	2
R-HSA-4655355	reaction:RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B): is xrefed to this process	R-HSA-4655355	RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)	RANBP2:RANGAP1-SUMO1:UBE2I:Nuclear Pore Complex (NPC)	3
R-HSA-5099900	WNT5A-dependent internalization of FZD4	R-HSA-5138432	DVL2 is phosphorylated by PKC	Activated Protein kinase C (alpha, beta, gamma isoforms)	2
R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-879909	Activation of STAT5a/b by JAK2	High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5	3
R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-914036	SHP1 and SHP2 dephosphorylate Y628 of IL3RB	High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2	3
R-HSA-5218920	VEGFR2 mediated vascular permeability	R-HSA-202127	NO biosynthesis	p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4	2
R-HSA-5218921	VEGFR2 mediated cell proliferation	R-HSA-169683	IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol	ITPR:I(1,4,5)P3 tetramer	2
R-HSA-5218921	VEGFR2 mediated cell proliferation	R-HSA-5218823	PKC phosphorylates sphingosine kinase 1	DAG:active PKC:Ca+2	2
R-HSA-5228525	reaction:RANBP2 SUMOylates TOP2A with SUMO1: is xrefed to this process	R-HSA-5228525	RANBP2 SUMOylates TOP2A with SUMO1	Nuclear Pore Complex (NPC)	3
R-HSA-5357956	TNFR1-induced NFkappaB signaling pathway	R-HSA-5357757	BIRC(cIAP1/2) ubiquitinates RIPK1	TNF-alpha:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3	3
R-HSA-5358346	Hedgehog ligand biogenesis	R-HSA-5362412	SYVN1 ubiquitinates Hh C-terminal fragments	C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer	4
R-HSA-5358346	Hedgehog ligand biogenesis	R-HSA-5362459	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol	ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer	4
R-HSA-5368286	Mitochondrial translation initiation	R-HSA-5389839	39S subunit binds 28S subunit:mRNA:fMet-tRNA	28S ribosomal subunit:MTIF3:MTIF2:GTP:mRNA:fMet-tRNA	2
R-HSA-5423646	Aflatoxin activation and detoxification	R-HSA-5433067	DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG	DPEP1,2,3 dimers	2
R-HSA-5576890	Phase 3 - rapid repolarisation	R-HSA-5577050	AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region	AKAP9:KCNQ1 tetramer:KCNE dimer	2
R-HSA-5576893	Phase 2 - plateau phase	R-HSA-5577050	AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region	AKAP9:KCNQ1 tetramer:KCNE dimer	2
R-HSA-5578749	Transcriptional regulation by small RNAs	R-HSA-5578744	Importin-8 imports AGO2:miRNA into the nucleus	Nuclear Pore Complex (NPC)	3
R-HSA-5578775	Ion homeostasis	R-HSA-169683	IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol	ITPR:I(1,4,5)P3 tetramer	2
R-HSA-5578775	Ion homeostasis	R-HSA-2855020	RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol	RYR tetramer:FKBP1B tetramer:CASQ polymer:TRDN:junctin	3
R-HSA-5578775	Ion homeostasis	R-HSA-434798	Calcium influx via CRAC	CRAC channel	2
R-HSA-5607763	CLEC7A (Dectin-1) induces NFAT activation	R-HSA-169683	IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol	ITPR:I(1,4,5)P3 tetramer	2
R-HSA-5607764	CLEC7A (Dectin-1) signaling	R-HSA-5607756	TRAF6 oligomer autoubiquitinates	p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers	2
R-HSA-5607764	CLEC7A (Dectin-1) signaling	R-HSA-5607757	K63polyUb-TRAF6 ubiquitinates TAK1	p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2	2
R-HSA-5621480	Dectin-2 family	R-HSA-5621370	SYK autophosphorylates	pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK	2
R-HSA-5625740	RHO GTPases activate PKNs	R-HSA-5623667	PDPK1 phosphorylates PKN1,2,3	RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3	2
R-HSA-5625900	RHO GTPases activate CIT	R-HSA-5671919	Activated CIT phosphorylates MRLCs	RHOA,RHOB,RHOC,RAC1:GTP:CIT	2
R-HSA-5627117	RHO GTPases Activate ROCKs	R-HSA-419083	Myosin phosphatase inactivation by ROCK	Activated ROCK:RhoA/B/C:GTP	2
R-HSA-5627117	RHO GTPases Activate ROCKs	R-HSA-419087	LIM kinase phosphorylation by ROCK	Activated ROCK:RhoA/B/C:GTP	2
R-HSA-5627117	RHO GTPases Activate ROCKs	R-HSA-419197	Myosin regulatory light chain phosphorylation by ROCK	Activated ROCK:RhoA/B/C:GTP	2
R-HSA-5627123	RHO GTPases activate PAKs	R-HSA-5627775	Autophosphorylation of PAK1,2,3	CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3	2
R-HSA-5632684	Hedgehog 'on' state	R-HSA-5632648	SMURF1/2 ubiquitinates PTCH1	PTCH1:SMURF	2
R-HSA-5654219	Phospholipase C-mediated cascade: FGFR1	R-HSA-5654149	Activated FGFR1 phosphorylates PLCG1	activated FGFR1:PLCG1	2
R-HSA-5654221	Phospholipase C-mediated cascade; FGFR2	R-HSA-5654147	Activated FGFR2 phosphorylates PLCG1	activated FGFR2:PLCG1	2
R-HSA-5654227	Phospholipase C-mediated cascade; FGFR3	R-HSA-5654222	Activated FGFR3 phosphorylates PLCG1	activated FGFR3:PLCG1	2
R-HSA-5654228	Phospholipase C-mediated cascade; FGFR4	R-HSA-5654151	Activated FGFR4 phosphorylates PLCG1	activated FGFR4:PLCG1	2
R-HSA-5654688	SHC-mediated cascade:FGFR1	R-HSA-5654582	Activated FGFR1 phosphorylates SHC1	Activated FGFR1:SHC1	3
R-HSA-5654688	SHC-mediated cascade:FGFR1	R-HSA-5654600	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Activated FGFR1:p-SHC1:GRB2:SOS1	3
R-HSA-5654689	PI-3K cascade:FGFR1	R-HSA-5654690	FGFR1-associated PI3K phosphorylates PIP2 to PIP3	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K	3
R-HSA-5654689	PI-3K cascade:FGFR1	R-HSA-5654692	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K	3
R-HSA-5654693	FRS-mediated FGFR1 signaling	R-HSA-5654392	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange	Activated FGFR1:p-FRS2:GRB2:SOS1	3
R-HSA-5654693	FRS-mediated FGFR1 signaling	R-HSA-5654575	Activated FGFR1 phosphorylates FRS2	Activated FGFR1:FRS2	2
R-HSA-5654693	FRS-mediated FGFR1 signaling	R-HSA-5654578	Activated FGFR1 phosphorylates FRS3	Activated FGFR1:FRS3	2
R-HSA-5654693	FRS-mediated FGFR1 signaling	R-HSA-5654587	Activated FGFR1:p-FRS phosphorylates PPTN11	Activated FGFR1:p-FRS:PTPN11	3
R-HSA-5654695	PI-3K cascade:FGFR2	R-HSA-5654697	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K	3
R-HSA-5654695	PI-3K cascade:FGFR2	R-HSA-5654701	FGFR2-associated PI3K phosphorylates PIP2 to PIP3	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K	3
R-HSA-5654699	SHC-mediated cascade:FGFR2	R-HSA-5654402	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Activated FGFR2:pY-SHC1:GRB2:SOS1	3
R-HSA-5654699	SHC-mediated cascade:FGFR2	R-HSA-5654407	Activated FGFR2 phosphorylates SHC1	Activated FGFR2:SHC1	3
R-HSA-5654700	FRS-mediated FGFR2 signaling	R-HSA-5654397	Activated FGFR2 phosphorylates FRS2	Activated FGFR2:FRS2	2
R-HSA-5654700	FRS-mediated FGFR2 signaling	R-HSA-5654605	Activated FGFR2 phosphorylates FRS3	Activated FGFR2:FRS3	2
R-HSA-5654700	FRS-mediated FGFR2 signaling	R-HSA-5654607	Activated FGFR2 phosphorylates PPTN11	Activated FGFR2:p-FRS:PTPN11	3
R-HSA-5654700	FRS-mediated FGFR2 signaling	R-HSA-5654618	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Activated FGFR2:p-FRS:GRB2:SOS1	3
R-HSA-5654704	SHC-mediated cascade:FGFR3	R-HSA-5654634	Activated FGFR3 phosphorylates SHC1	Activated FGFR3:SHC1	3
R-HSA-5654704	SHC-mediated cascade:FGFR3	R-HSA-5654647	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Activated FGFR3:pY-SHC1:GRB2:SOS1	3
R-HSA-5654706	FRS-mediated FGFR3 signaling	R-HSA-5654413	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Activated FGFR3:p-FRS:GRB2:SOS1	3
R-HSA-5654706	FRS-mediated FGFR3 signaling	R-HSA-5654628	Activated FGFR3 phosphorylates FRS3	Activated FGFR3:FRS3	2
R-HSA-5654706	FRS-mediated FGFR3 signaling	R-HSA-5654631	Activated FGFR3 phosphorylates PPTN11	Activated FGFR3:p-FRS:PTPN11	3
R-HSA-5654710	PI-3K cascade:FGFR3	R-HSA-5654705	FGFR3-associated PI3K phosphorylates PIP2 to PIP3	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K	3
R-HSA-5654710	PI-3K cascade:FGFR3	R-HSA-5654709	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K	3
R-HSA-5654712	FRS-mediated FGFR4 signaling	R-HSA-5654653	Activated FGFR4 phosphorylates FRS3	Activated FGFR4:FRS3	2
R-HSA-5654712	FRS-mediated FGFR4 signaling	R-HSA-5654655	Activated FGFR4 phosphorylates PPTN11	Activated FGFR4:p-FRS:PTPN11	3
R-HSA-5654712	FRS-mediated FGFR4 signaling	R-HSA-5654663	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Activated FGFR4:p-FRS2:GRB2:SOS1	3
R-HSA-5654719	SHC-mediated cascade:FGFR4	R-HSA-5654426	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Activated FGFR4:pY-SHC1:GRB2:SOS1	3
R-HSA-5654719	SHC-mediated cascade:FGFR4	R-HSA-5654428	Activated FGFR4 phosphorylates SHC1	Activated FGFR4:SHC1	3
R-HSA-5654720	PI-3K cascade:FGFR4	R-HSA-5654714	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K	3
R-HSA-5654720	PI-3K cascade:FGFR4	R-HSA-5654717	FGFR4-associated PI3K phosphorylates PIP2 to PIP3	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K	3
R-HSA-5654726	Negative regulation of FGFR1 signaling	R-HSA-5654672	CBL ubiquitinates FRS2 and FGFR1	Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2	3
R-HSA-5654727	Negative regulation of FGFR2 signaling	R-HSA-5654677	CBL ubiquitinates FRS2 and FGFR2	Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2	3
R-HSA-5654732	Negative regulation of FGFR3 signaling	R-HSA-5654679	CBL ubiquitinates FRS2 and FGFR3	Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2	3
R-HSA-5654733	Negative regulation of FGFR4 signaling	R-HSA-5654684	CBL ubiquitinates FRS2 and FGFR4	Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2	3
R-HSA-5658442	Regulation of RAS by GAPs	R-HSA-5658231	RAS GAPs stimulate RAS GTPase activity	p21 RAS:GTP:RAS GAPs	2
R-HSA-5663220	RHO GTPases Activate Formins	R-HSA-5665809	SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments	SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin	2
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	R-HSA-5668414	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK	Non-canonical NF-kB initiating TNFRSF memebers	3
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	R-HSA-5668454	K63polyUb-cIAP1,2 ubiquitinates TRAF3	TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK	3
R-HSA-5668599	RHO GTPases Activate NADPH Oxidases	R-HSA-5218841	NADPH oxidase 2 generates superoxide from oxygen	NOX2 complex:RAC1:GTP	2
R-HSA-5668599	RHO GTPases Activate NADPH Oxidases	R-HSA-5668629	Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP	NOX2 complex:RAC2:GTP	3
R-HSA-5668599	RHO GTPases Activate NADPH Oxidases	R-HSA-5668718	NOX1 complex:RAC1:GTP generates superoxide from oxygen	NOX1 complex:RAC1:GTP	2
R-HSA-5668599	RHO GTPases Activate NADPH Oxidases	R-HSA-5668731	NOX3 complex:RAC1:GTP generates superoxide from oxygen	NOX3 complex:RAC1:GTP	2
R-HSA-5672017	reaction:Rheb in the mTORC1 complex hydrolyses GTP: is xrefed to this process	R-HSA-5672017	Rheb in the mTORC1 complex hydrolyses GTP	mTORC1:Ragulator:Rag:GNP:RHEB:GTP	2
R-HSA-5674135	MAP2K and MAPK activation	R-HSA-5672973	MAP2Ks phosphorylate MAPKs	activated RAF:scaffold:p-2S MAP2K:MAPK complex	3
R-HSA-5674135	MAP2K and MAPK activation	R-HSA-5672978	RAF phosphorylates MAP2K dimer	activated RAF:scaffold:MAP2K:MAPK complex	3
R-HSA-5674135	MAP2K and MAPK activation	R-HSA-5674373	MAP2Ks phosphorylate MAPK at the Golgi membrane	IL17RD:p-2S MAP2Ks:MAPKs	2
R-HSA-5687128	MAPK6/MAPK4 signaling	R-HSA-5627775	Autophosphorylation of PAK1,2,3	CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3	2
R-HSA-5689880	Ub-specific processing proteases	R-HSA-5696968	USP20, USP33 deubiquitinate ADRB2	USP20,USP33:PolyUb-ADRB2	2
R-HSA-5689880	Ub-specific processing proteases	R-HSA-6782820	USP17 deubiquitinates SUDS3	USP17:K63polyUb-SUDS3	2
R-HSA-611105	Respiratory electron transport	R-HSA-163217	NADH enters the respiratory chain at Complex I	Complex I	2
R-HSA-629587	Highly sodium permeable acetylcholine nicotinic receptors	R-HSA-622325	Activation of highly sodium permeable nicotinic acetylcholine receptors	O-Acetylcholine bound to Acetylcholine receptor	2
R-HSA-629597	Highly calcium permeable nicotinic acetylcholine receptors	R-HSA-622326	Activation of highly calcium permeable nicotinic acetylcholine receptors	0-acteylcholine bound to calcium permeable nictonic acteylcholine receptor complex	2
R-HSA-6783483	reaction:tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol: is xrefed to this process	R-HSA-6783483	tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol	Nuclear Pore Complex (NPC)	3
R-HSA-6783783	Interleukin-10 signaling	R-HSA-6784006	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2	IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3	3
R-HSA-6783783	Interleukin-10 signaling	R-HSA-6784319	JAK1,TYK2 phosphorylate JAK1,TYK2	IL10 ligand/receptor complex	3
R-HSA-6783783	Interleukin-10 signaling	R-HSA-6784324	p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA	IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2	3
R-HSA-6784531	tRNA processing in the nucleus	R-HSA-6783483	tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol	Nuclear Pore Complex (NPC)	3
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	R-HSA-6788582	STAT1,STAT3,STAT6 phosphorylation	IL13:p-Y-IL13RA:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2:JAK1:STAT1,STAT6,STAT3	3
R-HSA-6803544	Ion influx/efflux at host-pathogen interface	R-HSA-6803545	ATP7A transports cytosolic Cu2+ to phagosomal lumen	ATP7A:PDZD11	2
R-HSA-6806942	MET Receptor Activation	R-HSA-6806974	MET dimers autophosphorylate	HGF:MET dimer	2
R-HSA-6807004	Negative regulation of MET activity	R-HSA-8875451	MET phosphorylates CBL	HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL)	3
R-HSA-6807878	COPI-mediated anterograde transport	R-HSA-6807877	ARFGAPs stimulate ARF GTPase activity	RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin	2
R-HSA-6807878	COPI-mediated anterograde transport	R-HSA-6809015	NSF ATPase activity dissociates cis-SNARE at cis-Golgi	cis-SNARE:3xSNAP:NSF hexamer	2
R-HSA-6809371	Formation of the cornified envelope	R-HSA-6810894	Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking	TGM1:Ca2+, TGM5:Ca2+	2
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811414	GBF1 stimulates nucleotide exchange on ARF	RAB1:GTP:GBF1:ARF:GDP	2
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811418	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane	RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo	2
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811422	NSF ATPase activity dissociates cis-SNARE at the ER	SEC22B:STX18:USE1:BNIP1L:3xSNAPs:NSF hexamer	2
R-HSA-6811438	Intra-Golgi traffic	R-HSA-8847638	ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane	STX5:PalmC-YKT6:BET1L:GOSR1:NSF hexamer:3xSNAPs	2
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network	R-HSA-6811429	RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange	RAB6:GDP:RIC1:RGP1	2
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network	R-HSA-6814678	ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN	STX10:STX16:VTI1A:VAMP3:NSF hexamer:SNAPs	2
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network	R-HSA-6814683	NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN	STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs	2
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network	R-HSA-8847534	RAB43 hydrolyses GTP	RAB43:GTP:USP6NL	2
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-2316434	PI3K phosphorylates PIP2 to PIP3	Activator:PI3K	3
R-HSA-74713	IRS activation	R-HSA-74711	Phosphorylation of IRS	IRS:Insulin:p-6Y-Insulin receptor	3
R-HSA-74751	Insulin receptor signalling cascade	R-HSA-74742	Phosphorylation of SHC1	Insulin:p-6Y-Insulin receptor:SHC1	3
R-HSA-74752	Signaling by Insulin receptor	R-HSA-74715	Autophosphorylation of insulin receptor	Insulin:Insulin receptor	2
R-HSA-75097	reaction:Transport of the export-competent mRNP complex through the NPC: is xrefed to this process	R-HSA-75097	Transport of the export-competent mRNP complex through the NPC	Nuclear Pore Complex (NPC)	3
R-HSA-77285	Beta oxidation of myristoyl-CoA to lauroyl-CoA	R-HSA-77271	3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA	Trifunctional Protein	1
R-HSA-77285	Beta oxidation of myristoyl-CoA to lauroyl-CoA	R-HSA-77277	trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA	Trifunctional Protein	1
R-HSA-77285	Beta oxidation of myristoyl-CoA to lauroyl-CoA	R-HSA-77283	(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H	Trifunctional Protein	1
R-HSA-77305	Beta oxidation of palmitoyl-CoA to myristoyl-CoA	R-HSA-77301	trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA	Trifunctional Protein	1
R-HSA-77305	Beta oxidation of palmitoyl-CoA to myristoyl-CoA	R-HSA-77303	(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H	Trifunctional Protein	1
R-HSA-77305	Beta oxidation of palmitoyl-CoA to myristoyl-CoA	R-HSA-77304	3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA	Trifunctional Protein	1
R-HSA-77310	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	R-HSA-77309	3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA	Trifunctional Protein	1
R-HSA-77346	Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	R-HSA-77340	3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA	Trifunctional Protein	1
R-HSA-77348	Beta oxidation of octanoyl-CoA to hexanoyl-CoA	R-HSA-77329	3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA	Trifunctional Protein	1
R-HSA-77350	Beta oxidation of hexanoyl-CoA to butanoyl-CoA	R-HSA-77321	3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA	Trifunctional Protein	1
R-HSA-77387	Insulin receptor recycling	R-HSA-74723	Endosome acidification	V-ATPase:ATP6AP1	2
R-HSA-83936	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-5672027	ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix	ARL2:GTP:ARL2BP:SLC25A4	2
R-HSA-8849175	Threonine catabolism	R-HSA-6798345	GCAT:PXLP dimer ligates CoASH to 2A-3OB to form Gly and Ac-CoA	GCAT:PXLP dimer:TDH tetramer	2
R-HSA-8849175	Threonine catabolism	R-HSA-6798667	TDH tetramer oxidises L-Thr to 2A-3OB	GCAT:PXLP dimer:TDH tetramer	2
R-HSA-8849471	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	R-HSA-8849082	ARHGAP35 stimulates RHOA GTPase activity	p-Y1105-ARHGAP35:RHOA:GTP	2
R-HSA-8851805	MET activates RAS signaling	R-HSA-8851827	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1	HGF:p-4Y-MET dimer:GRB2-1:SOS1	3
R-HSA-8851805	MET activates RAS signaling	R-HSA-8851877	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET	HGF:p-4Y-MET dimer:RANBP9:SOS1	3
R-HSA-8851805	MET activates RAS signaling	R-HSA-8851890	MET phosphorylates SHC1-2	HGF:p-4Y-MET dimer:SHC1-2	3
R-HSA-8851907	MET activates PI3K/AKT signaling	R-HSA-8851933	MET phosphorylates GAB1	HGF:p-4Y-MET dimer:GAB1,HGF:p-4Y-MET dimer:GRB2:GAB1	3
R-HSA-8851907	MET activates PI3K/AKT signaling	R-HSA-8852019	MET bound PI3K generates PIP3	HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K	3
R-HSA-8852405	Signaling by MST1	R-HSA-8852552	MST1R autophosphorylates	MST1 dimer:2xMST1R dimer	2
R-HSA-8854214	TBC/RABGAPs	R-HSA-8854329	TBC1D15 accelerates GTP hydrolysis by RAB7	RAB7:GTP	2
R-HSA-8854214	TBC/RABGAPs	R-HSA-8854612	TBC1D25 accelerates GTP hydrolysis by RAB33B	RAB33:GTP	2
R-HSA-8854691	Interleukin-20 family signaling	R-HSA-8982163	IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3	IL19:IL20RA:p-JAK1:IL20RB:STAT3	3
R-HSA-8854691	Interleukin-20 family signaling	R-HSA-8986985	STAT1 is phosphorylated after IL29-IL29 receptor interaction	IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1,STAT2, STAT3, STAT4, STAT5	3
R-HSA-8854691	Interleukin-20 family signaling	R-HSA-8986994	IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2	IL26:IL20RA:JAK1:IL10RB:TYK2	3
R-HSA-8854691	Interleukin-20 family signaling	R-HSA-8986995	IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA	IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2	3
R-HSA-8854691	Interleukin-20 family signaling	R-HSA-8987012	IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1	IL24:IL22RA1:JAK1:IL20RB	3
R-HSA-8854691	Interleukin-20 family signaling	R-HSA-8987040	IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1	IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2	3
R-HSA-8854691	Interleukin-20 family signaling	R-HSA-8987042	IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2	IL22:IL22RA1:JAK1:IL10RB:TYK2	3
R-HSA-8854691	Interleukin-20 family signaling	R-HSA-8987070	STAT3 is phosphorylated by the IL22 activated receptor complex	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3	3
R-HSA-8854691	Interleukin-20 family signaling	R-HSA-8987084	IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1	IL19:IL20RA:JAK1:IL20RB	3
R-HSA-8854691	Interleukin-20 family signaling	R-HSA-8987096	IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3	IL24:IL22RA1:p-JAK1:IL20RB:STAT3	3
R-HSA-8854691	Interleukin-20 family signaling	R-HSA-8987129	JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated	IL24:IL20RA:JAK1:IL20RB	3
R-HSA-8854691	Interleukin-20 family signaling	R-HSA-8987141	IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3	IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3:STAT3	3
R-HSA-8854691	Interleukin-20 family signaling	R-HSA-8987150	STAT3 is phosphorylated in IL24:IL24 receptor complex	IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3	3
R-HSA-8854691	Interleukin-20 family signaling	R-HSA-8987179	JAK2, JAK3 are phsophorylated after IL20 stimulus	IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3	3
R-HSA-8854691	Interleukin-20 family signaling	R-HSA-8987202	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2	IFNL1:IFNLR1:JAK1:IL10RB:TYK2	3
R-HSA-8854691	Interleukin-20 family signaling	R-HSA-8987255	STAT1 is phosphorylated after IL26:IL26Receptor interaction	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3	3
R-HSA-8856828	Clathrin-mediated endocytosis	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs	4
R-HSA-8856828	Clathrin-mediated endocytosis	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs	4
R-HSA-8857538	PTK6 promotes HIF1A stabilization	R-HSA-8857555	EGFR phosphorylates GPNMB	HBEGF:EGFR:GPNMB	2
R-HSA-8874081	MET activates PTK2 signaling	R-HSA-8874082	MET phosphorylates PTK2	HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC	3
R-HSA-8875555	MET activates RAP1 and RAC1	R-HSA-8875591	DOCK7 activates RAC1	HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7)	3
R-HSA-8875791	MET activates STAT3	R-HSA-8875817	MET phosphorylates STAT3	HGF:p-4Y-MET dimer:STAT3	3
R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs	R-HSA-8877451	MON1:CCZ1 exchanges GTP for GDP on RAB7	MON1:CCZ1	1
R-HSA-888590	GABA synthesis, release, reuptake and degradation	R-HSA-888589	Release of GABA at the synapse	Docked GABA loaded synaptic vesicle	4
R-HSA-888590	GABA synthesis, release, reuptake and degradation	R-HSA-917744	GABA loaded synaptic vesicle Docking and Priming	GABA Loaded synaptic vesicle	2
R-HSA-8940973	RUNX2 regulates osteoblast differentiation	R-HSA-8937844	SRC,YES1 phosphorylate YAP1	MyrG-p-Y419-SRC,MyrG-p-Y426-YES1:YAP1	2
R-HSA-8943724	Regulation of PTEN gene transcription	R-HSA-8944454	mTORC1 phosphorylates MAF1	mTORC1:Ragulator:Rag:GNP:RHEB:GTP	2
R-HSA-8963901	Chylomicron remodeling	R-HSA-174757	chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols	GPIHBP1:HSPG:LPL dimer	2
R-HSA-8983432	Interleukin-15 signaling	R-HSA-8983300	JAK3 is phosphorylated after IL15 stimulation	IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3	3
R-HSA-8983432	Interleukin-15 signaling	R-HSA-8983309	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:SHC1	3
R-HSA-8983432	Interleukin-15 signaling	R-HSA-8983371	STAT3 is phosphorylated after IL15-IL15 receptor interaction	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5)	3
R-HSA-8983432	Interleukin-15 signaling	R-HSA-8983424	GAB2 is activated	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2	3
R-HSA-8984722	Interleukin-35 Signalling	R-HSA-8950405	JAK2 and JAK1 activation after IL-35:IL35R interaction	IL35:IL6ST:JAK1:IL12RB2:JAK2	3
R-HSA-8984722	Interleukin-35 Signalling	R-HSA-8950453	JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4	IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4	3
R-HSA-9009391	Non-genomic estrogen signaling	R-HSA-202127	NO biosynthesis	p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4	2
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	R-HSA-9011300	ZSWIM8 ubiquitinates ROBO3.1	ROBO3.1:ZSWIM8-CUL2	2
R-HSA-9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9018572	EGFR phosphorylates NOTCH3	EGF:p-6Y-EGFR dimer:NICD3	3
R-HSA-9013973	TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013978	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex	activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7	3
R-HSA-9014325	TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9628444	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation	viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6	2
R-HSA-9018572	reaction:EGFR phosphorylates NOTCH3: is xrefed to this process	R-HSA-9018572	EGFR phosphorylates NOTCH3	EGF:p-6Y-EGFR dimer:NICD3	3
R-HSA-9020558	Interleukin-2 signaling	R-HSA-452097	Recruited STAT5 is phosphorylated	IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5	3
R-HSA-9020558	Interleukin-2 signaling	R-HSA-452122	JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB	IL2:IL2R trimer:p-JAK1:JAK3	3
R-HSA-9020591	Interleukin-12 signaling	R-HSA-8950354	STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction	IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4	3
R-HSA-9020591	Interleukin-12 signaling	R-HSA-8950423	JAK2 and TYK2 activation after IL12:IL12R interaction	IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2	3
R-HSA-9020591	Interleukin-12 signaling	R-HSA-8950757	IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated	IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2	3
R-HSA-9020702	Interleukin-1 signaling	R-HSA-446701	IRAK4-activated IRAK1 autophosphorylates	IL1 receptor complex- activated IRAK4:TOLLIP:p-IRAK1	3
R-HSA-9020933	Interleukin-23 signaling	R-HSA-8950269	STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor	IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4	3
R-HSA-9020933	Interleukin-23 signaling	R-HSA-8950364	IL23R in IL23:IL23 receptor complex is phosphorylated	IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2	3
R-HSA-9020933	Interleukin-23 signaling	R-HSA-8950591	JAK2 and TYK2 activation after IL23:IL23R interaction	IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2	3
R-HSA-9020956	Interleukin-27 signaling	R-HSA-8950340	IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation	IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2	3
R-HSA-9020956	Interleukin-27 signaling	R-HSA-8950485	STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction	IL27:EBI3:p-Y611-IL27RA:p-JAK1:p-Y-IL6ST:p-JAK1,p-JAK2,p-Y-TYK2:STAT1:STAT3	3
R-HSA-9020956	Interleukin-27 signaling	R-HSA-8950537	JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated	IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2)	3
R-HSA-9024909	BDNF activates NTRK2 (TRKB) signaling	R-HSA-9026464	BDNF-bound NTRK2 dimers trans-autophosphorylate	BDNF:NTRK2 homodimer	2
R-HSA-9025046	NTF3 activates NTRK2 (TRKB) signaling	R-HSA-9026502	NTF3-bound NTRK2 dimers trans-autophosphorylate	NTF3:NTRK2 homodimer	2
R-HSA-9026357	NTF4 activates NTRK2 (TRKB) signaling	R-HSA-9026510	NTF4-bound NTRK2 dimers trans-autophosphorylate	NTF4:NTRK2 homodimer	2
R-HSA-9026519	Activated NTRK2 signals through RAS	R-HSA-9026890	NTRK2 phosphorylates SHC1	BDNF,NTF4:p-5Y-NTRK2:SHC1-2,SHC1-3	3
R-HSA-9026527	Activated NTRK2 signals through PLCG1	R-HSA-9026579	NTRK2 phosphorylates PLCG1	BDNF,NTF4:p-5Y-NTRK2:PLCG1	2
R-HSA-9027276	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9021627	EPOR-associated PI3K phosphorylates PIP2 to PIP3	PI3K bound to EPOR	3
R-HSA-9027276	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027272	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2	EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2	3
R-HSA-9027277	Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9032478	EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate	EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-PLCG1,2	3
R-HSA-9027284	Erythropoietin activates RAS	R-HSA-9029158	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS	EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:SOS1,p-Y-VAV1	3
R-HSA-9028335	Activated NTRK2 signals through PI3K	R-HSA-9028519	NTRK2-activated PI3K generates PIP3	BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1	3
R-HSA-9028731	Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028728	NTRK2 phosphorylates FRS2	BDNF,NTF4:p-5Y-NTRK2:FRS2	3
R-HSA-9028731	Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9032426	NTRK2 phosphorylates FRS3	BDNF,NTF4:p-5Y-NTRK2:FRS3	2
R-HSA-9032845	Activated NTRK2 signals through CDK5	R-HSA-9032854	NTRK2 phosphorylates CDK5	BDNF:p-5Y-NTRK2 homodimer:CDK5:p35	3
R-HSA-9032845	Activated NTRK2 signals through CDK5	R-HSA-9032863	CDK5 phosphorylates NTRK2	BDNF:p-5Y-NTRK2 homodimer:p-Y15-CDK5:p35	3
R-HSA-9032845	Activated NTRK2 signals through CDK5	R-HSA-9033284	NTRK2 promotes TIAM1 phosphorylation	BDNF:p-5Y,S479-NTRK2 homodimer:TIAM1	3
R-HSA-9034013	NTF3 activates NTRK3 signaling	R-HSA-9034714	NTRK3 dimers trans-autophosphorylate	NTF3:NTRK3 homodimer	2
R-HSA-9034714	reaction:NTRK3 dimers trans-autophosphorylate: is xrefed to this process	R-HSA-9034714	NTRK3 dimers trans-autophosphorylate	NTF3:NTRK3 homodimer	2
R-HSA-9034793	Activated NTRK3 signals through PLCG1	R-HSA-9034814	NTRK3 phosphorylates PLCG1	NTF3:p-5Y-NTRK3 homodimer:PLCG1	2
R-HSA-9034864	Activated NTRK3 signals through RAS	R-HSA-9034875	NTRK3 phosphorylates SHC1	NTF3:p-5Y-NTRK3 homodimer:SHC1	3
R-HSA-917937	Iron uptake and transport	R-HSA-904830	Ferroportin mediates iron efflux on macrophages	SLC40A1:CP:6Cu2+	2
R-HSA-917977	Transferrin endocytosis and recycling	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	V-ATPase:ATP6AP1	2
R-HSA-918233	TRAF3-dependent IRF activation pathway	R-HSA-918229	Phosphorylation and release of IRF3/IRF7	dsRNA:RIG-1/MDA5:IPS-1:Ub-TRAF3:TBK1/IKKi:IRF3,IRF7	2
R-HSA-933541	TRAF6 mediated IRF7 activation	R-HSA-933525	Phosphorylation and release of IRF7	dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi:IRF7	2
R-HSA-933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933532	Processing of caspases	viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521)	2
R-HSA-936837	Ion transport by P-type ATPases	R-HSA-936802	ATP7A transports cytosolic Cu2+ to extracellular region	ATP7A:PDZD11	2
R-HSA-936964	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	R-HSA-166245	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex	activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7	3
R-HSA-937039	IRAK1 recruits IKK complex	R-HSA-937050	Pellino ubiquitinates hp-IRAK1	p-Pellino:hp-IRAK1:TRAF6	2
R-HSA-937072	TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-450358	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation	K63-linked polyUb TRAF6 complexes	3
R-HSA-9603381	Activated NTRK3 signals through PI3K	R-HSA-9603445	Activated NTRK3 stimulates PI3K activity	NTF3:p-5Y-NTRK3 homodimer:PI3K	3
R-HSA-9609736	Assembly and cell surface presentation of NMDA receptors	R-HSA-9610627	KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane	GRIN1:GRIN2B di-heterotetramer:LIN7:CASK:APBA1:DLG1:KIF17:Microtubule	2
R-HSA-9620244	Long-term potentiation	R-HSA-9618750	CaMKII phosphorylates AMPA receptor	Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+	3
R-HSA-975144	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975122	Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
p-Pellino:hp-IRAK1:TRAF6	2
R-HSA-975163	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-450358	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation	K63-linked polyUb TRAF6 complexes	3
R-HSA-975634	Retinoid metabolism and transport	R-HSA-2395768	LPL hydrolyses TGs from mature CMs	GPIHBP1:HSPG:LPL dimer	2
R-HSA-977443	GABA receptor activation	R-HSA-975340	GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol	GABR heteropentamers:GABA	3
R-HSA-977443	GABA receptor activation	R-HSA-975449	GABRR pentamer:GABA transports extracellular Cl- to cytosol	GABRR pentamer:GABA	2
R-HSA-977606	Regulation of Complement cascade	R-HSA-977371	Factor I inactivates Factor H-boundC3b	CFI:CFH,FHR3:C3b	2
R-HSA-977606	Regulation of Complement cascade	R-HSA-977615	Factor I inactivates MCP/CR1-bound C4b/C3b	CFI:CD46, CR1:C4b, C3b complexes	2
R-HSA-982772	Growth hormone receptor signaling	R-HSA-982807	JAK2 phosphorylation of GHR	Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer	3
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-1112666	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate	BLNK (SLP-65) Signalosome	2
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-1168376	STIM1 oligomerizes	ITPR:I(1,4,5)P3 tetramer	2
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-169683	IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol	ITPR:I(1,4,5)P3 tetramer	2
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-434798	Calcium influx via CRAC	CRAC channel	2
R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-1013012	Binding of Gbeta/gamma to GIRK/Kir3 channels	GABAB receptor:GABA	2
R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-1013013	Association of GABA B receptor with G protein beta-gamma subunits	GABAB receptor:GABA	2
R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-1013020	Activation of GIRK/Kir3 Channels	GABA B receptor G-protein beta-gamma and Kir3 channel complex	2